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Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors | Cancer Discovery | 2016 | 397 |
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques | Journal of Experimental Medicine | 2016 | 367 |
Histone Modifications and Cancer | Cold Spring Harbor Perspectives in Biology | 2016 | 328 |
Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages | Brain | 2016 | 275 |
Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients | Alzheimer's and Dementia | 2016 | 241 |
Drug development in Alzheimer's disease: the path to 2025 | Alzheimer's Research and Therapy | 2016 | 234 |
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis | Nature Reviews Neuroscience | 2016 | 220 |
Cisplatin in the modern era: The backbone of first-line chemotherapy for non-small cell lung cancer | Cancer Treatment Reviews | 2016 | 213 |
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor | Biological Psychiatry | 2016 | 211 |
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation | Genome Biology | 2016 | 189 |
Photochemical Perfluoroalkylation with Pyridine -Oxides: Mechanistic Insights and Performance on a Kilogram Scale | CheM | 2016 | 170 |
Biased agonism: An emerging paradigm in GPCR drug discovery | Bioorganic and Medicinal Chemistry Letters | 2016 | 167 |
Clinical development of new drug-radiotherapy combinations | Nature Reviews Clinical Oncology | 2016 | 162 |
High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation | Neuropsychopharmacology | 2016 | 159 |
Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults | JAMA Neurology | 2016 | 157 |
A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis | British Journal of Dermatology | 2016 | 156 |
Direct in vivo evidence of activated macrophages in human osteoarthritis | Osteoarthritis and Cartilage | 2016 | 142 |
The next generation of therapeutics for chronic kidney disease | Nature Reviews Drug Discovery | 2016 | 140 |
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Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays | Clinical Chemistry | 2016 | 135 |
Can computed crystal energy landscapes help understand pharmaceutical solids? | Chemical Communications | 2016 | 116 |
Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A | Journal of Inflammation Research | 2016 | 115 |
Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies | Diabetes Care | 2016 | 113 |