| # | Title | Journal | Year | Citations |
|---|
| 1 | Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection | Molecular Systems Biology | 2006 | 6,537 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells | Nature | 2013 | 3,901 |
| 4 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips | Nature Protocols | 2007 | 3,693 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models | Bioinformatics | 2003 | 2,811 |
| 7 | Fundamental analysis for visible-light communication system using LED lights | IEEE Transactions on Consumer Electronics | 2004 | 2,652 |
| 8 | Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota | Nature | 2013 | 2,339 |
| 9 | Direct observation of the rotation of F1-ATPase | Nature | 1997 | 2,244 |
| 10 | Cross-national prevalence and risk factors for suicidal ideation, plans and attempts | British Journal of Psychiatry | 2008 | 1,993 |
| 11 | TFOS DEWS II Definition and Classification Report | Ocular Surface | 2017 | 1,932 |
| 12 | Observation of the spin Seebeck effect | Nature | 2008 | 1,858 |
| 13 | TAK1 is a ubiquitin-dependent kinase of MKK and IKK | Nature | 2001 | 1,850 |
| 14 | MassBank: a public repository for sharing mass spectral data for life sciences | Journal of Mass Spectrometry | 2010 | 1,831 |
| 15 | Conversion of spin current into charge current at room temperature: Inverse spin-Hall effect | Applied Physics Letters | 2006 | 1,788 |
| 16 | A bacterium that degrades and assimilates poly(ethylene terephthalate) | Science | 2016 | 1,773 |
| 17 | Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche | Cell | 2004 | 1,753 |
| 18 | Motion control for advanced mechatronics | IEEE/ASME Transactions on Mechatronics | 1996 | 1,645 |
| 19 | Violent video game effects on aggression, empathy, and prosocial behavior in Eastern and Western countries: A meta-analytic review. | Psychological Bulletin | 2010 | 1,498 |
| 20 | A framework for quality management research and an associated measurement instrument | Journal of Operations Management | 1994 | 1,429 |
| 21 | Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein | Journal of Biological Chemistry | 2004 | 1,397 |
| 22 | Magnetic Vortex Core Observation in Circular Dots of Permalloy | Science | 2000 | 1,272 |
| 23 | Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys | Lancet, The | 2007 | 1,271 |
| 24 | Microglia-specific localisation of a novel calcium binding protein, Iba1 | Molecular Brain Research | 1998 | 1,228 |
| 25 | Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells | Nature Medicine | 2006 | 1,196 |
| 26 | One-Year Cardiovascular Event Rates in Outpatients With Atherothrombosis | JAMA - Journal of the American Medical Association | 2007 | 1,162 |
| 27 | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours | Journal of Pathology | 2014 | 1,151 |
| 28 | Constant Temperature Molecular Dynamics Methods | Progress of Theoretical Physics Supplement | 1991 | 1,144 |
| 29 | Traumatic spinal cord injury | Nature Reviews Disease Primers | 2017 | 1,138 |
| 30 | Gastroduodenal Disorders | Gastroenterology | 2016 | 1,088 |
| 31 | Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,081 |
| 32 | The performance of the Japanese version of the K6 and K10 in the World Mental Health Survey Japan | International Journal of Methods in Psychiatric Research | 2008 | 1,058 |
| 33 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth | Cancer Cell | 2011 | 1,020 |
| 34 | Cross-National Associations Between Gender and Mental Disorders in the World Health Organization World Mental Health Surveys | Archives of General Psychiatry | 2009 | 1,018 |
| 35 | Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes | Journal of Immunology | 2001 | 986 |
| 36 | The Impact of Quality Management Practices on Performance and Competitive Advantage | Decision Sciences | 1995 | 981 |
| 37 | Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 980 |
| 38 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014) | Hypertension Research | 2014 | 962 |
| 39 | Hallmarks of mechanochemistry: from nanoparticles to technology | Chemical Society Reviews | 2013 | 952 |
| 40 | Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration | Cancer | 2009 | 943 |
| 41 | Operative Results and Postoperative Progression of Ossification Among Patients With Ossification of Cervical Posterior Longitudinal Ligament | Spine | 1981 | 916 |
| 42 | Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry | Journal of Proteome Research | 2003 | 912 |
| 43 | Functional polymer microspheres | Progress in Polymer Science | 2000 | 887 |
| 44 | Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome | Nature Genetics | 1997 | 867 |
| 45 | Metabolic requirements for the maintenance of self-renewing stem cells | Nature Reviews Molecular Cell Biology | 2014 | 848 |
| 46 | The Systems Biology Graphical Notation | Nature Biotechnology | 2009 | 828 |
| 47 | Bladder cancer: Epidemiology, staging and grading, and diagnosis | Urology | 2005 | 825 |
| 48 | Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry | Cancer Research | 2009 | 822 |
| 49 | Variation in the safety of induced pluripotent stem cell lines | Nature Biotechnology | 2009 | 811 |
| 50 | Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase | Nature | 2001 | 810 |
