# | Title | Journal | Year | Citations |
---|
1 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
2 | Antioxidant properties of phenolic compounds | Trends in Plant Science | 1997 | 3,320 |
3 | Congenital leptin deficiency is associated with severe early-onset obesity in humans | Nature | 1997 | 2,664 |
4 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
5 | GENCODE reference annotation for the human and mouse genomes | Nucleic Acids Research | 2019 | 2,350 |
6 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
7 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
8 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
9 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
10 | JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis | New England Journal of Medicine | 2012 | 1,543 |
11 | Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution | Intensive Care Medicine | 2000 | 1,511 |
12 | Design and Evaluation of Useful Bacterium-Specific PCR Primers That Amplify Genes Coding for Bacterial 16S rRNA | Applied and Environmental Microbiology | 1998 | 1,498 |
13 | Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial | Lancet, The | 2017 | 1,475 |
14 | Guillain-Barré syndrome | Lancet, The | 2005 | 1,392 |
15 | Medical image registration | Physics in Medicine and Biology | 2001 | 1,348 |
16 | Peptide Antibiotics | Antimicrobial Agents and Chemotherapy | 1999 | 1,227 |
17 | Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo | Cell | 1997 | 1,224 |
18 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
19 | NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X | Diabetologia | 1997 | 1,108 |
20 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
21 | Patterning the Vertebrate Neuraxis | Science | 1996 | 1,091 |
22 | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility | Nature Genetics | 2007 | 1,063 |
23 | Difficult Airway Society guidelines for management of the unanticipated difficult intubation | Anaesthesia | 2004 | 1,000 |
24 | Mortality and causes of death in the WHO multinational study of vascular disease in diabetes | Diabetologia | 2001 | 979 |
25 | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease | Nature Genetics | 2017 | 943 |
26 | Regulation of Cutaneous Malignancy by γδ T Cells | Science | 2001 | 895 |
27 | Is Type II diabetes mellitus a disease of the innate immune system? | Diabetologia | 1998 | 892 |
28 | Multiple common variants for celiac disease influencing immune gene expression | Nature Genetics | 2010 | 871 |
29 | CONTROLLED TRIAL OF PREDNISOLONE IN ACUTE POLYNEUROPATHY | Lancet, The | 1978 | 865 |
30 | Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation | Journal of Neuroscience | 1999 | 864 |
31 | IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours | Journal of Pathology | 2011 | 834 |
32 | Segmental patterns of neuronal development in the chick hindbrain | Nature | 1989 | 829 |
33 | Autoantibodies against the High-Affinity IgE Receptor as a Cause of Histamine Release in Chronic Urticaria | New England Journal of Medicine | 1993 | 812 |
34 | Microalbuminuria Reduction With Valsartan in Patients With Type 2 Diabetes Mellitus | Circulation | 2002 | 812 |
35 | Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study | Lancet, The | 2011 | 803 |
36 | Electrophysiological classification of guillain‐barré syndrome: Clinical associations and outcome | Annals of Neurology | 1998 | 778 |
37 | Guidelines for the diagnosis and management of individuals with neurofibromatosis 1 | Journal of Medical Genetics | 2006 | 778 |
38 | Mental health of hospital consultants: the effects of stress and satisfaction at work | Lancet, The | 1996 | 760 |
39 | Campylobacter jejuniInfection and Guillain–Barré Syndrome | New England Journal of Medicine | 1995 | 743 |
40 | Triple negative tumours: a critical review | Histopathology | 2008 | 734 |
41 | The STROCSS statement: Strengthening the Reporting of Cohort Studies in Surgery | International Journal of Surgery | 2017 | 727 |
42 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
43 | Natural selection on EPAS1 ( HIF2α ) associated with low hemoglobin concentration in Tibetan highlanders | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 708 |
44 | A common molecular basis for three inherited kidney stone diseases | Nature | 1996 | 694 |
45 | Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy") | Lancet, The | 1992 | 691 |
46 | A Screening Instrument for Autism at 18 Months of Age: A 6-Year Follow-up Study | Journal of the American Academy of Child and Adolescent Psychiatry | 2000 | 674 |
47 | Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions | Nature | 1990 | 669 |
48 | CORONARY-HEART-DISEASE RISK AND IMPAIRED GLUCOSE TOLERANCE The Whitehall Study | Lancet, The | 1980 | 665 |
49 | Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial | Nature Medicine | 2018 | 649 |
50 | Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution | Journal of Pathology | 1985 | 647 |