| # | Title | Journal | Year | Citations |
|---|
| 1 | Hepatitis B e Antigen and the Risk of Hepatocellular Carcinoma | New England Journal of Medicine | 2002 | 1,170 |
| 2 | The signaling mechanism of ROS in tumor progression | Cancer and Metastasis Reviews | 2007 | 642 |
| 3 | Mesenchymal Stem Cells | Cell Transplantation | 2011 | 589 |
| 4 | High Levels of Hepatitis B Surface Antigen Increase Risk of Hepatocellular Carcinoma in Patients With Low HBV Load | Gastroenterology | 2012 | 469 |
| 5 | Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy | Cell Transplantation | 2015 | 410 |
| 6 | CELLO2GO: A Web Server for Protein subCELlular LOcalization Prediction with Functional Gene Ontology Annotation | PLoS ONE | 2014 | 357 |
| 7 | Functional Recovery of Stroke Rats Induced by Granulocyte Colony-Stimulating Factor–Stimulated Stem Cells | Circulation | 2004 | 335 |
| 8 | Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer | Biochemical and Biophysical Research Communications | 2008 | 318 |
| 9 | Effect of aging on gender differences in neural control of heart rate | American Journal of Physiology - Heart and Circulatory Physiology | 1999 | 315 |
| 10 | Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles | Bioorganic and Medicinal Chemistry | 2006 | 307 |
| 11 | Biocompatible and detectable carboxylated nanodiamond on human cell | Nanotechnology | 2007 | 250 |
| 12 | The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell–Cell Signaling to Virulence Gene Expression in Xanthomonas campestris | Journal of Molecular Biology | 2010 | 191 |
| 13 | Chronic daily headache in adolescents: Prevalence, impact, and medication overuse | Neurology | 2006 | 188 |
| 14 | Identification of novel DNA methylation markers in cervical cancer | International Journal of Cancer | 2008 | 188 |
| 15 | Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial | Cmaj | 2006 | 184 |
| 16 | Oncogenic role of DDX3 in breast cancer biogenesis | Oncogene | 2008 | 184 |
| 17 | Regulatory mechanisms controlling human E-cadherin gene expression | Oncogene | 2005 | 174 |
| 18 | Increased Risk of Dementia in Patients with Mild Traumatic Brain Injury: A Nationwide Cohort Study | PLoS ONE | 2013 | 171 |
| 19 | Functional gold nanoparticles as photothermal agents for selective-killing of pathogenic bacteria | Nanomedicine | 2007 | 170 |
| 20 | Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer | Frontiers in Endocrinology | 2020 | 168 |
| 21 | Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome | BJU International | 2009 | 166 |
| 22 | Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA | Clinical Cancer Research | 2007 | 164 |
| 23 | Antibacterial activity of Acinetobacter baumannii phage ϕAB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria | Applied Microbiology and Biotechnology | 2011 | 162 |
| 24 | Bactericidal Effects and Mechanisms of Visible Light-Responsive Titanium Dioxide Photocatalysts on Pathogenic Bacteria | Archivum Immunologiae Et Therapiae Experimentalis | 2012 | 160 |
| 25 | Survivin and p53 Modulate Quercetin-induced Cell Growth Inhibition and Apoptosis in Human Lung Carcinoma Cells | Journal of Biological Chemistry | 2004 | 156 |
| 26 | Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study | British Journal of Psychiatry | 2012 | 156 |
| 27 | Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species | Cancer and Metastasis Reviews | 2008 | 150 |
| 28 | The location and translocation of ndh genes of chloroplast origin in the Orchidaceae family | Scientific Reports | 2015 | 143 |
| 29 | Comparison of Capture Immunoglobulin M (IgM) and IgG Enzyme-Linked Immunosorbent Assay (ELISA) and Nonstructural Protein NS1 Serotype-Specific IgG ELISA for Differentiation of Primary and Secondary Dengue Virus Infections | Vaccine Journal | 2003 | 141 |
| 30 | The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy | Oxidative Medicine and Cellular Longevity | 2018 | 137 |
| 31 | Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan | Cancer Causes and Control | 2003 | 136 |
| 32 | Comparison of Effectiveness of Detrusor, Suburothelial and Bladder Base Injections of Botulinum Toxin A for Idiopathic Detrusor Overactivity | Journal of Urology | 2007 | 136 |
| 33 | Neurotrophic and Cytoprotective Action of Luteolin in PC12 Cells through ERK-Dependent Induction of Nrf2-Driven HO-1 Expression | Journal of Agricultural and Food Chemistry | 2010 | 136 |
| 34 | Using Biofunctionalized Nanoparticles To Probe Pathogenic Bacteria | Analytical Chemistry | 2004 | 133 |
| 35 | Effect of Interleukin-1 on Traumatic Brain Injury–Induced Damage to Hippocampal Neurons | Journal of Neurotrauma | 2005 | 132 |
| 36 | Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan | International Journal of Molecular Sciences | 2014 | 132 |
| 37 | Nitrilotriacetic Acid-Coated Magnetic Nanoparticles as Affinity Probes for Enrichment of Histidine-Tagged Proteins and Phosphorylated Peptides | Analytical Chemistry | 2007 | 130 |
| 38 | A New and Facile Method To Prepare Uniform Hollow MnO/Functionalized mSiO2 Core/Shell Nanocomposites | ACS Nano | 2011 | 130 |
| 39 | Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load | Hepatology | 2012 | 130 |
| 40 | Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT | Molecular Cancer Therapeutics | 2007 | 129 |
| 41 | Chromobacterium violaceum infection: A clinical review of an important but neglected infection | Journal of the Chinese Medical Association | 2011 | 128 |
| 42 | Hepatitis C virus: Virology, diagnosis and treatment | World Journal of Hepatology | 2015 | 127 |
| 43 | Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease | Journal of the American Heart Association | 2017 | 127 |
| 44 | Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke | Journal of Clinical Investigation | 2008 | 127 |
| 45 | Clinical guidelines for interstitial cystitis/bladder pain syndrome | International Journal of Urology | 2020 | 122 |
| 46 | Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats | Journal of Applied Physiology | 2006 | 121 |
| 47 | Arsenic exposure, urinary arsenic speciation, and the incidence of urothelial carcinoma: a twelve-year follow-up study | Cancer Causes and Control | 2008 | 120 |
| 48 | Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia | Marine Drugs | 2015 | 120 |
| 49 | Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis | Nutrients | 2017 | 120 |
| 50 | Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells | Oncotarget | 2015 | 120 |
