Angiotensin-neprilysin inhibition versus enalapril in heart failure | New England Journal of Medicine | 2014 | 3.3K |
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer | Cancer Discovery | 2014 | 591 |
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial | Lancet Neurology, The | 2014 | 572 |
Impaired systolic function by strain imaging in heart failure with preserved ejection fraction | Journal of the American College of Cardiology | 2014 | 439 |
Piezo2 is the major transducer of mechanical forces for touch sensation in mice | Nature | 2014 | 439 |
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial | JAMA - Journal of the American Medical Association | 2014 | 427 |
Piezo1, a mechanically activated ion channel, is required for vascular development in mice | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 424 |
Piezo2 is required for Merkel-cell mechanotransduction | Nature | 2014 | 418 |
mTOR inhibition improves immune function in the elderly | Science Translational Medicine | 2014 | 407 |
Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2† | Annals of Oncology | 2014 | 361 |
Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet Oncology, The | 2014 | 359 |
SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel | Cell | 2014 | 336 |
Pasireotide versus octreotide in acromegaly: a head-to-head superiority study | Journal of Clinical Endocrinology and Metabolism | 2014 | 254 |
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias | PLoS Genetics | 2014 | 219 |
Determinants and outcomes of physical activity in patients with COPD: a systematic review | Thorax | 2014 | 219 |
Use of historical control data for assessing treatment effects in clinical trials | Pharmaceutical Statistics | 2014 | 218 |
Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis | Chemical Reviews | 2014 | 217 |
Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial | Lancet Oncology, The | 2014 | 215 |
Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial | Lancet, The | 2014 | 212 |
Interleukin 17A: toward a new understanding of psoriasis pathogenesis | Journal of the American Academy of Dermatology | 2014 | 206 |
A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas | European Journal of Cancer | 2014 | 203 |
Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 197 |
Early molecular response predicts outcomes in patients with chronic myeloid leukemia in chronic phase treated with frontline nilotinib or imatinib | Blood | 2014 | 196 |
KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features | PLoS Pathogens | 2014 | 195 |
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein | Cell Reports | 2014 | 185 |