| # | Title | Journal | Year | Citations |
|---|
| 1 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial | Lancet, The | 2010 | 5,899 |
| 2 | Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial | Lancet, The | 2017 | 3,224 |
| 3 | Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma | New England Journal of Medicine | 2017 | 2,677 |
| 4 | Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation | Circulation: Arrhythmia and Electrophysiology | 2010 | 1,962 |
| 5 | AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 1,802 |
| 6 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,760 |
| 7 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 8 | The neurobiology of zinc in health and disease | Nature Reviews Neuroscience | 2005 | 1,633 |
| 9 | Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer | New England Journal of Medicine | 2015 | 1,526 |
| 10 | Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer | New England Journal of Medicine | 2020 | 1,513 |
| 11 | TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity | Nature | 2007 | 1,405 |
| 12 | ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death | Nature Cell Biology | 2013 | 1,315 |
| 13 | International Consensus Diagnostic Criteria for Autoimmune Pancreatitis | Pancreas | 2011 | 1,280 |
| 14 | Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2019 | 1,202 |
| 15 | MX2semiconductors (M=Mo, W;Thickness and strain effects on electronic structures of transition metal dichalcogenides: 2H-MX2semiconductors (M=Mo, W; | Physical Review B | 2012 | 1,126 |
| 16 | Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer | Nature Genetics | 2012 | 1,049 |
| 17 | KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | New England Journal of Medicine | 2020 | 1,049 |
| 18 | Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report | American Journal of Respiratory and Critical Care Medicine | 2016 | 1,006 |
| 19 | Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study | Journal of Clinical Oncology | 2011 | 1,003 |
| 20 | Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2013 | 999 |
| 21 | Acute Exacerbations of Idiopathic Pulmonary Fibrosis | American Journal of Respiratory and Critical Care Medicine | 2007 | 996 |
| 22 | High‐Detectivity Multilayer MoS2 Phototransistors with Spectral Response from Ultraviolet to Infrared | Advanced Materials | 2012 | 970 |
| 23 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits | Nature Genetics | 2009 | 937 |
| 24 | Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer | New England Journal of Medicine | 2019 | 918 |
| 25 | Three-Year, Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema | Ophthalmology | 2014 | 909 |
| 26 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update | Hepatology International | 2012 | 874 |
| 27 | Conformal quantum dot–SnO 2 layers as electron transporters for efficient perovskite solar cells | Science | 2022 | 872 |
| 28 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial | Lancet Oncology, The | 2010 | 852 |
| 29 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 836 |
| 30 | Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? | Journal of Signal Transduction | 2011 | 824 |
| 31 | Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML | New England Journal of Medicine | 2019 | 796 |
| 32 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 761 |
| 33 | α-Fe 2 O 3 as a photocatalytic material: A review | Applied Catalysis A: General | 2015 | 760 |
| 34 | Left Ventricular Apical Ballooning Due to Severe Physical Stress in Patients Admitted to the Medical ICU | Chest | 2005 | 751 |
| 35 | Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib | JAMA Oncology | 2020 | 746 |
| 36 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial | Lancet Oncology, The | 2013 | 740 |
| 37 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial | Lancet Neurology, The | 2008 | 732 |
| 38 | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial | Lancet Oncology, The | 2014 | 713 |
| 39 | Hybrid Germanium Iodide Perovskite Semiconductors: Active Lone Pairs, Structural Distortions, Direct and Indirect Energy Gaps, and Strong Nonlinear Optical Properties | Journal of the American Chemical Society | 2015 | 710 |
| 40 | Early Surgery versus Conventional Treatment for Infective Endocarditis | New England Journal of Medicine | 2012 | 703 |
| 41 | Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial | Journal of Clinical Oncology | 2013 | 678 |
| 42 | Self-Organization in Coordination-Driven Self-Assembly | Accounts of Chemical Research | 2009 | 670 |
| 43 | Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine | Nature Medicine | 2013 | 661 |
| 44 | In Vivo Diagnosis of Plaque Erosion and Calcified Nodule in Patients With Acute Coronary Syndrome by Intravascular Optical Coherence Tomography | Journal of the American College of Cardiology | 2013 | 648 |
| 45 | Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors | Investigational New Drugs | 2017 | 647 |
| 46 | A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas | American Journal of Surgical Pathology | 2015 | 626 |
| 47 | Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci | Nature Genetics | 2016 | 617 |
| 48 | Free Hand Pedicle Screw Placement in the Thoracic Spine: Is it Safe? | Spine | 2004 | 602 |
| 49 | Stimuli-responsive molecular brushes | Progress in Polymer Science | 2010 | 600 |
| 50 | MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program | Blood | 2013 | 596 |
