| # | Title | Journal | Year | Citations |
|---|
| 1 | Acute Respiratory Distress Syndrome | JAMA - Journal of the American Medical Association | 2012 | 6,995 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2018 | 4,701 |
| 5 | Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Nature | 1995 | 3,894 |
| 6 | A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD | Neuron | 2011 | 3,833 |
| 7 | Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention | Nature Reviews Gastroenterology and Hepatology | 2018 | 3,487 |
| 8 | Global Prevalence and Major Risk Factors of Diabetic Retinopathy | Diabetes Care | 2012 | 3,439 |
| 9 | International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma | Lancet Oncology, The | 2014 | 3,343 |
| 10 | A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis | Nature | 1997 | 3,342 |
| 11 | Synaptic Pruning by Microglia Is Necessary for Normal Brain Development | Science | 2011 | 3,138 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 13 | Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2008 | 3,032 |
| 14 | Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer | New England Journal of Medicine | 2003 | 2,930 |
| 15 | Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2018 | 2,676 |
| 16 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 17 | TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data | Nucleic Acids Research | 2016 | 2,519 |
| 18 | The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD | Hepatology | 2007 | 2,448 |
| 19 | International uniform response criteria for multiple myeloma | Leukemia | 2006 | 2,332 |
| 20 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome | Hepatology | 2003 | 2,276 |
| 21 | Lung cancer: current therapies and new targeted treatments | Lancet, The | 2017 | 2,267 |
| 22 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis | Gastroenterology | 2013 | 2,211 |
| 23 | A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement | Journal of Hepatology | 2020 | 2,171 |
| 24 | Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group | Journal of Clinical Oncology | 2008 | 2,119 |
| 25 | Multiple Myeloma | New England Journal of Medicine | 2011 | 2,109 |
| 26 | Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome | Diabetes | 2001 | 2,100 |
| 27 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Intensive Care Medicine | 2008 | 2,078 |
| 28 | Ventilator-Induced Lung Injury | New England Journal of Medicine | 2013 | 2,030 |
| 29 | RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease | Nature | 1996 | 1,947 |
| 30 | Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group | British Journal of Haematology | 2003 | 1,887 |
| 31 | Stability of a Schwarzschild Singularity | Physical Review | 1957 | 1,870 |
| 32 | International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma | Lancet Oncology, The | 2016 | 1,866 |
| 33 | IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy | Nature Genetics | 2009 | 1,808 |
| 34 | BORIS: a free, versatile open‐source event‐logging software for video/audio coding and live observations | Methods in Ecology and Evolution | 2016 | 1,798 |
| 35 | Antibodies to major histocompatibility antigens produced by hybrid cell lines | Nature | 1977 | 1,769 |
| 36 | Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR | Nature | 2012 | 1,769 |
| 37 | Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2012 | 1,752 |
| 38 | European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013 | Blood | 2013 | 1,743 |
| 39 | Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials | Lancet, The | 2011 | 1,711 |
| 40 | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer | Nature | 2012 | 1,605 |
| 41 | IKK-β links inflammation to obesity-induced insulin resistance | Nature Medicine | 2005 | 1,591 |
| 42 | Gaia Data Release 2 | Astronomy and Astrophysics | 2018 | 1,576 |
| 43 | Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2018 | 1,571 |
| 44 | Forest disturbances under climate change | Nature Climate Change | 2017 | 1,561 |
| 45 | Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer | Journal of Clinical Oncology | 2008 | 1,540 |
| 46 | European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection | Public Health Nutrition | 2002 | 1,539 |
| 47 | Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer | Journal of Clinical Oncology | 2018 | 1,525 |
| 48 | Nilotinib versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia | New England Journal of Medicine | 2010 | 1,497 |
| 49 | MOLCAS 7: The Next Generation | Journal of Computational Chemistry | 2010 | 1,485 |
| 50 | Liquid biopsy: monitoring cancer-genetics in the blood | Nature Reviews Clinical Oncology | 2013 | 1,482 |
