# | Title | Journal | Year | Citations |
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1 | Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study | Arthritis and Rheumatism | 2005 | 656 |
2 | Prediction of Pulmonary Complications and Long‐Term Survival in Systemic Sclerosis | Arthritis and Rheumatology | 2014 | 354 |
3 | Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study | Lancet Respiratory Medicine,the | 2017 | 201 |
4 | Survival in systemic sclerosis-associated pulmonary arterial hypertension in the modern management era | Annals of the Rheumatic Diseases | 2013 | 128 |
5 | Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study | Arthritis and Rheumatology | 2016 | 122 |
6 | Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study | Lancet Rheumatology, The | 2020 | 117 |
7 | Randomized, prospective, placebo‐controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis | Arthritis and Rheumatism | 2010 | 111 |
8 | Prognostic implications of serial risk score assessments in patients with pulmonary arterial hypertension: A Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) analysis | Journal of Heart and Lung Transplantation | 2015 | 111 |
9 | Three- Versus Two-Drug Therapy for Patients With Newly Diagnosed Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2021 | 90 |
10 | Treatment of patients with pulmonary arterial hypertension at the time of death or deterioration to functional class IV: Insights from the REVEAL Registry | Journal of Heart and Lung Transplantation | 2013 | 86 |
11 | Starving the Malaria Parasite: Inhibitors Active against the Aspartic Proteases Plasmepsins I, II, and IV | Angewandte Chemie - International Edition | 2006 | 84 |
12 | Evaluation of Macitentan in Patients With Eisenmenger Syndrome | Circulation | 2019 | 83 |
13 | Validation of two predictive models for survival in pulmonary arterial hypertension | European Respiratory Journal | 2015 | 82 |
14 | Acute Heart Failure in the Elderly: Differences in Clinical Characteristics, Outcomes, and Prognostic Factors in the VERITAS Study | Journal of Cardiac Failure | 2015 | 65 |
15 | Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene | Behavioural Brain Research | 2003 | 59 |
16 | Acute Hemodynamic Effects of Single‐Dose Sildenafil When Added to Established Bosentan Therapy in Patients With Pulmonary Arterial Hypertension: Results of the COMPASS‐1 Study | Journal of Clinical Pharmacology | 2009 | 57 |
17 | Early Worsening Heart Failure in Patients Admitted for Acute Heart Failure: Time Course, Hemodynamic Predictors, and Outcome | Journal of Cardiac Failure | 2009 | 56 |
18 | The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice | Diabetologia | 2012 | 51 |
19 | Cardiac Troponin I and T as Prognostic Markers in Cats with Hypertrophic Cardiomyopathy | Journal of Veterinary Internal Medicine | 2014 | 43 |
20 | Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials | Lancet Infectious Diseases, The | 2019 | 41 |
21 | A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy | Molecular Cancer | 2010 | 40 |
22 | Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90 | Journal of Medicinal Chemistry | 2014 | 34 |
23 | Clinical characteristics and predictors of gangrene in patients with systemic sclerosis and digital ulcers in the Digital Ulcer Outcome Registry: a prospective, observational cohort | Annals of the Rheumatic Diseases | 2016 | 34 |
24 | Health State Utilities Associated with Glucose Monitoring Devices | Value in Health | 2017 | 28 |
25 | Effects of Miglustat on Stabilization of Neurological Disorder in Niemann–Pick Disease Type C | Journal of Child Neurology | 2013 | 27 |
26 | A recessive ataxia diagnosis algorithm for the next generation sequencing era | Annals of Neurology | 2017 | 27 |
27 | Long‐Term Outcomes in Patients With Connective Tissue Disease–Associated Pulmonary Arterial Hypertension in the Modern Treatment Era: Meta‐Analyses of Randomized, Controlled Trials and Observational Registries | Arthritis and Rheumatology | 2021 | 26 |
