| # | Title | Journal | Year | Citations |
|---|
| 1 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 2 | A pathology atlas of the human cancer transcriptome | Science | 2017 | 2,570 |
| 3 | EAU Guidelines on Renal Cell Carcinoma: 2014 Update | European Urology | 2015 | 2,445 |
| 4 | Chronic inflammation in the etiology of disease across the life span | Nature Medicine | 2019 | 2,195 |
| 5 | EuroSCORE II | European Journal of Cardio-thoracic Surgery | 2012 | 2,159 |
| 6 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 7 | Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial | Lancet, The | 2010 | 1,584 |
| 8 | Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial | Lancet, The | 2017 | 1,475 |
| 9 | Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables | Lancet Diabetes and Endocrinology,the | 2018 | 1,430 |
| 10 | Temporal development of the gut microbiome in early childhood from the TEDDY study | Nature | 2018 | 1,220 |
| 11 | Tertiary lymphoid structures improve immunotherapy and survival in melanoma | Nature | 2020 | 1,209 |
| 12 | European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update | European Urology | 2019 | 1,022 |
| 13 | European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice | Contact Dermatitis | 2015 | 1,012 |
| 14 | Dynamics of Cell Generation and Turnover in the Human Heart | Cell | 2015 | 923 |
| 15 | Type 1 diabetes mellitus | Nature Reviews Disease Primers | 2017 | 790 |
| 16 | EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries | European Journal of Preventive Cardiology | 2016 | 772 |
| 17 | Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors | Mucosal Immunology | 2013 | 749 |
| 18 | Economic Burden of Obesity: A Systematic Literature Review | International Journal of Environmental Research and Public Health | 2017 | 744 |
| 19 | A Consensus Molecular Classification of Muscle-invasive Bladder Cancer | European Urology | 2020 | 741 |
| 20 | Neuron-specific enolase correlates with other prognostic markers after cardiac arrest | Neurology | 2011 | 730 |
| 21 | European Association of Urology Guidelines on Male Infertility: The 2012 Update | European Urology | 2012 | 730 |
| 22 | Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association | Diabetes Care | 2015 | 690 |
| 23 | 2018 Update of the EULAR recommendations for the management of large vessel vasculitis | Annals of the Rheumatic Diseases | 2020 | 667 |
| 24 | World Stroke Organization (WSO): Global Stroke Fact Sheet 2022 | International Journal of Stroke | 2022 | 649 |
| 25 | Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia | Nature Medicine | 2020 | 643 |
| 26 | European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage | International Journal of Stroke | 2014 | 638 |
| 27 | Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics | Modern Pathology | 2014 | 585 |
| 28 | Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials | Lancet, The | 2015 | 564 |
| 29 | Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia | Archives of General Psychiatry | 2012 | 554 |
| 30 | Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services | British Journal of Surgery | 2020 | 554 |
| 31 | Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study | Lancet Neurology, The | 2014 | 547 |
| 32 | Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial | Lancet, The | 2019 | 542 |
| 33 | Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 | Journal of Biological Chemistry | 2013 | 532 |
| 34 | The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients | BMC Cancer | 2012 | 531 |
| 35 | Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections | JAMA - Journal of the American Medical Association | 2017 | 520 |
| 36 | IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation | Immunity | 2013 | 514 |
| 37 | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 512 |
| 38 | Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper# | Intensive Care Medicine | 2020 | 504 |
| 39 | Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group | Ultrasound in Obstetrics and Gynecology | 2016 | 503 |
| 40 | Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing | Nature Communications | 2018 | 496 |
| 41 | Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 485 |
| 42 | Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group | Ultrasound in Obstetrics and Gynecology | 2015 | 461 |
| 43 | Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis | Diabetes | 2017 | 454 |
| 44 | Active Surveillance for Low-Risk Prostate Cancer Worldwide: The PRIAS Study | European Urology | 2013 | 450 |
| 45 | European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care | Intensive Care Medicine | 2021 | 450 |
| 46 | Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors | Nature Reviews Cardiology | 2018 | 449 |
| 47 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 48 | European Society for Swallowing Disorders – European Union Geriatric Medicine Society white paper: oropharyngeal dysphagia as a geriatric syndrome | Clinical Interventions in Aging | 2016 | 445 |
| 49 | Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial | Lancet Oncology, The | 2018 | 444 |
| 50 | Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease | Journal of Immunology | 2012 | 425 |
