| # | Title | Journal | Year | Citations |
|---|
| 1 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences | Journal of Molecular Evolution | 1980 | 25,715 |
| 2 | Evolutionary Rate at the Molecular Level | Nature | 1968 | 3,316 |
| 3 | The role of autophagy during the early neonatal starvation period | Nature | 2004 | 2,630 |
| 4 | The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression | EMBO Journal | 1986 | 2,180 |
| 5 | In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker | Molecular Biology of the Cell | 2004 | 2,115 |
| 6 | A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies | Nature | 1990 | 1,981 |
| 7 | MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis | Nature Methods | 2015 | 1,955 |
| 8 | The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants | Science | 2008 | 1,712 |
| 9 | Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice | Nature | 1995 | 1,698 |
| 10 | The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins | Science | 2002 | 1,539 |
| 11 | Inhibition of Macroautophagy Triggers Apoptosis | Molecular and Cellular Biology | 2005 | 1,533 |
| 12 | The amphioxus genome and the evolution of the chordate karyotype | Nature | 2008 | 1,496 |
| 13 | A map of rice genome variation reveals the origin of cultivated rice | Nature | 2012 | 1,428 |
| 14 | An auxin-based degron system for the rapid depletion of proteins in nonplant cells | Nature Methods | 2009 | 1,364 |
| 15 | Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting | Nature | 2004 | 1,242 |
| 16 | The genome of the social amoeba Dictyostelium discoideum | Nature | 2005 | 1,179 |
| 17 | Highly inclined thin illumination enables clear single-molecule imaging in cells | Nature Methods | 2008 | 1,109 |
| 18 | The minimum information about a genome sequence (MIGS) specification | Nature Biotechnology | 2008 | 1,069 |
| 19 | A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population | Genetical Research | 1973 | 1,058 |
| 20 | The medaka draft genome and insights into vertebrate genome evolution | Nature | 2007 | 1,037 |
| 21 | Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D | Nature | 2004 | 1,016 |
| 22 | Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes | Nature | 2008 | 1,007 |
| 23 | Slightly Deleterious Mutant Substitutions in Evolution | Nature | 1973 | 1,002 |
| 24 | Efficient de novo assembly of highly heterozygous genomes from whole-genome shotgun short reads | Genome Research | 2014 | 1,000 |
| 25 | Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome | Cell | 2017 | 973 |
| 26 | Sex Determination: Why So Many Ways of Doing It? | PLoS Biology | 2014 | 916 |
| 27 | Simple methods for testing the molecular evolutionary clock hypothesis. | Genetics | 1993 | 866 |
| 28 | Genome evolution in the allotetraploid frog Xenopus laevis | Nature | 2016 | 849 |
| 29 | The sequence read archive: explosive growth of sequencing data | Nucleic Acids Research | 2012 | 841 |
| 30 | Autophagosome Formation in Mammalian Cells. | Cell Structure and Function | 2002 | 833 |
| 31 | Growth Phase-Dependent Variation in Protein Composition of the Escherichia coli Nucleoid | Journal of Bacteriology | 1999 | 787 |
| 32 | DFAST: a flexible prokaryotic genome annotation pipeline for faster genome publication | Bioinformatics | 2018 | 775 |
| 33 | A Transposon-Mediated Gene Trap Approach Identifies Developmentally Regulated Genes in Zebrafish | Developmental Cell | 2004 | 767 |
| 34 | Using the Acropora digitifera genome to understand coral responses to environmental change | Nature | 2011 | 758 |
| 35 | Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity | Nature | 2022 | 756 |
| 36 | Epigenetic events in mammalian germ-cell development: reprogramming and beyond | Nature Reviews Genetics | 2008 | 752 |
| 37 | Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer | Nature Medicine | 2019 | 748 |
| 38 | A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase | Science | 1993 | 745 |
| 39 | The dynamic genome of Hydra | Nature | 2010 | 743 |
| 40 | The future of biocuration | Nature | 2008 | 648 |
| 41 | AN APPROACH TO POPULATION AND EVOLUTIONARY GENETIC THEORY FOR GENES IN MITOCHONDRIA AND CHLOROPLASTS, AND SOME RESULTS | Genetics | 1983 | 647 |
| 42 | Rice Plant Development: from Zygote to Spikelet | Plant and Cell Physiology | 2005 | 628 |
| 43 | Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability | American Journal of Pathology | 2007 | 621 |
| 44 | Diffusion models in population genetics | Journal of Applied Probability | 1964 | 614 |
| 45 | Population Biology of Antigen Presentation by MHC Class I Molecules | Science | 1996 | 613 |
| 46 | Histone lysine methylation: a signature for chromatin function | Trends in Genetics | 2003 | 613 |
| 47 | The African coelacanth genome provides insights into tetrapod evolution | Nature | 2013 | 612 |
| 48 | Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis | Nature | 2001 | 610 |
| 49 | THE AVERAGE NUMBER OF GENERATIONS UNTIL FIXATION OF A MUTANT GENE IN A FINITE POPULATION | Genetics | 1969 | 600 |
| 50 | Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution | Nature | 1977 | 587 |
