| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 2 | Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic | Annals of Oncology | 2019 | 1,742 |
| 3 | Renal cell carcinoma | Nature Reviews Disease Primers | 2017 | 1,727 |
| 4 | Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis | Science | 2015 | 924 |
| 5 | Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion | Nature | 2020 | 684 |
| 6 | Self-organization of the human embryo in the absence of maternal tissues | Nature Cell Biology | 2016 | 516 |
| 7 | Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination | Lancet, The | 2021 | 490 |
| 8 | SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects | Nature Structural and Molecular Biology | 2020 | 471 |
| 9 | Resolving genetic heterogeneity in cancer | Nature Reviews Genetics | 2019 | 443 |
| 10 | A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome | Nature Reviews Neuroscience | 2015 | 404 |
| 11 | Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal | Cell | 2018 | 398 |
| 12 | Maintaining cell identity: PRC2-mediated regulation of transcription and cancer | Nature Reviews Cancer | 2016 | 368 |
| 13 | A cell atlas of human thymic development defines T cell repertoire formation | Science | 2020 | 368 |
| 14 | Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study | Lancet Oncology, The | 2019 | 362 |
| 15 | Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2 | Nature Communications | 2016 | 326 |
| 16 | Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes | Cell | 2016 | 320 |
| 17 | Digesting the Expanding Mechanisms of Autophagy | Trends in Cell Biology | 2016 | 303 |
| 18 | Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture | Nature Communications | 2019 | 281 |
| 19 | Guarding the frontiers: the biology of type III interferons | Nature Immunology | 2015 | 279 |
| 20 | Tumor Microenvironment and Differential Responses to Therapy | Cold Spring Harbor Perspectives in Medicine | 2017 | 278 |
| 21 | Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments | Cell | 2016 | 273 |
| 22 | Clinical Implications of Genomic Discoveries in Lung Cancer | New England Journal of Medicine | 2016 | 235 |
| 23 | IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment | EMBO Molecular Medicine | 2016 | 228 |
| 24 | Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates | Molecular Cell | 2017 | 211 |
| 25 | Mechanisms and impact of altered tumour mechanics | Nature Cell Biology | 2018 | 201 |
| 26 | Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function | Molecular Cell | 2017 | 196 |
| 27 | Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection | Nature Immunology | 2020 | 193 |
| 28 | Scientific consensus on the COVID-19 pandemic: we need to act now | Lancet, The | 2020 | 189 |
| 29 | A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation | Cell Reports | 2018 | 188 |
| 30 | 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales | Archives of Virology | 2020 | 184 |
| 31 | COVID-19 and emerging viral infections: The case for interferon lambda | Journal of Experimental Medicine | 2020 | 177 |
| 32 | A high-coverage Neandertal genome from Chagyrskaya Cave | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 176 |
| 33 | Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution | Nature Genetics | 2020 | 168 |
| 34 | TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic | EMBO Journal | 2016 | 166 |
| 35 | Origins of modern human ancestry | Nature | 2021 | 166 |
| 36 | Germinal center B cells recognize antigen through a specialized immune synapse architecture | Nature Immunology | 2016 | 161 |
| 37 | Ancient Genomics of Modern Humans: The First Decade | Annual Review of Genomics and Human Genetics | 2018 | 161 |
| 38 | Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics | Genes and Development | 2017 | 152 |
| 39 | Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer | Science Translational Medicine | 2019 | 150 |
| 40 | Decoding of position in the developing neural tube from antiparallel morphogen gradients | Science | 2017 | 144 |
| 41 | Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis | Cancer Discovery | 2021 | 139 |
| 42 | ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update | Stem Cell Reports | 2021 | 134 |
| 43 | Ancient DNA analysis | Nature Reviews Methods Primers | 2021 | 133 |
| 44 | The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 | Proceedings of the National Academy of Sciences of the United States of America | 2021 | 131 |
| 45 | Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness | Nature Communications | 2016 | 127 |
| 46 | Kidney cancer: The next decade | Journal of Experimental Medicine | 2018 | 125 |
| 47 | An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target | Science Translational Medicine | 2017 | 124 |
| 48 | mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β 1 –induced collagen biosynthesis | Science Signaling | 2019 | 124 |
| 49 | SRF Co-factors Control the Balance between Cell Proliferation and Contractility | Molecular Cell | 2016 | 123 |
| 50 | Optimizing panel-based tumor mutational burden (TMB) measurement | Annals of Oncology | 2019 | 123 |
