| # | Title | Journal | Year | Citations |
|---|
| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density | Cell | 1997 | 4,620 |
| 2 | Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease | New England Journal of Medicine | 2017 | 4,179 |
| 3 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 4 | Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies | Science Translational Medicine | 2014 | 3,665 |
| 5 | OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis | Nature | 1999 | 3,093 |
| 6 | A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases | ACS Combinatorial Science | 1999 | 2,037 |
| 7 | Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer | New England Journal of Medicine | 2013 | 1,971 |
| 8 | Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand | Nature | 1999 | 1,809 |
| 9 | A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis | New England Journal of Medicine | 2000 | 1,776 |
| 10 | The Seattle Heart Failure Model | Circulation | 2006 | 1,744 |
| 11 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 12 | Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing | Cell | 2017 | 1,540 |
| 13 | The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers | Nature | 2012 | 1,506 |
| 14 | Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia | New England Journal of Medicine | 2017 | 1,443 |
| 15 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 16 | Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor | Cell | 1990 | 1,406 |
| 17 | PI3K and cancer: lessons, challenges and opportunities | Nature Reviews Drug Discovery | 2014 | 1,398 |
| 18 | The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity | Nature | 2019 | 1,375 |
| 19 | Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer | New England Journal of Medicine | 1991 | 1,342 |
| 20 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 21 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 22 | A role for melanin-concentrating hormone in the central regulation of feeding behaviour | Nature | 1996 | 1,259 |
| 23 | Prodrugs: design and clinical applications | Nature Reviews Drug Discovery | 2008 | 1,253 |
| 24 | Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells | Science | 1986 | 1,230 |
| 25 | Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo | Cell | 1998 | 1,224 |
| 26 | Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture | Cell | 1992 | 1,203 |
| 27 | Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation | Pharmaceutical Research | 2003 | 1,179 |
| 28 | Dickkopf-1 is a master regulator of joint remodeling | Nature Medicine | 2007 | 1,161 |
| 29 | Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy | Cell | 2017 | 1,124 |
| 30 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 31 | Cystatin C and the Risk of Death and Cardiovascular Events among Elderly Persons | New England Journal of Medicine | 2005 | 1,109 |
| 32 | Denosumab in Postmenopausal Women with Low Bone Mineral Density | New England Journal of Medicine | 2006 | 1,107 |
| 33 | Leptin regulation of bone resorption by the sympathetic nervous system and CART | Nature | 2005 | 1,105 |
| 34 | KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | New England Journal of Medicine | 2020 | 1,049 |
| 35 | The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption | Journal of Bone and Mineral Research | 2000 | 1,031 |
| 36 | RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 1,004 |
| 37 | “Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’ | Current Medicinal Chemistry | 2003 | 985 |
| 38 | EFFECT OF HUMAN ERYTHROPOIETIN DERIVED FROM RECOMBINANT DNA ON THE ANAEMIA OF PATIENTS MAINTAINED BY CHRONIC HAEMODIALYSIS | Lancet, The | 1986 | 978 |
| 39 | Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist | Arthritis and Rheumatism | 1998 | 920 |
| 40 | Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands | Journal of Cell Biology | 2004 | 895 |
| 41 | Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease | Annals of Neurology | 2006 | 890 |
| 42 | Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. | Molecular and Cellular Biology | 1994 | 888 |
| 43 | Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. | Genes and Development | 1995 | 815 |
| 44 | Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients | JAMA - Journal of the American Medical Association | 2016 | 813 |
| 45 | Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis | New England Journal of Medicine | 2012 | 805 |
| 46 | Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium | Cell | 1990 | 797 |
| 47 | Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers | New England Journal of Medicine | 2004 | 791 |
| 48 | Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial | Lancet, The | 2008 | 784 |
| 49 | CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome | Science | 1993 | 776 |
| 50 | Analyzing Learned Molecular Representations for Property Prediction | Journal of Chemical Information and Modeling | 2019 | 773 |
