| # | Title | Journal | Year | Citations |
|---|
| 1 | Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? | Environmental Health Perspectives | 2012 | 1,033 |
| 2 | Net Health Benefits | Medical Decision Making | 1998 | 809 |
| 3 | Beyond Thermodynamic Acidity: A Perspective on the Complex-Induced Proximity Effect (CIPE) in Deprotonation Reactions | Angewandte Chemie - International Edition | 2004 | 662 |
| 4 | Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols | JAMA - Journal of the American Medical Association | 2018 | 507 |
| 5 | Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations | Pain | 2016 | 270 |
| 6 | Non-cardiac chest pain: prevalence, risk factors, impact and consulting - a population-based study | Alimentary Pharmacology and Therapeutics | 2003 | 227 |
| 7 | CO2 Laser Inhibition of Artificial Caries-like Lesion Progression in Dental Enamel | Journal of Dental Research | 1998 | 213 |
| 8 | The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes | Kidney International | 2005 | 201 |
| 9 | Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study | Brain | 2020 | 201 |
| 10 | Drug precipitation inhibitors in supersaturable formulations | International Journal of Pharmaceutics | 2013 | 177 |
| 11 | Twenty‐five years of confirmatory adaptive designs: opportunities and pitfalls | Statistics in Medicine | 2016 | 166 |
| 12 | CLSI-Derived Hematology and Biochemistry Reference Intervals for Healthy Adults in Eastern and Southern Africa | PLoS ONE | 2009 | 139 |
| 13 | Quantitative analysis of cell composition and purity of human pancreatic islet preparations | Laboratory Investigation | 2010 | 137 |
| 14 | Cytokines and feeding | International Journal of Obesity | 2001 | 130 |
| 15 | Meta-analysis as Evidence | JAMA - Journal of the American Medical Association | 2014 | 124 |
| 16 | Erythropoietin Concentrations in Cerebrospinal Fluid of Nonhuman Primates and Fetal Sheep following High-Dose Recombinant Erythropoietin | Neonatology | 2004 | 119 |
| 17 | Dominant–submissive behavior as models of mania and depression | Neuroscience and Biobehavioral Reviews | 2005 | 116 |
| 18 | Research design considerations for chronic pain prevention clinical trials | Pain | 2015 | 115 |
| 19 | Tpeak-Tend Interval as an Index of Global Dispersion of Ventricular Repolarization: Evaluations Using Monophasic Action Potential Mapping of the Epi- and Endocardium in Swine | Journal of Interventional Cardiac Electrophysiology | 2005 | 113 |
| 20 | Innervation Patterns May Limit Response to Endovascular Renal Denervation | Journal of the American College of Cardiology | 2014 | 110 |
| 21 | Chronic Abdominal Pain and Depressive Symptoms: Analysis of the National Longitudinal Study of Adolescent Health | Clinical Gastroenterology and Hepatology | 2008 | 106 |
| 22 | STaRT-RWE: structured template for planning and reporting on the implementation of real world evidence studies | BMJ, The | 2021 | 101 |
| 23 | Intestinal uptake and biodistribution of novel polymeric micelles after oral administration | Journal of Controlled Release | 2006 | 96 |
| 24 | Assessing the Financial Value of Patient Engagement: A Quantitative Approach from CTTI’s Patient Groups and Clinical Trials Project | Therapeutic Innovation and Regulatory Science | 2018 | 96 |
| 25 | Thin microelectrodes reduce GFAP expression in the implant site in rodent somatosensory cortex | Journal of Neural Engineering | 2007 | 93 |
| 26 | A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development | Regulatory Toxicology and Pharmacology | 2008 | 89 |
| 27 | The relationship between seizure frequency, seizure type and quality of life: Findings from three European countries | Epilepsy Research | 1998 | 88 |
| 28 | A calcar collar is protective against early periprosthetic femoral fracture around cementless femoral components in primary total hip arthroplasty | Bone and Joint Journal | 2019 | 83 |
| 29 | Age-Specific Differences in Oncogenic Pathway Deregulation Seen in Human Breast Tumors | PLoS ONE | 2008 | 81 |
| 30 | Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex | Neuroscience Letters | 2002 | 80 |
| 31 | Use of Tissue Cross-reactivity Studies in the Development of Antibody-based Biopharmaceuticals | Toxicologic Pathology | 2010 | 77 |
| 32 | Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone | Journal of Controlled Release | 2005 | 76 |
| 33 | Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review | Journal of Pharmacy and Pharmacology | 2019 | 76 |
| 34 | PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats | Journal of Psychopharmacology | 2012 | 75 |
| 35 | Food for thought: formulating away the food effect – a PEARRL review | Journal of Pharmacy and Pharmacology | 2019 | 75 |
| 36 | Quantifying the Pathophysiological Timeline of Alzheimer's Disease | Journal of Alzheimer's Disease | 2011 | 70 |
| 37 | Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism | Brain Research | 2009 | 66 |
| 38 | Evaluating the clinical and economic burden of healthcare-associated infections during hospitalization for surgery in France | Epidemiology and Infection | 2013 | 65 |
| 39 | SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials | BMJ Open | 2021 | 65 |
| 40 | Robustness of iCIEF methodology for the analysis of monoclonal antibodies: An interlaboratory study | Journal of Separation Science | 2012 | 63 |
| 41 | Comparison of In Vivo Tissue Temperature Profile and Lesion Geometry for Radiofrequency Ablation With High Power–Short Duration and Moderate Power–Moderate Duration: Effects of Thermal Latency and Contact Force on Lesion Formation | Circulation: Arrhythmia and Electrophysiology | 2021 | 63 |
| 42 | Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element | Biochemical Journal | 2001 | 59 |
| 43 | Galactosylated cellulosic sponge for multi-well drug safety testing | Biomaterials | 2011 | 59 |
| 44 | The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: A new class of Aurora-A kinase inhibitors | Bioorganic and Medicinal Chemistry Letters | 2006 | 58 |
| 45 | Introduction of a process mass intensity metric for biologics | New Biotechnology | 2019 | 57 |
| 46 | Characterizing the effects of inorganic acid and alkaline shock on theStaphylococcus aureustranscriptome and messenger RNA turnover | FEMS Immunology and Medical Microbiology | 2010 | 56 |
| 47 | An Evaluation of the Efficacy and Tolerability of Oral Tramadol Hydrochloride Tablets for the Treatment of Postsurgical Pain in Children | Anesthesia and Analgesia | 2002 | 52 |
| 48 | Oligodeoxyribonucleotide probe accessibility on a three-dimensional DNA microarray surface and the effect of hybridization time on the accuracy of expression ratios | BMC Biotechnology | 2003 | 52 |
| 49 | Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review | Journal of Pharmacy and Pharmacology | 2019 | 52 |
| 50 | Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor | Arthritis Research | 2004 | 51 |
