| # | Title | Journal | Year | Citations |
|---|
| 1 | International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) | Journal of Thrombosis and Haemostasis | 2006 | 6,039 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 4 | Adherence to a Mediterranean Diet and Survival in a Greek Population | New England Journal of Medicine | 2003 | 3,513 |
| 5 | International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma | Lancet Oncology, The | 2014 | 3,343 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 7 | Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis | Brain, Behavior, and Immunity | 2020 | 2,517 |
| 8 | Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations | American Journal of Respiratory and Critical Care Medicine | 2016 | 2,385 |
| 9 | Stress and disorders of the stress system | Nature Reviews Endocrinology | 2009 | 2,235 |
| 10 | Differences Between Tight and Loose Cultures: A 33-Nation Study | Science | 2011 | 2,075 |
| 11 | Machine learning applications in cancer prognosis and prediction | Computational and Structural Biotechnology Journal | 2015 | 2,059 |
| 12 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 13 | Reconfigurable Intelligent Surfaces for Energy Efficiency in Wireless Communication | IEEE Transactions on Wireless Communications | 2019 | 2,003 |
| 14 | Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor | Nature Medicine | 2004 | 1,920 |
| 15 | 2020 International Society of Hypertension Global Hypertension Practice Guidelines | Hypertension | 2020 | 1,895 |
| 16 | Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Nature | 2005 | 1,870 |
| 17 | International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma | Lancet Oncology, The | 2016 | 1,866 |
| 18 | Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline | Journal of Clinical Endocrinology and Metabolism | 2006 | 1,811 |
| 19 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
| 20 | Genomic instability — an evolving hallmark of cancer | Nature Reviews Molecular Cell Biology | 2010 | 1,798 |
| 21 | Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints | Nature | 2006 | 1,777 |
| 22 | Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure | Cell Host and Microbe | 2020 | 1,746 |
| 23 | Superclusteroid: a Web tool dedicated to data processing of protein-protein interaction networks | EMBnet Journal | 2011 | 1,728 |
| 24 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
| 25 | The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report | Fertility and Sterility | 2009 | 1,639 |
| 26 | An Oncogene-Induced DNA Damage Model for Cancer Development | Science | 2008 | 1,612 |
| 27 | Cellular Senescence: Defining a Path Forward | Cell | 2019 | 1,551 |
| 28 | No saturation in the accumulation of alien species worldwide | Nature Communications | 2017 | 1,543 |
| 29 | European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection | Public Health Nutrition | 2002 | 1,539 |
| 30 | mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity | Science | 2014 | 1,517 |
| 31 | Nurse staffing and education and hospital mortality in nine European countries: a retrospective observational study | Lancet, The | 2014 | 1,497 |
| 32 | 8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis | Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews | 2009 | 1,460 |
| 33 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 34 | Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria | Movement Disorders | 2017 | 1,402 |
| 35 | Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants | Ecotoxicology and Environmental Safety | 2006 | 1,375 |
| 36 | Chaos-based communications at high bit rates using commercial fibre-optic links | Nature | 2005 | 1,365 |
| 37 | Hematological findings and complications of COVID‐19 | American Journal of Hematology | 2020 | 1,354 |
| 38 | Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity | Science | 2014 | 1,338 |
| 39 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 40 | Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study | CardioVascular and Interventional Radiology | 2010 | 1,329 |
| 41 | Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases | Lancet Infectious Diseases, The | 2013 | 1,328 |
| 42 | Patient safety, satisfaction, and quality of hospital care: cross sectional surveys of nurses and patients in 12 countries in Europe and the United States | BMJ: British Medical Journal | 2012 | 1,321 |
| 43 | Polymers with Complex Architecture by Living Anionic Polymerization | Chemical Reviews | 2001 | 1,274 |
| 44 | Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease) | Lancet, The | 2000 | 1,270 |
| 45 | 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 1,265 |
| 46 | First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial | Lancet, The | 2021 | 1,237 |
| 47 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 48 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision | Journal of Allergy and Clinical Immunology | 2017 | 1,199 |
| 49 | Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial | Lancet, The | 2015 | 1,175 |
| 50 | Cooling the cities – A review of reflective and green roof mitigation technologies to fight heat island and improve comfort in urban environments | Solar Energy | 2014 | 1,172 |
