| # | Title | Journal | Year | Citations |
|---|
| 1 | Complete sequencing and characterization of 21,243 full-length human cDNAs | Nature Genetics | 2004 | 796 |
| 2 | OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice | PLoS Medicine | 2006 | 631 |
| 3 | The power of genetic diversity in genome-wide association studies of lipids | Nature | 2021 | 353 |
| 4 | Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195 | Diabetologia | 1999 | 214 |
| 5 | Epstein‐Barr Virus (EBV) Load and Cytokine Gene Expression in Activated T Cells of Chronic Active EBV Infection | Journal of Infectious Diseases | 2001 | 186 |
| 6 | Cannabidivarin is anticonvulsant in mouse and rat | British Journal of Pharmacology | 2012 | 139 |
| 7 | Tolvaptan inhibits ERK-dependent cell proliferation, Cl−secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin | American Journal of Physiology - Renal Physiology | 2011 | 131 |
| 8 | Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double‐blind, placebo‐controlled trial | Hepatology Research | 2014 | 128 |
| 9 | Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits. | Journal of Biological Chemistry | 1990 | 120 |
| 10 | mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms | American Journal of Physiology - Cell Physiology | 2009 | 112 |
| 11 | Non–HDL Cholesterol Shows Improved Accuracy for Cardiovascular Risk Score Classification Compared to Direct or Calculated LDL Cholesterol in a Dyslipidemic Population | Clinical Chemistry | 2011 | 98 |
| 12 | Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis | Molecular Psychiatry | 2016 | 95 |
| 13 | Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors | Cancer Research and Treatment | 2015 | 93 |
| 14 | DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression | Laboratory Investigation | 2011 | 92 |
| 15 | Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a saliva protein from a malaria vector mosquito | Blood | 2008 | 88 |
| 16 | Acrosome Reaction and Lysins | Blood | 1967 | 79 |
| 17 | 2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide (OPB-9195) treatment inhibits the development of intimal thickening after balloon injury of rat carotid artery: role of glycoxidation and lipoxidation reactions in vascular tissue damage | FEBS Letters | 1999 | 76 |
| 18 | Dose‐finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: A randomized, double‐blind, placebo‐controlled trial | Hepatology Research | 2014 | 67 |
| 19 | Aripiprazole, a novel antipsychotic agent: Dopamine D2 receptor partial agonist | Journal of Medical Investigation | 2005 | 64 |
| 20 | NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility | Science | 2020 | 63 |
| 21 | Phase 1 and pharmacological trial of OPB‐31121, a signal transducer and activator of transcription‐3 inhibitor, in patients with advanced hepatocellular carcinoma | Hepatology Research | 2015 | 61 |
| 22 | Selection of ganglioside GM1-binding peptides by using a phage library | FEBS Letters | 1999 | 59 |
| 23 | Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens | Arthritis Research | 2005 | 58 |
| 24 | Distinct Osteoclast Precursors in the Bone Marrow and Extramedullary Organs Characterized by Responsiveness to Toll-Like Receptor Ligands and TNF-α | Journal of Immunology | 2003 | 53 |
| 25 | Potential pathophysiological role of d-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain | Journal of Neural Transmission | 2009 | 46 |
| 26 | Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905 | Journal of Antibiotics | 2010 | 46 |
| 27 | Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats | Brain Research | 1999 | 45 |
| 28 | MHC-dependent shaping of the inhibitory Ly49 receptor repertoire on NK cells: evidence for a regulated sequential model | European Journal of Immunology | 2001 | 40 |
| 29 | Differential effects on D2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary | Molecular Brain Research | 1998 | 39 |
| 30 | Decrease in triglyceride accumulation in tissues by restricted diet and improvement of diabetes in otsuka long-evans tokushima fatty rats, a non—insulin-dependent diabetes model | Metabolism: Clinical and Experimental | 2000 | 39 |
| 31 | A Novel Mechanism of Growth Phase-dependent Tolerance to Isoniazid in Mycobacteria | Journal of Biological Chemistry | 2012 | 39 |
| 32 | Shear stress down-regulates gene transcription and production of adrenomedullin in human aortic endothelial cells | Journal of Biological Chemistry | 1998 | 32 |
| 33 | Quantitative Monitoring of Circulating Epstein-Barr Virus DNA for Predicting the Development of Posttransplantation Lymphoproliferative Disease | International Journal of Hematology | 2001 | 30 |
| 34 | DNA Augments Antigenicity of Mycobacterial DNA-Binding Protein 1 and Confers Protection againstMycobacterium tuberculosisInfection in Mice | Journal of Immunology | 2005 | 26 |
| 35 | Changes in weight and weight-related quality of life in a multicentre, randomized trial of aripiprazole versus standard of care | European Psychiatry | 2008 | 26 |
| 36 | Difference in Bias Approach for Commutability Assessment: Application to Frozen Pools of Human Serum Measured by 8 Direct Methods for HDL and LDL Cholesterol | Clinical Chemistry | 2015 | 26 |
| 37 | Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its invitro biological activity: Molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF | Biochemical and Biophysical Research Communications | 1989 | 25 |
| 38 | Cognitive dysfunction and histological findings in rats with chronic-stage contusion and diffuse axonal injury | Brain Research Protocols | 1998 | 25 |
| 39 | Enhanced renal Na+reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2012 | 25 |
| 40 | Acquisition of cell adhesion and induction of focal adhesion kinase of human colon cancer Colo 201 cells by retinoic acid-induced differentiation | Differentiation | 1998 | 24 |
| 41 | Japan PGx Data Science Consortium Database: SNPs and HLA genotype data from 2994 Japanese healthy individuals for pharmacogenomics studies | Journal of Human Genetics | 2015 | 24 |
| 42 | High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages | Scientific Reports | 2018 | 23 |
| 43 | A role for local calcium gradients upon hypoxic injury in human umbilical vein endothelial cells (HUVEC) | Cell Calcium | 1998 | 21 |
| 44 | Effect of amino acids and glucose on exercise-induced gut and skeletal muscle proteolysis in dogs | Metabolism: Clinical and Experimental | 1999 | 21 |
| 45 | Defective glycosylation of α-dystroglycan contributes to podocyte flattening | Kidney International | 2011 | 21 |
| 46 | New rat model induced by anti‐glomerular basement membrane antibody shows severe glomerular adhesion in early stage and quickly progresses to end‐stage renal failure | Pathology International | 2008 | 19 |
| 47 | Modulation of an ultraviolet mutational hotspot in a shuttle vector in Xeroderma cells | Nucleic Acids Research | 1991 | 18 |
| 48 | Effects of cilostazol, an antiplatelet agent, on axonal regeneration following nerve injury in diabetic rats | European Journal of Pharmacology | 1998 | 18 |
| 49 | A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene | American Journal of Physiology - Endocrinology and Metabolism | 1998 | 18 |
| 50 | Induction of micronucleated reticulocytes by potassium bromate and potassium chromate in CD-1 male mice | Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental Or Occupational Exposure | 1992 | 17 |
