| # | Title | Journal | Year | Citations |
|---|
| 1 | Improved Survival with Ipilimumab in Patients with Metastatic Melanoma | New England Journal of Medicine | 2010 | 13,065 |
| 2 | The biofilm matrix | Nature Reviews Microbiology | 2010 | 7,296 |
| 3 | Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 7,261 |
| 4 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 5 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma | New England Journal of Medicine | 2015 | 6,773 |
| 6 | Involvement of chemokine receptors in breast cancer metastasis | Nature | 2001 | 4,837 |
| 7 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 8 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 9 | Biofilms: an emergent form of bacterial life | Nature Reviews Microbiology | 2016 | 3,725 |
| 10 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,697 |
| 11 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 12 | Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade | Science | 2016 | 2,445 |
| 13 | Genomic correlates of response to CTLA-4 blockade in metastatic melanoma | Science | 2015 | 2,275 |
| 14 | Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib | New England Journal of Medicine | 2015 | 2,240 |
| 15 | Present and Future of Surface-Enhanced Raman Scattering | ACS Nano | 2020 | 2,153 |
| 16 | Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial | Lancet, The | 2004 | 2,110 |
| 17 | Snakemake—a scalable bioinformatics workflow engine | Bioinformatics | 2012 | 2,041 |
| 18 | Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial | Lancet, The | 2010 | 2,002 |
| 19 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 20 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial | Lancet Oncology, The | 2014 | 1,932 |
| 21 | Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications | Angewandte Chemie - International Edition | 2014 | 1,894 |
| 22 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 23 | A Phase 3 Trial of Bevacizumab in Ovarian Cancer | New England Journal of Medicine | 2011 | 1,843 |
| 24 | Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal | Angewandte Chemie - International Edition | 2013 | 1,839 |
| 25 | Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology | Nature Nanotechnology | 2013 | 1,817 |
| 26 | Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline | Journal of Clinical Endocrinology and Metabolism | 2006 | 1,811 |
| 27 | Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma | Journal of Clinical Oncology | 2015 | 1,809 |
| 28 | Inverse magnetocaloric effect in ferromagnetic Ni–Mn–Sn alloys | Nature Materials | 2005 | 1,757 |
| 29 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 30 | The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report | Fertility and Sterility | 2009 | 1,639 |
| 31 | 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management | Journal of Crohn's and Colitis | 2017 | 1,547 |
| 32 | Nonlinear dynamics and breakup of free-surface flows | Reviews of Modern Physics | 1997 | 1,543 |
| 33 | Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial | Lancet, The | 2019 | 1,494 |
| 34 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 35 | The EPS Matrix: The “House of Biofilm Cells” | Journal of Bacteriology | 2007 | 1,379 |
| 36 | Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials | Lancet Oncology, The | 2015 | 1,369 |
| 37 | Ceritinib inALK-Rearranged Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2014 | 1,367 |
| 38 | Brain stem activation in spontaneous human migraine attacks | Nature Medicine | 1995 | 1,335 |
| 39 | The International Position on Laparoscopic Liver Surgery | Annals of Surgery | 2009 | 1,325 |
| 40 | Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial | Lancet, The | 2009 | 1,321 |
| 41 | Chemistry of persulfates in water and wastewater treatment: A review | Chemical Engineering Journal | 2017 | 1,320 |
| 42 | A Review on Basic Data-Driven Approaches for Industrial Process Monitoring | IEEE Transactions on Industrial Electronics | 2014 | 1,276 |
| 43 | Embolic strokes of undetermined source: the case for a new clinical construct | Lancet Neurology, The | 2014 | 1,268 |
| 44 | Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome | New England Journal of Medicine | 2013 | 1,258 |
| 45 | Common variants near MC4R are associated with fat mass, weight and risk of obesity | Nature Genetics | 2008 | 1,179 |
| 46 | The 2017 terahertz science and technology roadmap | Journal Physics D: Applied Physics | 2017 | 1,160 |
| 47 | A comparison study of basic data-driven fault diagnosis and process monitoring methods on the benchmark Tennessee Eastman process | Journal of Process Control | 2012 | 1,110 |
| 48 | Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial | Lancet Oncology, The | 2018 | 1,089 |
| 49 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 50 | A systematic review of immersive virtual reality applications for higher education: Design elements, lessons learned, and research agenda | Computers and Education | 2020 | 1,077 |
