| # | Title | Journal | Year | Citations |
|---|
| 1 | Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure | Hypertension | 2003 | 11,852 |
| 2 | Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis | Chest | 1992 | 9,341 |
| 3 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 4 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
| 5 | Microbial translocation is a cause of systemic immune activation in chronic HIV infection | Nature Medicine | 2006 | 3,107 |
| 6 | Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer | New England Journal of Medicine | 2007 | 2,865 |
| 7 | Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events | New England Journal of Medicine | 2006 | 2,582 |
| 8 | Conservation of Resources in the Organizational Context: The Reality of Resources and Their Consequences | Annual Review of Organizational Psychology and Organizational Behavior | 2018 | 2,238 |
| 9 | Estrogen plus Progestin and the Risk of Coronary Heart Disease | New England Journal of Medicine | 2003 | 1,928 |
| 10 | The Sentinel Node in Breast Cancer — A Multicenter Validation Study | New England Journal of Medicine | 1998 | 1,907 |
| 11 | Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment | New England Journal of Medicine | 2005 | 1,709 |
| 12 | Clinical practice guidelines for antimicrobial prophylaxis in surgery | American Journal of Health-System Pharmacy | 2013 | 1,643 |
| 13 | Effects of Treating Depression and Low Perceived Social Support on Clinical Events After Myocardial Infarction | JAMA - Journal of the American Medical Association | 2003 | 1,579 |
| 14 | New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society | Clinical Orthopaedics and Related Research | 2011 | 1,516 |
| 15 | Guidelines for the Evaluation and Management of Status Epilepticus | Neurocritical Care | 2012 | 1,296 |
| 16 | Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement | Thyroid | 2014 | 1,283 |
| 17 | The classification of glomerulonephritis in systemic lupus erythematosus revisited | Kidney International | 2004 | 1,272 |
| 18 | A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers | Neurology | 2016 | 1,216 |
| 19 | A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression | New England Journal of Medicine | 2000 | 1,188 |
| 20 | Fibromyalgia Criteria and Severity Scales for Clinical and Epidemiological Studies: A Modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia | Journal of Rheumatology | 2011 | 1,162 |
| 21 | A Calcium Antagonist vs a Non–Calcium Antagonist Hypertension Treatment Strategy for Patients With Coronary Artery Disease | JAMA - Journal of the American Medical Association | 2003 | 1,107 |
| 22 | Vagus nerve stimulation therapy for partial-onset seizures | Neurology | 1998 | 1,070 |
| 23 | Effect of Estrogen Plus Progestin on Stroke in Postmenopausal Women | JAMA - Journal of the American Medical Association | 2003 | 1,021 |
| 24 | Effects of Coenzyme Q10 in Early Parkinson Disease | Archives of Neurology | 2002 | 994 |
| 25 | Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Acta Neuropathologica | 2007 | 978 |
| 26 | Scoliosis Research Society—Schwab Adult Spinal Deformity Classification | Spine | 2012 | 976 |
| 27 | Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 967 |
| 28 | Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation | New England Journal of Medicine | 2015 | 951 |
| 29 | Pipeline for Uncoilable or Failed Aneurysms: Results from a Multicenter Clinical Trial | Radiology | 2013 | 937 |
| 30 | Mood Disorders in the Medically Ill: Scientific Review and Recommendations | Biological Psychiatry | 2005 | 913 |
| 31 | Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome | Pain | 2010 | 911 |
| 32 | Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer | New England Journal of Medicine | 2006 | 907 |
| 33 | Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease | Annals of Internal Medicine | 2000 | 905 |
| 34 | Critical Care Management of Patients Following Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference | Neurocritical Care | 2011 | 886 |
| 35 | Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscle | Nature | 1987 | 864 |
| 36 | Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline | Annals of Thoracic Surgery | 2007 | 860 |
| 37 | Mild Cognitive Impairment Can Be Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials | Archives of Neurology | 2004 | 853 |
| 38 | gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma | New England Journal of Medicine | 2011 | 809 |
| 39 | Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci | Nature Genetics | 2009 | 729 |
| 40 | Consensus Auditory-Perceptual Evaluation of Voice: Development of a Standardized Clinical Protocol | American Journal of Speech-Language Pathology | 2009 | 724 |
| 41 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 719 |
| 42 | Longitudinal Analysis of the Association Between Vasomotor Symptoms and Race/Ethnicity Across the Menopausal Transition: Study of Women’s Health Across the Nation | American Journal of Public Health | 2006 | 699 |
| 43 | Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer | JAMA - Journal of the American Medical Association | 2006 | 696 |
| 44 | Intrathecal Baclofen for Severe Spinal Spasticity | New England Journal of Medicine | 1989 | 695 |
| 45 | Population based study of social and productive activities as predictors of survival among elderly Americans | BMJ: British Medical Journal | 1999 | 695 |
| 46 | Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: Preliminary Results of a Phase III Trial in Regionally Advanced, Unresectable Non-Small-Cell Lung Cancer | Journal of the National Cancer Institute | 1995 | 693 |
| 47 | Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension | JAMA - Journal of the American Medical Association | 1996 | 687 |
| 48 | Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia | Blood | 2010 | 687 |
| 49 | Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats | Nature Medicine | 2016 | 666 |
| 50 | Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome | JAMA - Journal of the American Medical Association | 1995 | 643 |
