| Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis | Molecular Biology and Evolution | 2000 | 6.9K |
| Lipid rafts and signal transduction | Nature Reviews Molecular Cell Biology | 2000 | 5K |
| The genome sequence of Drosophila melanogaster | Science | 2000 | 4.9K |
| Role of brain insulin receptor in control of body weight and reproduction | Science | 2000 | 1.7K |
| Engineering stability in gene networks by autoregulation | Nature | 2000 | 1.2K |
| SMART: a web-based tool for the study of genetically mobile domains | Nucleic Acids Research | 2000 | 939 |
| High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP | Nature Genetics | 2000 | 933 |
| Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells | Journal of Cell Biology | 2000 | 849 |
| Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11 | Journal of Cell Biology | 2000 | 812 |
| Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III | Nature | 2000 | 753 |
| Alternative pre-mRNA splicing: the logic of combinatorial control | Trends in Biochemical Sciences | 2000 | 738 |
| STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene | Nucleic Acids Research | 2000 | 651 |
| Application of multiple sequence alignment profiles to improve protein secondary structure prediction | Proteins: Structure, Function and Bioinformatics | 2000 | 626 |
| Glycosyltransferase activity of Fringe modulates Notch-Delta interactions | Nature | 2000 | 601 |
| Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages | Blood | 2000 | 562 |
| The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch | Nature | 2000 | 540 |
| Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 478 |
| p38 MAP kinases: beyond the stress response | Trends in Biochemical Sciences | 2000 | 472 |
| Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened | Cell | 2000 | 435 |
| Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation | Journal of Experimental Medicine | 2000 | 401 |
| Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta | Nature | 2000 | 383 |
| Specific chemical and structural damage to proteins produced by synchrotron radiation | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 383 |
| Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila | Molecular Cell | 2000 | 380 |
| Dpp gradient formation in the Drosophila wing imaginal disc | Cell | 2000 | 379 |
| Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts | Nature Cell Biology | 2000 | 366 |
