| # | Title | Journal | Year | Citations |
|---|
| 1 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells | Nature | 1988 | 10,647 |
| 2 | Magnetic control of ferroelectric polarization | Nature | 2003 | 4,204 |
| 3 | Edge state in graphene ribbons: Nanometer size effect and edge shape dependence | Physical Review B | 1996 | 3,851 |
| 4 | Statistical inference in vector autoregressions with possibly integrated processes | Journal of Econometrics | 1995 | 3,788 |
| 5 | The complete genome sequence of the Gram-positive bacterium Bacillus subtilis | Nature | 1997 | 3,519 |
| 6 | An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements | Biochemical and Biophysical Research Communications | 1997 | 3,495 |
| 7 | Active sites of nitrogen-doped carbon materials for oxygen reduction reaction clarified using model catalysts | Science | 2016 | 3,435 |
| 8 | The 2015 World Health Organization Classification of Lung Tumors | Journal of Thoracic Oncology | 2015 | 3,313 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 10 | Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Genes and Development | 1999 | 3,000 |
| 11 | Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment | Journal of the American Medical Directors Association | 2020 | 2,796 |
| 12 | Peculiar Localized State at Zigzag Graphite Edge | Journal of the Physical Society of Japan | 1996 | 2,569 |
| 13 | Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor | Nature | 1990 | 2,443 |
| 14 | The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 2,402 |
| 15 | Angiotensin-converting enzyme 2 protects from severe acute lung failure | Nature | 2005 | 2,264 |
| 16 | Exchange Monte Carlo Method and Application to Spin Glass Simulations | Journal of the Physical Society of Japan | 1996 | 2,213 |
| 17 | The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype | Nature Medicine | 2001 | 2,145 |
| 18 | Phylogenomics resolves the timing and pattern of insect evolution | Science | 2014 | 2,096 |
| 19 | Repeated temperature modulation epitaxy for p-type doping and light-emitting diode based on ZnO | Nature Materials | 2004 | 1,963 |
| 20 | Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell | Science | 1996 | 1,926 |
| 21 | Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice | Cell | 2007 | 1,925 |
| 22 | Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 | Molecular and Cellular Biology | 2004 | 1,878 |
| 23 | Whole genome sequencing of meticillin-resistant Staphylococcus aureus | Lancet, The | 2001 | 1,835 |
| 24 | Frequent pathway mutations of splicing machinery in myelodysplasia | Nature | 2011 | 1,764 |
| 25 | Phenomenological theory of unconventional superconductivity | Reviews of Modern Physics | 1991 | 1,719 |
| 26 | Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 1,719 |
| 27 | Mortality risk attributable to high and low ambient temperature: a multicountry observational study | Lancet, The | 2015 | 1,676 |
| 28 | Further analysis of the data by Akaike's information criterion and the finite corrections | Communications in Statistics - Theory and Methods | 1978 | 1,635 |
| 29 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,634 |
| 30 | Ultralong spin coherence time in isotopically engineered diamond | Nature Materials | 2009 | 1,596 |
| 31 | Nrf2–Keap1 defines a physiologically important stress response mechanism | Trends in Molecular Medicine | 2004 | 1,529 |
| 32 | Breast Disease: Clinical Application of US Elastography for Diagnosis | Radiology | 2006 | 1,454 |
| 33 | JNdi-1: a neodymium isotopic reference in consistency with LaJolla neodymium | Chemical Geology | 2000 | 1,418 |
| 34 | QCD phenomenology based on a chiral effective Lagrangian | Physics Reports | 1994 | 1,407 |
| 35 | APHRODITE: Constructing a Long-Term Daily Gridded Precipitation Dataset for Asia Based on a Dense Network of Rain Gauges | Bulletin of the American Meteorological Society | 2012 | 1,395 |
| 36 | Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity | Neuron | 2001 | 1,307 |
| 37 | Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages | Journal of Biological Chemistry | 2000 | 1,297 |
| 38 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 1,294 |
| 39 | Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor | Nature | 2001 | 1,292 |
| 40 | Spectroscopic evidence for a pseudogap in the normal state of underdoped high-Tc superconductors | Nature | 1996 | 1,273 |
| 41 | The classification of glomerulonephritis in systemic lupus erythematosus revisited | Kidney International | 2004 | 1,272 |
| 42 | ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis | Science | 2008 | 1,224 |
| 43 | Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease | Nature Genetics | 2009 | 1,217 |
| 44 | Genome-wide analysis of mammalian promoter architecture and evolution | Nature Genetics | 2006 | 1,201 |
| 45 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 46 | The genome of the social amoeba Dictyostelium discoideum | Nature | 2005 | 1,179 |
| 47 | Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions | Nature Medicine | 2007 | 1,177 |
| 48 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2020 | 1,123 |
| 49 | Inferior epigastric artery skin flaps without rectus abdominis muscle | Journal of Plastic, Reconstructive and Aesthetic Surgery | 1989 | 1,080 |
| 50 | Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning | Nature Genetics | 1997 | 1,065 |