28 | A new model to evaluate the long-term cost effectiveness of orphan and highly specialised drugs following listing on the Australian Pharmaceutical Benefits Scheme: the Bosentan Patient Registry | Journal of Medical Economics | 2008 | 21 |
29 | Growth in children with pulmonary arterial hypertension: a longitudinal retrospective multiregistry study | Lancet Respiratory Medicine,the | 2016 | 20 |
30 | Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort | Annals of the Rheumatic Diseases | 2018 | 20 |
31 | Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study | Rheumatology | 2021 | 20 |
32 | Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay | Acta Pharmacologica Sinica | 2008 | 19 |
33 | Endothelin research and the discovery of macitentan for the treatment of pulmonary arterial hypertension | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2016 | 19 |
34 | Pharmacokinetic/Pharmacodynamic Modeling of Renin Biomarkers in Subjects Treated With the Renin Inhibitor Aliskiren | Clinical Pharmacology and Therapeutics | 2008 | 18 |
35 | Niemann–Pick type C: focus on the adolescent/adult onset form | International Journal of Neuroscience | 2016 | 18 |
36 | Prediction of Long‐Term Outcome by Measurement of Serum Concentration of Cardiac Troponins in Critically Ill Dogs with Systemic Inflammation | Journal of Veterinary Internal Medicine | 2014 | 17 |
37 | The long-term tolerability and efficacy of armodafinil in patients with excessive sleepiness associated with treated obstructive sleep apnea, shift work disorder, or narcolepsy: an open-label extension study | Journal of Clinical Sleep Medicine | 2010 | 17 |
38 | Vertebral fractures in Gaucher disease type I: data from the French “Observatoire” on Gaucher disease (FROG) | Osteoporosis International | 2011 | 16 |
39 | Simultaneous pulmonary and systemic blood pressure and ECG Interval measurement in conscious, freely moving rats | Journal of the American Association for Laboratory Animal Science | 2012 | 15 |
40 | Endothelin Mediates the Altered Renal Hemodynamics Associated with Experimental Congestive Heart Failure | Journal of Cardiovascular Pharmacology | 2001 | 12 |
41 | Tezosentan, a novel endothelin receptor antagonist, markedly reduces rat hepatic ischemia and reperfusion injury in three different models | Liver Transplantation | 2008 | 10 |
42 | Development of macitentan for the treatment of pulmonary arterial hypertension | Annals of the New York Academy of Sciences | 2015 | 7 |
43 | Risks associated with antiretroviral treatment for human immunodeficiency virus (HIV): qualitative analysis of social media data and health state utility valuation | Quality of Life Research | 2017 | 7 |
44 | Clazosentan for patients with subarachnoid haemorrhage: lessons learned – Authors' reply | Lancet Neurology, The | 2011 | 6 |
45 | Identification of a pulmonary arterial hypertension (PAH) patient cohort and study of its burden of illness in Programme de Médicalisation des Systèmes d'information (PMSI) | International Journal of Cardiology | 2020 | 6 |
46 | The Infiltration of Terrorist Organizations Into the Pharmaceutical Industry: Hezbollah as a Case Study | Studies in Conflict and Terrorism | 2013 | 5 |
47 | Pulmonary hypertension: a correct diagnosis for a suitable therapy in scleroderma patients | Clinical and Experimental Rheumatology | 2015 | 5 |
48 | Bosentan therapy for pulmonary arterial hypertension: a case report of a 16-month-old boy | Current Medical Research and Opinion | 2007 | 3 |
49 | Monocrotaline‐Induced Pulmonary Hypertension in Wistar Rats | Current Protocols in Pharmacology | 2009 | 3 |
50 | The PROSPECT Registry of Pulmonary Arterial Hypertension (PAH): Description of Patients Who Transitioned From Inhaled Prostacyclin to Intravenous Epoprostenol | Journal of Heart and Lung Transplantation | 2014 | 1 |