| # | Title | Journal | Year | Citations |
|---|
| 1 | Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 5,183 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | GATE: a simulation toolkit for PET and SPECT | Physics in Medicine and Biology | 2004 | 1,765 |
| 4 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 5 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial | Lancet, The | 2011 | 1,663 |
| 6 | Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes | Nature Medicine | 2015 | 1,592 |
| 7 | Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing | Cell | 2012 | 1,591 |
| 8 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 9 | Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial | Journal of Clinical Oncology | 2020 | 1,255 |
| 10 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,166 |
| 11 | Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer | Nature Medicine | 2018 | 1,071 |
| 12 | Diagnostic criteria for Menière's disease | Journal of Vestibular Research: Equilibrium and Orientation | 2015 | 995 |
| 13 | International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts | Blood | 2015 | 982 |
| 14 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 15 | EML4-ALKFusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer | Clinical Cancer Research | 2008 | 916 |
| 16 | Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy | Molecular Cell | 2013 | 880 |
| 17 | Glucose Biosensors: An Overview of Use in Clinical Practice | Sensors | 2010 | 831 |
| 18 | The Epidemiology of Renal Cell Carcinoma | European Urology | 2011 | 817 |
| 19 | Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study | Journal of Clinical Oncology | 2019 | 811 |
| 20 | Mental health status of people isolated due to Middle East Respiratory Syndrome | Epidemiology and Health | 2016 | 801 |
| 21 | Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies | Nature Medicine | 2012 | 782 |
| 22 | Wound healing effect of adipose-derived stem cells: A critical role of secretory factors on human dermal fibroblasts | Journal of Dermatological Science | 2007 | 763 |
| 23 | Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib | JAMA Oncology | 2020 | 746 |
| 24 | Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer | Nature Communications | 2017 | 743 |
| 25 | Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations | Korean Journal of Radiology | 2016 | 708 |
| 26 | A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke | Stem Cells | 2010 | 694 |
| 27 | Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells | Cancer Cell | 2013 | 665 |
| 28 | The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma | Cancer Cell | 2014 | 665 |
| 29 | A living WHO guideline on drugs for covid-19 | BMJ, The | 2020 | 664 |
| 30 | Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine | Nature Medicine | 2013 | 661 |
| 31 | Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project | Blood | 2009 | 656 |
| 32 | Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 654 |
| 33 | Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1) | Cancer Discovery | 2017 | 647 |
| 34 | Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer | Nature Medicine | 2013 | 634 |
| 35 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 36 | The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer | Journal of Thoracic Oncology | 2015 | 628 |
| 37 | Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer | Journal of Clinical Oncology | 2020 | 614 |
| 38 | Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer | JAMA Oncology | 2020 | 611 |
| 39 | SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma | Cell Stem Cell | 2009 | 598 |
| 40 | Clonal evolution of glioblastoma under therapy | Nature Genetics | 2016 | 591 |
| 41 | Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia | Cell Metabolism | 2008 | 586 |
| 42 | Osteoconduction at porous hydroxyapatite with various pore configurations | Biomaterials | 2000 | 575 |
| 43 | Updated efficacy and safety data from IMbrave150: Atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma | Journal of Hepatology | 2022 | 568 |
| 44 | Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma | Nature Communications | 2020 | 565 |
| 45 | Extranodal Natural Killer T-Cell Lymphoma, Nasal-Type: A Prognostic Model From a Retrospective Multicenter Study | Journal of Clinical Oncology | 2006 | 560 |
| 46 | Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non–Small-Cell Lung Cancer and Brain Metastases | Journal of Clinical Oncology | 2015 | 555 |
| 47 | Development of aT1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles | Angewandte Chemie - International Edition | 2007 | 545 |
| 48 | Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy | Nature Genetics | 1997 | 540 |
| 49 | Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer | Nature Medicine | 2013 | 526 |
| 50 | Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells | Journal of Cell Biology | 2011 | 520 |
