| Membrane transporters in drug development | Nature Reviews Drug Discovery | 2010 | 2.5K |
| Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials | Lancet, The | 2014 | 1.4K |
| Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial | Lancet Oncology, The | 2014 | 1.4K |
| Concordance of the toxicity of pharmaceuticals in humans and in animals | Regulatory Toxicology and Pharmacology | 2000 | 1.3K |
| Idarucizumab for Dabigatran Reversal | New England Journal of Medicine | 2015 | 1.2K |
| Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity | Thrombosis and Haemostasis | 2010 | 1.2K |
| Sexual problems and distress in United States women: prevalence and correlates | Obstetrics and Gynecology | 2008 | 927 |
| Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis | JAMA - Journal of the American Medical Association | 2015 | 842 |
| Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus | Circulation | 2014 | 834 |
| Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma | Science | 1990 | 826 |
| Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation | New England Journal of Medicine | 2017 | 804 |
| Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial | Journal of Thrombosis and Haemostasis | 2007 | 799 |
| An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus | Nature | 2003 | 777 |
| Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment | Cell | 2018 | 754 |
| A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease | European Respiratory Journal | 2002 | 722 |
| Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site | Nature Structural Biology | 2002 | 715 |
| Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor | Science | 1990 | 710 |
| Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial | Lancet Oncology, The | 2016 | 691 |
| Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis | Circulation | 2014 | 678 |
| Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase | Molecular Cell | 2007 | 671 |
| Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial | Lancet Oncology, The | 2014 | 639 |
| Idarucizumab for Dabigatran Reversal - Full Cohort Analysis | New England Journal of Medicine | 2017 | 639 |
| The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy) | Journal of the American College of Cardiology | 2014 | 585 |
| High-Turnover Palladium Catalysts in Cross-Coupling and Heck Chemistry: A Critical Overview | Advanced Synthesis and Catalysis | 2004 | 568 |
| Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium | European Respiratory Journal | 2002 | 567 |
