| # | Title | Journal | Year | Citations |
|---|
| 1 | A cross-platform toolkit for mass spectrometry and proteomics | Nature Biotechnology | 2012 | 2,794 |
| 2 | A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics | Analytical Chemistry | 2004 | 2,280 |
| 3 | The RIN: an RNA integrity number for assigning integrity values to RNA measurements | BMC Molecular Biology | 2006 | 2,096 |
| 4 | Molecular classification of cutaneous malignant melanoma by gene expression profiling | Nature | 2000 | 1,877 |
| 5 | Targeted capture and massively parallel sequencing of 12 human exomes | Nature | 2009 | 1,801 |
| 6 | lincRNAs act in the circuitry controlling pluripotency and differentiation | Nature | 2011 | 1,749 |
| 7 | The genome sequence of the rice blast fungus Magnaporthe grisea | Nature | 2005 | 1,447 |
| 8 | Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing | Nature Biotechnology | 2009 | 1,267 |
| 9 | PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project | Journal of Thoracic Oncology | 2017 | 1,067 |
| 10 | The DNA-encoded nucleosome organization of a eukaryotic genome | Nature | 2009 | 1,063 |
| 11 | Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells | Nature Biotechnology | 2009 | 985 |
| 12 | Mapping and sequencing of structural variation from eight human genomes | Nature | 2008 | 983 |
| 13 | Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma | Cancer Cell | 2007 | 941 |
| 14 | Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C | Nature Genetics | 2015 | 857 |
| 15 | In-plane heterostructures of graphene and hexagonal boron nitride with controlled domain sizes | Nature Nanotechnology | 2013 | 796 |
| 16 | Towards practical, high-capacity, low-maintenance information storage in synthesized DNA | Nature | 2013 | 787 |
| 17 | 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets | Nature Methods | 2006 | 782 |
| 18 | Image classification for content-based indexing | IEEE Transactions on Image Processing | 2001 | 615 |
| 19 | Diversity of Human Copy Number Variation and Multicopy Genes | Science | 2010 | 609 |
| 20 | Imaging the body with diffuse optical tomography | IEEE Signal Processing Magazine | 2001 | 578 |
| 21 | Ultrathin high-temperature oxidation-resistant coatings of hexagonal boron nitride | Nature Communications | 2013 | 536 |
| 22 | Programmed Death-Ligand 1 Expression and Response to the Anti–Programmed Death 1 Antibody Pembrolizumab in Melanoma | Journal of Clinical Oncology | 2016 | 528 |
| 23 | Amino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry | Analytical Chemistry | 2000 | 505 |
| 24 | Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 489 |
| 25 | Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing | Science | 2009 | 483 |
| 26 | 26 Tbit s−1 line-rate super-channel transmission utilizing all-optical fast Fourier transform processing | Nature Photonics | 2011 | 483 |
| 27 | Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming | Nature Biotechnology | 2009 | 458 |
| 28 | Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project | Nature Biotechnology | 2006 | 440 |
| 29 | Multiplex amplification of large sets of human exons | Nature Methods | 2007 | 392 |
| 30 | ROOT — A C++ framework for petabyte data storage, statistical analysis and visualization | Computer Physics Communications | 2009 | 377 |
| 31 | Clinical Utility of the Combined Positive Score for Programmed Death Ligand-1 Expression and the Approval of Pembrolizumab for Treatment of Gastric Cancer | Archives of Pathology and Laboratory Medicine | 2019 | 377 |
| 32 | InGaN/GaN quantum-well heterostructure light-emitting diodes employing photonic crystal structures | Applied Physics Letters | 2004 | 372 |
| 33 | A Permanent Mesoporous Organic Cage with an Exceptionally High Surface Area | Angewandte Chemie - International Edition | 2014 | 363 |
| 34 | An Interlaboratory Evaluation of Drift Tube Ion Mobility–Mass Spectrometry Collision Cross Section Measurements | Analytical Chemistry | 2017 | 361 |
| 35 | Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers | Nature | 2007 | 355 |
| 36 | Conformational Ordering of Biomolecules in the Gas Phase: Nitrogen Collision Cross Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer | Analytical Chemistry | 2014 | 349 |
| 37 | Interaction Transcriptome Analysis Identifies Magnaporthe oryzae BAS1-4 as Biotrophy-Associated Secreted Proteins in Rice Blast Disease | Plant Cell | 2009 | 346 |
| 38 | Developmental programming of CpG island methylation profiles in the human genome | Nature Structural and Molecular Biology | 2009 | 345 |
| 39 | Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 336 |
| 40 | Bio-Microarray Fabrication Techniques—A Review | Critical Reviews in Biotechnology | 2006 | 334 |
| 41 | An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: Sensitivity and specificity analysis | Proteomics | 2005 | 332 |
| 42 | A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility | Cell | 2013 | 332 |
| 43 | Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome | Nature Genetics | 2015 | 330 |
| 44 | The Fine-Scale and Complex Architecture of Human Copy-Number Variation | American Journal of Human Genetics | 2008 | 315 |
| 45 | Recommendations for reporting ion mobility Mass Spectrometry measurements | Mass Spectrometry Reviews | 2019 | 315 |
| 46 | Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates | Chemistry and Biology | 2010 | 313 |
| 47 | Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain | Journal of Biological Chemistry | 2001 | 297 |
| 48 | Identification of Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs) in Natural Waters Using Accurate Mass Time-of-Flight Mass Spectrometry (TOFMS) | Environmental Science & Technology | 2015 | 288 |
| 49 | Analysis and design of broad-band single-layer rectangular u-slot microstrip patch antennas | IEEE Transactions on Antennas and Propagation | 2003 | 286 |
| 50 | Internal quantum efficiency of highly-efficient InxGa1−xN-based near-ultraviolet light-emitting diodes | Applied Physics Letters | 2003 | 275 |
