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| Automated protein model building combined with iterative structure refinement | Nature Structural Biology | 1999 | 2.3K |
| Phylogenetic perspectives in innate immunity | Science | 1999 | 2.1K |
| Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing | Biophysical Journal | 1999 | 1.7K |
| Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety | Nature Genetics | 1999 | 1.4K |
| Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients | Progress in Nuclear Magnetic Resonance Spectroscopy | 1999 | 1.3K |
| Twilight zone of protein sequence alignments | Protein Engineering, Design and Selection | 1999 | 1.1K |
| Oxidative phosphorylation at the fin de siècle | Science | 1999 | 1K |
| Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 980 |
| Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis | Genes and Development | 1999 | 799 |
| A perfect message: RNA surveillance and nonsense-mediated decay | Cell | 1999 | 721 |
| The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals | Nature | 1999 | 683 |
| The Rab5 effector EEA1 is a core component of endosome docking | Nature | 1999 | 676 |
| Essential role for TrkB receptors in hippocampus-mediated learning | Neuron | 1999 | 666 |
| Genome phylogeny based on gene content | Nature Genetics | 1999 | 556 |
| Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering | Trends in Biotechnology | 1999 | 534 |
| Phosphatidylinositol-3-OH kinases are Rab5 effectors | Nature Cell Biology | 1999 | 510 |
| Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles | Journal of Molecular Biology | 1999 | 482 |
| Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid | Nature | 1999 | 472 |
| Structure of importin-beta bound to the IBB domain of importin-alpha | Nature | 1999 | 451 |
| Neutral evolution of mutational robustness | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 434 |
| The role of local actin instability in axon formation | Science | 1999 | 434 |
| Adding the third dimension to virus life cycles: three-dimensional reconstruction of icosahedral viruses from cryo-electron micrographs | Microbiology and Molecular Biology Reviews | 1999 | 428 |
| Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13 | Cell | 1999 | 424 |
| Rapid modification of bacterial artificial chromosomes by ET-recombination | Nucleic Acids Research | 1999 | 417 |
