| # | Title | Journal | Year | Citations |
|---|
| 1 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets | Nature Communications | 2019 | 7,886 |
| 2 | The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity | Nature | 2012 | 6,473 |
| 3 | Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 2,198 |
| 4 | ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures | Cell | 2003 | 2,180 |
| 5 | A TRP Channel that Senses Cold Stimuli and Menthol | Cell | 2002 | 1,972 |
| 6 | Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus | Pediatrics | 2005 | 1,920 |
| 7 | Genomics, gene expression and DNA arrays | Nature | 2000 | 1,893 |
| 8 | ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells | Biology of Blood and Marrow Transplantation | 2019 | 1,741 |
| 9 | Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations | Neoplasia | 2009 | 1,703 |
| 10 | Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin | Neuron | 2004 | 1,599 |
| 11 | Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer | New England Journal of Medicine | 2019 | 1,582 |
| 12 | Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock | Science | 2000 | 1,539 |
| 13 | Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas | New England Journal of Medicine | 2017 | 1,390 |
| 14 | More than 50 long-term effects of COVID-19: a systematic review and meta-analysis | Scientific Reports | 2021 | 1,358 |
| 15 | Expanding the Genetic Code of Escherichia coli | Science | 2001 | 1,341 |
| 16 | COT drives resistance to RAF inhibition through MAP kinase pathway reactivation | Nature | 2010 | 1,325 |
| 17 | Prodrugs: design and clinical applications | Nature Reviews Drug Discovery | 2008 | 1,253 |
| 18 | BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources | Genome Biology | 2009 | 1,216 |
| 19 | Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial | Lancet, The | 2015 | 1,175 |
| 20 | Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 1,132 |
| 21 | Salt formation to improve drug solubility | Advanced Drug Delivery Reviews | 2007 | 1,111 |
| 22 | Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis | Nature Reviews Drug Discovery | 2010 | 1,070 |
| 23 | Spiroindolones, a Potent Compound Class for the Treatment of Malaria | Science | 2010 | 1,031 |
| 24 | A chemical switch for inhibitor-sensitive alleles of any protein kinase | Nature | 2000 | 1,001 |
| 25 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial | Lancet, The | 2012 | 990 |
| 26 | Rational design of inhibitors that bind to inactive kinase conformations | Nature Chemical Biology | 2006 | 985 |
| 27 | Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study | Lancet, The | 2016 | 962 |
| 28 | ESR1 ligand-binding domain mutations in hormone-resistant breast cancer | Nature Genetics | 2013 | 960 |
| 29 | First-line ceritinib versus platinum-based chemotherapy in advanced ALK -rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study | Lancet, The | 2017 | 919 |
| 30 | A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock | Neuron | 2004 | 909 |
| 31 | Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells | Science | 2010 | 904 |
| 32 | The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis | Experimental Dermatology | 2001 | 897 |
| 33 | Dabrafenib plus trametinib in patients with previously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial | Lancet Oncology, The | 2017 | 889 |
| 34 | Comparative genomics: the bacterial pan-genome | Current Opinion in Microbiology | 2008 | 868 |
| 35 | Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding | Cell Host and Microbe | 2015 | 868 |
| 36 | Methods for evaluation of medication adherence and persistence using automated databases | Pharmacoepidemiology and Drug Safety | 2006 | 867 |
| 37 | Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma | Cancer | 2003 | 836 |
| 38 | A Heat-Sensitive TRP Channel Expressed in Keratinocytes | Science | 2002 | 828 |
| 39 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial | Lancet, The | 2013 | 810 |
| 40 | c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function | Molecular Cell | 2002 | 809 |
| 41 | Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial Commentary: Another piece of the Alzheimer's jigsaw | BMJ: British Medical Journal | 1999 | 782 |
| 42 | A standard curve based method for relative real time PCR data processing | BMC Bioinformatics | 2005 | 780 |
| 43 | TRPM8 Is Required for Cold Sensation in Mice | Neuron | 2007 | 777 |
| 44 | Medical Therapy for Heart Failure With Reduced Ejection Fraction | Journal of the American College of Cardiology | 2018 | 775 |
| 45 | Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis | Science Translational Medicine | 2010 | 774 |
| 46 | Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting | Science | 2002 | 768 |
| 47 | Polymorphs, Salts, and Cocrystals: What’s in a Name? | Crystal Growth and Design | 2012 | 767 |
| 48 | Human host factors required for influenza virus replication | Nature | 2010 | 755 |
| 49 | Replication Dynamics of the Yeast Genome | Science | 2001 | 736 |
| 50 | ThermoTRP channels and beyond: mechanisms of temperature sensation | Nature Reviews Neuroscience | 2003 | 722 |
