| # | Title | Journal | Year | Citations |
|---|
| 1 | Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries | JAMA - Journal of the American Medical Association | 2016 | 3,568 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score | Intensive Care Medicine | 2000 | 1,183 |
| 4 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology | Ultraschall in Der Medizin | 2013 | 961 |
| 5 | A Comparison of Noninvasive Positive-Pressure Ventilation and Conventional Mechanical Ventilation in Patients with Acute Respiratory Failure | New England Journal of Medicine | 1998 | 924 |
| 6 | FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study | Lancet Oncology, The | 2015 | 835 |
| 7 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography.Part 2: Clinical Applications | Ultraschall in Der Medizin | 2013 | 780 |
| 8 | EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version) | Ultraschall in Der Medizin | 2017 | 659 |
| 9 | The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version) | Ultraschall in Der Medizin | 2018 | 627 |
| 10 | Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy | Nature Genetics | 2007 | 624 |
| 11 | Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock | JAMA - Journal of the American Medical Association | 2013 | 542 |
| 12 | Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis | European Radiology | 2020 | 530 |
| 13 | Control of cccDNA function in hepatitis B virus infection | Journal of Hepatology | 2009 | 476 |
| 14 | Risk factors for hip fracture in european women: The MEDOS study | Journal of Bone and Mineral Research | 1995 | 472 |
| 15 | Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial | Lancet Oncology, The | 2013 | 472 |
| 16 | Diagnosis and treatment of diverticular disease | Surgical Endoscopy and Other Interventional Techniques | 1999 | 463 |
| 17 | Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study | American Journal of Respiratory and Critical Care Medicine | 2017 | 456 |
| 18 | Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway | Science | 1997 | 450 |
| 19 | p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps | Molecular and Cellular Biology | 2000 | 419 |
| 20 | Mapping and predicting mortality from systemic sclerosis | Annals of the Rheumatic Diseases | 2017 | 410 |
| 21 | Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis | Annals of the American Thoracic Society | 2017 | 400 |
| 22 | Differential Roles of p300 and PCAF Acetyltransferases in Muscle Differentiation | Molecular Cell | 1997 | 398 |
| 23 | Second-Generation Drug-Eluting Stent Implantation Followed by 6- Versus 12-Month Dual Antiplatelet Therapy | Journal of the American College of Cardiology | 2014 | 388 |
| 24 | Coronary microvascular dysfunction: mechanisms and functional assessment | Nature Reviews Cardiology | 2015 | 377 |
| 25 | Regulation of the p300 HAT domain via a novel activation loop | Nature Structural and Molecular Biology | 2004 | 374 |
| 26 | Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial | Lancet, The | 2018 | 373 |
| 27 | The Controversial Relationship Between Benign Prostatic Hyperplasia and Prostate Cancer: The Role of Inflammation | European Urology | 2011 | 351 |
| 28 | Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) | Frontiers in Immunology | 2020 | 348 |
| 29 | Thrombus Aspiration During Primary Percutaneous Coronary Intervention Improves Myocardial Reperfusion and Reduces Infarct Size | Journal of the American College of Cardiology | 2009 | 341 |
| 30 | Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial | Intensive Care Medicine | 2002 | 333 |
| 31 | Gastroesophageal reflux disease and Barrett’s esophagus after laparoscopic sleeve gastrectomy: a possible, underestimated long-term complication | Surgery for Obesity and Related Diseases | 2017 | 333 |
| 32 | Pollen-related allergy in Europe | Allergy: European Journal of Allergy and Clinical Immunology | 1998 | 321 |
| 33 | Epicardial Adipose Tissue and Insulin Resistance in Obese Subjects | Journal of Clinical Endocrinology and Metabolism | 2005 | 315 |
| 34 | Risk Factors for Hip Fracture in Men from Southern Europe: The MEDOS Study | Osteoporosis International | 1999 | 308 |
| 35 | Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 285 |
| 36 | Evaluation of Crohn disease activity with magnetic resonance imaging | Abdominal Imaging | 2000 | 274 |
| 37 | The variable incidence of hip fracture in Southern Europe: The MEDOS study | Osteoporosis International | 1994 | 266 |
| 38 | PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV | Journal of Clinical Investigation | 2009 | 262 |
| 39 | Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism | Oncogene | 1999 | 261 |
| 40 | Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion | Blood | 2017 | 261 |
| 41 | GermlineBRAFmutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum | Human Mutation | 2009 | 251 |
| 42 | Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study | Intensive Care Medicine | 2016 | 247 |
| 43 | Case Fatality Rates for Patients with COVID-19 Requiring Invasive Mechanical Ventilation. A Meta-analysis | American Journal of Respiratory and Critical Care Medicine | 2021 | 243 |
| 44 | Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for TreatingEnterococcus faecalisInfective Endocarditis | Clinical Infectious Diseases | 2013 | 241 |
| 45 | Practice patterns in the management of acute renal failure in the critically ill patient: an international survey | Nephrology Dialysis Transplantation | 2006 | 237 |
| 46 | Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes | Surgical Endoscopy and Other Interventional Techniques | 2010 | 234 |
| 47 | Nutritional status: its influence on the outcome of patients undergoing liver transplantation | Liver International | 2010 | 233 |
| 48 | Expression of Functional Leptin Receptors in Rodent Leydig Cells1 | Endocrinology | 1999 | 229 |
| 49 | Adjunctive manual thrombectomy improves myocardial perfusion and mortality in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis of randomized trials | European Heart Journal | 2008 | 229 |
| 50 | GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients | European Journal of Clinical Investigation | 2004 | 228 |
