| # | Title | Journal | Year | Citations |
|---|
| 1 | Regulation of chromatin structure by site-specific histone H3 methyltransferases | Nature | 2000 | 2,497 |
| 2 | Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins | Nature | 2001 | 2,481 |
| 3 | AP-1: a double-edged sword in tumorigenesis | Nature Reviews Cancer | 2003 | 1,867 |
| 4 | Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer | Nature Genetics | 2005 | 1,710 |
| 5 | A causal role for E-cadherin in the transition from adenoma to carcinoma | Nature | 1998 | 1,559 |
| 6 | Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids | Cell | 1997 | 1,391 |
| 7 | A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins | Cell | 2018 | 1,372 |
| 8 | Reaching a Genetic and Molecular Understanding of Skeletal Development | Developmental Cell | 2002 | 1,309 |
| 9 | Molecular Mechanisms of Axon Guidance | Science | 2002 | 1,292 |
| 10 | The anaphase promoting complex/cyclosome: a machine designed to destroy | Nature Reviews Molecular Cell Biology | 2006 | 1,140 |
| 11 | Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase | Science | 2006 | 1,135 |
| 12 | The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint | Journal of Cell Biology | 2003 | 1,098 |
| 13 | Oncogene-induced senescence as an initial barrier in lymphoma development | Nature | 2005 | 1,089 |
| 14 | Cohesin mediates transcriptional insulation by CCCTC-binding factor | Nature | 2008 | 1,050 |
| 15 | Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 | Nature | 1999 | 1,036 |
| 16 | Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin | Molecular Cell | 2003 | 1,010 |
| 17 | A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing | Nature Genetics | 2007 | 998 |
| 18 | Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines | Yeast | 1999 | 946 |
| 19 | Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages | Cell | 2014 | 939 |
| 20 | Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1 | Nature | 1999 | 882 |
| 21 | The Anaphase-Promoting Complex | Molecular Cell | 2002 | 834 |
| 22 | The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells | Immunity | 2012 | 773 |
| 23 | Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase | Molecular Cell | 2007 | 770 |
| 24 | Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes | Nature | 2010 | 768 |
| 25 | Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast | Cell | 2000 | 765 |
| 26 | Autoamplification of NFATc1 expression determines its essential role in bone homeostasis | Journal of Experimental Medicine | 2005 | 758 |
| 27 | The many faces of histone lysine methylation | Current Opinion in Cell Biology | 2002 | 748 |
| 28 | BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo | Current Biology | 2007 | 748 |
| 29 | Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP | Cell | 1994 | 746 |
| 30 | Universal and Confident Phosphorylation Site Localization Using phosphoRS | Journal of Proteome Research | 2011 | 732 |
| 31 | The microbiota regulates type 2 immunity through RORγt + T cells | Science | 2015 | 709 |
| 32 | p53 is regulated by the lysine demethylase LSD1 | Nature | 2007 | 699 |
| 33 | DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells | Oncogene | 2005 | 697 |
| 34 | Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 685 |
| 35 | Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 680 |
| 36 | Un Ménage à Quatre | Cell | 2003 | 679 |
| 37 | Transferrin-polycation conjugates as carriers for DNA uptake into cells. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 678 |
| 38 | Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy | Nature Methods | 2014 | 672 |
| 39 | High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines | Cell | 1990 | 671 |
| 40 | The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene | Trends in Biochemical Sciences | 1999 | 670 |
| 41 | Two Distinct Pathways Remove Mammalian Cohesin from Chromosome Arms in Prophase and from Centromeres in Anaphase | Cell | 2000 | 667 |
| 42 | Cohesin's Binding to Chromosomes Depends on a Separate Complex Consisting of Scc2 and Scc4 Proteins | Molecular Cell | 2000 | 665 |
| 43 | Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections | Cell | 2002 | 663 |
| 44 | Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs | Cell | 1989 | 658 |
| 45 | Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter | Cell | 1999 | 652 |
| 46 | Molecular Architecture of SMC Proteins and the Yeast Cohesin Complex | Molecular Cell | 2002 | 649 |
| 47 | Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation | Nature Genetics | 1999 | 645 |
| 48 | Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal | Cell | 1993 | 640 |
| 49 | A CENTRAL ROLE FOR CENTRAL TOLERANCE | Annual Review of Immunology | 2006 | 631 |
| 50 | The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1 | Current Biology | 2007 | 627 |
