| # | Title | Journal | Year | Citations |
|---|
| 1 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 2 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 3 | Observation of Gravitational Waves from a Binary Black Hole Merger | Physical Review Letters | 2016 | 8,753 |
| 4 | Internet of Things (IoT): A vision, architectural elements, and future directions | Future Generation Computer Systems | 2013 | 8,719 |
| 5 | Updated world map of the Köppen-Geiger climate classification | Hydrology and Earth System Sciences | 2007 | 7,579 |
| 6 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma | New England Journal of Medicine | 2015 | 6,773 |
| 7 | Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes | New England Journal of Medicine | 2008 | 6,447 |
| 8 | GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral | Physical Review Letters | 2017 | 6,413 |
| 9 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 10 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase | Gene | 1988 | 6,310 |
| 11 | GCTA: A Tool for Genome-wide Complex Trait Analysis | American Journal of Human Genetics | 2011 | 6,212 |
| 12 | Prediction of Total Genetic Value Using Genome-Wide Dense Marker Maps | Genetics | 2001 | 5,963 |
| 13 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
| 14 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 15 | Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials | Lancet, The | 2016 | 5,331 |
| 16 | The UK Biobank resource with deep phenotyping and genomic data | Nature | 2018 | 5,221 |
| 17 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads | PLoS Computational Biology | 2017 | 5,135 |
| 18 | Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion | Science | 2011 | 4,987 |
| 19 | Neurotoxic reactive astrocytes are induced by activated microglia | Nature | 2017 | 4,977 |
| 20 | Additive manufacturing (3D printing): A review of materials, methods, applications and challenges | Composites Part B: Engineering | 2018 | 4,756 |
| 21 | Species Distribution Models: Ecological Explanation and Prediction Across Space and Time | Annual Review of Ecology, Evolution, and Systematics | 2009 | 4,747 |
| 22 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 23 | Dementia prevention, intervention, and care: 2020 report of the Lancet Commission | Lancet, The | 2020 | 4,658 |
| 24 | A working guide to boosted regression trees | Journal of Animal Ecology | 2008 | 4,623 |
| 25 | Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility | Future Generation Computer Systems | 2009 | 4,520 |
| 26 | Global prevalence of dementia: a Delphi consensus study | Lancet, The | 2005 | 4,496 |
| 27 | A statistical explanation of MaxEnt for ecologists | Diversity and Distributions | 2011 | 4,420 |
| 28 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 29 | Interpenetrating Nets: Ordered, Periodic Entanglement | Angewandte Chemie - International Edition | 1998 | 4,229 |
| 30 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease | Cell | 2017 | 4,081 |
| 31 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 32 | Common SNPs explain a large proportion of the heritability for human height | Nature Genetics | 2010 | 3,888 |
| 33 | Genome sequence of the human malaria parasite Plasmodium falciparum | Nature | 2002 | 3,881 |
| 34 | ILAE Official Report: A practical clinical definition of epilepsy | Epilepsia | 2014 | 3,770 |
| 35 | Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis | Lancet Infectious Diseases, The | 2018 | 3,672 |
| 36 | CloudSim: a toolkit for modeling and simulation of cloud computing environments and evaluation of resource provisioning algorithms | Software - Practice and Experience | 2011 | 3,550 |
| 37 | ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 3,464 |
| 38 | Global Prevalence and Major Risk Factors of Diabetic Retinopathy | Diabetes Care | 2012 | 3,439 |
| 39 | Surface Plasmon Spectroscopy of Nanosized Metal Particles | Langmuir | 1996 | 3,293 |
| 40 | Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) | Lancet, The | 1998 | 3,216 |
| 41 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2020 | 3,177 |
| 42 | Geopolymer technology: the current state of the art | Journal of Materials Science | 2007 | 3,163 |
| 43 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 44 | Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies | American Journal of Human Genetics | 2003 | 3,105 |
| 45 | Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease | New England Journal of Medicine | 2012 | 3,005 |
| 46 | The RCP greenhouse gas concentrations and their extensions from 1765 to 2300 | Climatic Change | 2011 | 2,948 |
| 47 | Neurodegenerative diseases and oxidative stress | Nature Reviews Drug Discovery | 2004 | 2,923 |
| 48 | Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 | Journal of the American College of Cardiology | 2017 | 2,705 |
| 49 | GW151226: Observation of Gravitational Waves from a 22-Solar-Mass Binary Black Hole Coalescence | Physical Review Letters | 2016 | 2,701 |
| 50 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
