| # | Title | Journal | Year | Citations |
|---|
| 1 | MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability | Molecular Biology and Evolution | 2013 | 32,012 |
| 2 | Pathogen Recognition and Innate Immunity | Cell | 2006 | 9,878 |
| 3 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors | Nature Immunology | 2010 | 7,320 |
| 4 | Toll-like receptor signalling | Nature Reviews Immunology | 2004 | 7,318 |
| 5 | Pattern Recognition Receptors and Inflammation | Cell | 2010 | 6,978 |
| 6 | A Toll-like receptor recognizes bacterial DNA | Nature | 2000 | 5,827 |
| 7 | Cutting-edge terahertz technology | Nature Photonics | 2007 | 5,413 |
| 8 | TOLL-LIKERECEPTORS | Annual Review of Immunology | 2003 | 5,168 |
| 9 | A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines | Tetrahedron Letters | 1975 | 4,764 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 11 | Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity | Biochemical and Biophysical Research Communications | 1999 | 4,315 |
| 12 | Increased oxidative stress in obesity and its impact on metabolic syndrome | Journal of Clinical Investigation | 2004 | 4,302 |
| 13 | Toll-like receptors: critical proteins linking innate and acquired immunity | Nature Immunology | 2001 | 4,209 |
| 14 | Top 10 algorithms in data mining | Knowledge and Information Systems | 2008 | 4,153 |
| 15 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 16 | Methods in Mammalian Autophagy Research | Cell | 2010 | 3,939 |
| 17 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria | Cell | 2009 | 3,818 |
| 18 | Enhancement of Thermoelectric Efficiency in PbTe by Distortion of the Electronic Density of States | Science | 2008 | 3,442 |
| 19 | The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses | Nature Immunology | 2004 | 3,433 |
| 20 | Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses | Nature | 2006 | 3,292 |
| 21 | The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 | Nature | 2001 | 3,186 |
| 22 | Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species | Science | 2011 | 3,144 |
| 23 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 24 | Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity | Immunity | 2011 | 3,060 |
| 25 | Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components | Immunity | 1999 | 3,040 |
| 26 | Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia | Journal of Clinical Endocrinology and Metabolism | 2001 | 3,039 |
| 27 | IL-6 in Inflammation, Immunity, and Disease | Cold Spring Harbor Perspectives in Biology | 2014 | 2,943 |
| 28 | Bettering operation of Robots by learning | Journal of Field Robotics | 1984 | 2,917 |
| 29 | Protein and polymer analyses up tom/z 100 000 by laser ionization time-of-flight mass spectrometry | Rapid Communications in Mass Spectrometry | 1988 | 2,854 |
| 30 | Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients | Arteriosclerosis, Thrombosis, and Vascular Biology | 2000 | 2,826 |
| 31 | Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway | Science | 2003 | 2,808 |
| 32 | Finer features for functional microdevices | Nature | 2001 | 2,656 |
| 33 | Superimposing dynamic range | ACM Transactions on Graphics | 2008 | 2,605 |
| 34 | The Role of Atg Proteins in Autophagosome Formation | Annual Review of Cell and Developmental Biology | 2011 | 2,587 |
| 35 | ‘Green mice’ as a source of ubiquitous green cells | FEBS Letters | 1997 | 2,364 |
| 36 | Announcing the worldwide Protein Data Bank | Nature Structural and Molecular Biology | 2003 | 2,355 |
| 37 | Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota | Nature | 2013 | 2,339 |
| 38 | Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway | Nature Immunology | 2002 | 2,290 |
| 39 | IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction | Nature Immunology | 2005 | 2,254 |
| 40 | Small GTP-Binding Proteins | Physiological Reviews | 2001 | 2,235 |
| 41 | Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 | Nature | 1996 | 2,195 |
| 42 | The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 A | Science | 1996 | 2,143 |
| 43 | 5'-Triphosphate RNA Is the Ligand for RIG-I | Science | 2006 | 2,094 |
| 44 | Novel Modulator for Endothelial Adhesion Molecules | Circulation | 1999 | 2,042 |
| 45 | Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin | Nature | 1986 | 2,028 |
| 46 | TLR signaling pathways | Seminars in Immunology | 2004 | 2,017 |
| 47 | Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer | JAMA - Journal of the American Medical Association | 2017 | 2,003 |
| 48 | Discrete particle simulation of two-dimensional fluidized bed | Powder Technology | 1993 | 2,002 |
| 49 | Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids | Cell | 2010 | 2,001 |
| 50 | PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization | Trends in Biochemical Sciences | 1999 | 1,991 |
