| # | Title | Journal | Year | Citations |
|---|
| 1 | KEGG: Kyoto Encyclopedia of Genes and Genomes | Nucleic Acids Research | 2000 | 25,375 |
| 2 | Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors | Cell | 2006 | 22,649 |
| 3 | Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors | Cell | 2007 | 17,969 |
| 4 | KEGG: Kyoto Encyclopedia of Genes and Genomes | Nucleic Acids Research | 1999 | 13,711 |
| 5 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform | Nucleic Acids Research | 2002 | 12,537 |
| 6 | Functional Porous Coordination Polymers | Angewandte Chemie - International Edition | 2004 | 10,106 |
| 7 | First principles phonon calculations in materials science | Scripta Materialia | 2015 | 7,324 |
| 8 | Control of Regulatory T Cell Development by the Transcription Factor Foxp3 | Science | 2003 | 7,292 |
| 9 | KEGG: new perspectives on genomes, pathways, diseases and drugs | Nucleic Acids Research | 2017 | 6,666 |
| 10 | KEGG for linking genomes to life and the environment | Nucleic Acids Research | 2007 | 5,451 |
| 11 | KEGG as a reference resource for gene and protein annotation | Nucleic Acids Research | 2016 | 5,435 |
| 12 | CP-Violation in the Renormalizable Theory of Weak Interaction | Progress of Theoretical Physics | 1973 | 5,381 |
| 13 | Research Development on Sodium-Ion Batteries | Chemical Reviews | 2014 | 4,970 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 15 | CaCl2-typeSiO2at high pressures">First-principles calculations of the ferroelastic transition between rutile-type andCaCl2-typeSiO2at high pressures | Physical Review B | 2008 | 4,498 |
| 16 | Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation | Journal of Experimental Medicine | 2000 | 4,394 |
| 17 | Regulatory T Cells and Immune Tolerance | Cell | 2008 | 4,269 |
| 18 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 19 | MAFFT version 5: improvement in accuracy of multiple sequence alignment | Nucleic Acids Research | 2005 | 4,184 |
| 20 | KEGG for integration and interpretation of large-scale molecular data sets | Nucleic Acids Research | 2012 | 4,174 |
| 21 | The KEGG resource for deciphering the genome | Nucleic Acids Research | 2004 | 4,093 |
| 22 | Generation of germline-competent induced pluripotent stem cells | Nature | 2007 | 4,019 |
| 23 | Transport, Collective Motion, and Brownian Motion | Progress of Theoretical Physics | 1965 | 3,925 |
| 24 | KAAS: an automatic genome annotation and pathway reconstruction server | Nucleic Acids Research | 2007 | 3,517 |
| 25 | Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. | Journal of Experimental Medicine | 1992 | 3,473 |
| 26 | Solutions able to reproducein vivo surface-structure changes in bioactive glass-ceramic A-W3 | Journal of Biomedical Materials Research Part B | 1990 | 3,425 |
| 27 | XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor | Cell | 2001 | 3,396 |
| 28 | Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses | Nature | 2006 | 3,292 |
| 29 | Metal-Catalyzed Living Radical Polymerization | Chemical Reviews | 2001 | 3,247 |
| 30 | Cadherin cell adhesion receptors as a morphogenetic regulator | Science | 1991 | 3,164 |
| 31 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 32 | NaturallyArisingCD4+RegulatoryT Cells forImmunologicSelf-Tolerance andNegativeControl ofImmuneResponses | Annual Review of Immunology | 2004 | 3,091 |
| 33 | Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme | Cell | 2000 | 3,089 |
| 34 | Metal–Organic Frameworks (MOFs) | Chemical Society Reviews | 2014 | 2,973 |
| 35 | BlastKOALA and GhostKOALA: KEGG Tools for Functional Characterization of Genome and Metagenome Sequences | Journal of Molecular Biology | 2016 | 2,872 |
| 36 | Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension | Nature | 1997 | 2,733 |
| 37 | Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 | Journal of the American College of Cardiology | 2017 | 2,705 |
| 38 | From genomics to chemical genomics: new developments in KEGG | Nucleic Acids Research | 2006 | 2,662 |
| 39 | Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts | Nature Biotechnology | 2008 | 2,583 |
| 40 | Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 2,563 |
| 41 | Cloning and expression of a cDNA encoding an endothelin receptor | Nature | 1990 | 2,554 |
| 42 | A pharmacokinetic analysis program (multi) for microcomputer. | Journal of Pharmacobio-dynamics | 1981 | 2,533 |
| 43 | PD-L2 is a second ligand for PD-1 and inhibits T cell activation | Nature Immunology | 2001 | 2,504 |
| 44 | Molecular diversity of glutamate receptors and implications for brain function | Science | 1992 | 2,494 |
| 45 | High-Q photonic nanocavity in a two-dimensional photonic crystal | Nature | 2003 | 2,493 |
| 46 | CTLA-4 Control over Foxp3 + Regulatory T Cell Function | Science | 2008 | 2,490 |
| 47 | Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis | Nature Cell Biology | 2000 | 2,487 |
| 48 | Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. | EMBO Journal | 1992 | 2,456 |
| 49 | Shifting the limits in wheat research and breeding using a fully annotated reference genome | Science | 2018 | 2,424 |
| 50 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self | Nature Immunology | 2005 | 2,417 |
