| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2007 WHO Classification of Tumours of the Central Nervous System | Acta Neuropathologica | 2007 | 9,898 |
| 2 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 3 | Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. | Journal of Cell Biology | 1988 | 3,820 |
| 4 | Self-consistent-charge density-functional tight-binding method for simulations of complex materials properties | Physical Review B | 1998 | 3,459 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | Estimating kinetic parameters from dynamic contrast-enhanced t1-weighted MRI of a diffusable tracer: Standardized quantities and symbols | Journal of Magnetic Resonance Imaging | 1999 | 2,856 |
| 7 | Two CD95 (APO-1/Fas) signaling pathways | EMBO Journal | 1998 | 2,648 |
| 8 | nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation | Nature Methods | 2021 | 2,456 |
| 9 | Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks | Nature Medicine | 2001 | 2,352 |
| 10 | Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma | New England Journal of Medicine | 2014 | 2,078 |
| 11 | Variance stabilization applied to microarray data calibration and to the quantification of differential expression | Bioinformatics | 2002 | 2,012 |
| 12 | Monoclonal antibody-mediated tumor regression by induction of apoptosis | Science | 1989 | 1,723 |
| 13 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 14 | Characterization of extracellular circulating microRNA | Nucleic Acids Research | 2011 | 1,665 |
| 15 | Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) | Nature | 1995 | 1,625 |
| 16 | TERT Promoter Mutations in Familial and Sporadic Melanoma | Science | 2013 | 1,574 |
| 17 | CD95's deadly mission in the immune system | Nature | 2000 | 1,567 |
| 18 | Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5—a population-based study | Lancet Oncology, The | 2014 | 1,554 |
| 19 | Molecular subgroups of medulloblastoma: the current consensus | Acta Neuropathologica | 2012 | 1,536 |
| 20 | Netting neutrophils in autoimmune small-vessel vasculitis | Nature Medicine | 2009 | 1,390 |
| 21 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 | JAMA Oncology | 2018 | 1,260 |
| 22 | Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors | Nature | 1997 | 1,256 |
| 23 | Statistical shape models for 3D medical image segmentation: A review | Medical Image Analysis | 2009 | 1,154 |
| 24 | Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 | Nature Medicine | 2006 | 1,129 |
| 25 | Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth | Science | 2011 | 1,125 |
| 26 | The IARC TP53 database: New online mutation analysis and recommendations to users | Human Mutation | 2002 | 1,107 |
| 27 | FLICE is activated by association with the CD95 death-inducing signaling complex (DISC) | EMBO Journal | 1997 | 1,073 |
| 28 | Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation | PLoS Biology | 2012 | 1,064 |
| 29 | Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see) | Nature Reviews Immunology | 2014 | 1,043 |
| 30 | Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas | Acta Neuropathologica | 2009 | 1,020 |
| 31 | DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival | Cell | 1998 | 1,009 |
| 32 | Fragmentation pathways of protonated peptides | Mass Spectrometry Reviews | 2005 | 993 |
| 33 | Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells | Nature Medicine | 1996 | 943 |
| 34 | Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self | Nature Immunology | 2001 | 933 |
| 35 | Chapter 1: HPV in the etiology of human cancer | Vaccine | 2006 | 933 |
| 36 | Deep Learning Techniques for Automatic MRI Cardiac Multi-Structures Segmentation and Diagnosis: Is the Problem Solved? | IEEE Transactions on Medical Imaging | 2018 | 926 |
| 37 | Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay | Nature Biotechnology | 2013 | 920 |
| 38 | The DNA methyltransferase family: a versatile toolkit for epigenetic regulation | Nature Reviews Genetics | 2018 | 919 |
| 39 | Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma | Acta Neuropathologica | 2011 | 914 |
| 40 | Analysis of the IDH1 codon 132 mutation in brain tumors | Acta Neuropathologica | 2008 | 910 |
| 41 | Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke | Nature Medicine | 2009 | 908 |
| 42 | HDAC family: What are the cancer relevant targets? | Cancer Letters | 2009 | 893 |
| 43 | Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion? | Nature Medicine | 1996 | 872 |
| 44 | The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer | European Journal of Nuclear Medicine and Molecular Imaging | 2015 | 866 |
| 45 | Function and biological roles of the Dickkopf family of Wnt modulators | Oncogene | 2006 | 865 |
| 46 | Comparison and Evaluation of Methods for Liver Segmentation From CT Datasets | IEEE Transactions on Medical Imaging | 2009 | 848 |
| 47 | Apoptosis signaling by death receptors | FEBS Journal | 1998 | 847 |
| 48 | Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. | Genes and Development | 1995 | 820 |
| 49 | Recent cancer survival in Europe: a 2000–02 period analysis of EUROCARE-4 data | Lancet Oncology, The | 2007 | 819 |
| 50 | Cloning of the T gene required in mesoderm formation in the mouse | Nature | 1990 | 818 |
