| # | Title | Journal | Year | Citations |
|---|
| 1 | The Sequence of the Human Genome | Science | 2001 | 12,623 |
| 2 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 3 | Genome sequence of the human malaria parasite Plasmodium falciparum | Nature | 2002 | 3,881 |
| 4 | The Genome Sequence of the Malaria MosquitoAnopheles gambiae | Science | 2002 | 1,859 |
| 5 | Comparative Genomics of the Eukaryotes | Science | 2000 | 1,573 |
| 6 | The genome sequence of the filamentous fungus Neurospora crassa | Nature | 2003 | 1,528 |
| 7 | Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes | Science | 2002 | 1,432 |
| 8 | The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 1,315 |
| 9 | A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis | American Journal of Human Genetics | 2004 | 1,313 |
| 10 | Recent Segmental Duplications in the Human Genome | Science | 2002 | 1,238 |
| 11 | A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees | PLoS Biology | 2005 | 870 |
| 12 | Genome sequence of the dissimilatory metal ion–reducing bacterium Shewanella oneidensis | Nature Biotechnology | 2002 | 771 |
| 13 | Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii | Nature | 2002 | 666 |
| 14 | Whole-Genome Comparison of Mycobacterium tuberculosis Clinical and Laboratory Strains | Journal of Bacteriology | 2002 | 645 |
| 15 | A Chemosensory Gene Family Encoding Candidate Gustatory and Olfactory Receptors in Drosophila | Cell | 2001 | 636 |
| 16 | PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification | Nucleic Acids Research | 2003 | 578 |
| 17 | Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase | ChemMedChem | 2007 | 571 |
| 18 | Comparative Genome and Proteome Analysis ofAnopheles gambiaeandDrosophila melanogaster | Science | 2002 | 531 |
| 19 | Assuring the quality of next-generation sequencing in clinical laboratory practice | Nature Biotechnology | 2012 | 437 |
| 20 | Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling | Oncogene | 2003 | 421 |
| 21 | The Evolution of Cell Adhesion | Journal of Cell Biology | 2000 | 396 |
| 22 | The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic | Antiviral Research | 2010 | 386 |
| 23 | A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome | Science | 2002 | 344 |
| 24 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | Nature Biotechnology | 2004 | 320 |
| 25 | Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms | BMC Genomics | 2006 | 314 |
| 26 | Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence | Genome Biology | 2002 | 313 |
| 27 | REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis | Nature Genetics | 2009 | 305 |
| 28 | Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis | Human Molecular Genetics | 2006 | 279 |
| 29 | Drosophila melanogasterG Protein–Coupled Receptors | Journal of Cell Biology | 2000 | 252 |
| 30 | Heterochromatic sequences in a Drosophila whole-genome shotgun assembly | Genome Biology | 2002 | 232 |
| 31 | PTPN22 Genetic Variation: Evidence for Multiple Variants Associated with Rheumatoid Arthritis | American Journal of Human Genetics | 2005 | 215 |
| 32 | Chemical proteomics and its application to drug discovery | Current Opinion in Biotechnology | 2003 | 212 |
| 33 | Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse | PLoS Biology | 2004 | 210 |
| 34 | Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22 | Journal of Biological Chemistry | 2006 | 200 |
| 35 | Algorithmic strategies for the single nucleotide polymorphism haplotype assembly problem | Briefings in Bioinformatics | 2002 | 187 |
| 36 | A Survey of Human Disease Gene Counterparts in the Drosophila Genome | Journal of Cell Biology | 2000 | 185 |
| 37 | Whole-Genome Shotgun Optical Mapping of Deinococcus radiodurans | Science | 1999 | 184 |
| 38 | SCOPE: a probabilistic model for scoring tandem mass spectra against a peptide database | Bioinformatics | 2001 | 165 |
| 39 | An insight into the salivary transcriptome and proteome of the adult female mosquito Culex pipiens quinquefasciatus | Insect Biochemistry and Molecular Biology | 2004 | 149 |
| 40 | A Polymorphism in the Protease-Like Domain of Apolipoprotein(a) Is Associated With Severe Coronary Artery Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 2007 | 143 |
| 41 | Disk-Covering, a Fast-Converging Method for Phylogenetic Tree Reconstruction | Journal of Computational Biology | 1999 | 136 |
| 42 | MatchMiner: a tool for batch navigation among gene and gene product identifiers | Genome Biology | 2003 | 135 |
| 43 | A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma | Gastroenterology | 2011 | 133 |
| 44 | Enzyme activity – it's all about image | Trends in Cell Biology | 2004 | 128 |
| 45 | Plasmodium, human and Anopheles genomics and malaria | Nature | 2002 | 126 |
| 46 | Repression of AGAMOUS by BELLRINGER in Floral and Inflorescence Meristems | Plant Cell | 2004 | 126 |
| 47 | Implications of the Human Genome for Understanding Human Biology and Medicine | JAMA - Journal of the American Medical Association | 2001 | 122 |
| 48 | CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo | Molecular Cancer Therapeutics | 2006 | 117 |
| 49 | The canine olfactory subgenome | Genomics | 2004 | 114 |
| 50 | Updated European Recommendations for the Clinical Use of HIV Drug Resistance Testing | Antiviral Therapy | 2004 | 114 |
