# | Title | Journal | Year | Citations |
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1 | Physical growth: National Center for Health Statistics percentiles | American Journal of Clinical Nutrition | 1979 | 2,215 |
2 | Discovering High-Affinity Ligands for Proteins: SAR by NMR | Science | 1996 | 2,045 |
3 | X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death | Nature | 1996 | 1,427 |
4 | Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis | Science | 1997 | 1,394 |
5 | A decade of fragment-based drug design: strategic advances and lessons learned | Nature Reviews Drug Discovery | 2007 | 959 |
6 | Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer | European Journal of Clinical Nutrition | 2002 | 832 |
7 | Ordered accumulation of mutations in HIV protease confers resistance to ritonavir | Nature Medicine | 1996 | 762 |
8 | Tumour-initiating cells: challenges and opportunities for anticancer drug discovery | Nature Reviews Drug Discovery | 2009 | 755 |
9 | Structural Basis for the Inhibition of Caspase-3 by XIAP | Cell | 2001 | 717 |
10 | Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain | Nature | 2000 | 624 |
11 | Estimating Stature from Knee Height for Persons 60 to 90 Years of Age | Journal of the American Geriatrics Society | 1985 | 620 |
12 | Selected Indigestible Oligosaccharides Affect Large Bowel Mass, Cecal and Fecal Short-Chain Fatty Acids, pH and Microflora in Rats , | Journal of Nutrition | 1997 | 597 |
13 | Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease | Science | 1990 | 579 |
14 | Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer | Science | 1990 | 578 |
15 | The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory | Synapse | 1991 | 555 |
16 | Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors | Science | 1995 | 509 |
17 | ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease | Antimicrobial Agents and Chemotherapy | 1998 | 468 |
18 | A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 462 |
19 | Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease | Journal of Biological Chemistry | 1996 | 455 |
20 | Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro | Brain Research | 1990 | 448 |
21 | Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model | Biochemistry | 1989 | 406 |
22 | Solution structure of the antiapoptotic protein bcl-2 | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 404 |
23 | Structure and ligand recognition of the phosphotyrosine binding domain of Shc | Nature | 1995 | 370 |
24 | PRIMARY STRUCTURE AND EVOLUTION OF CYTOCHROME C | Proceedings of the National Academy of Sciences of the United States of America | 1963 | 367 |
25 | NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain | Nature | 1996 | 366 |
26 | Rationale for Bcl‐XL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies | Protein Science | 2000 | 365 |
27 | Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a | Biochemistry | 1989 | 360 |
28 | Privileged Molecules for Protein Binding Identified from NMR-Based Screening | Journal of Medicinal Chemistry | 2000 | 360 |
29 | Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR | Journal of the American Chemical Society | 1997 | 357 |
30 | Discovering novel ligands for macromolecules using X-ray crystallographic screening | Nature Biotechnology | 2000 | 339 |
31 | Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides | Antimicrobial Agents and Chemotherapy | 1988 | 338 |
32 | Growth and Development in Preterm Infants Fed Long-Chain Polyunsaturated Fatty Acids: A Prospective, Randomized Controlled Trial | Pediatrics | 2001 | 337 |
33 | Kringle Domains of Human Angiostatin | Journal of Biological Chemistry | 1996 | 335 |
34 | NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP | Nature | 1999 | 332 |
35 | Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents | Journal of Biological Chemistry | 2003 | 313 |
36 | New Directions in Antibacterial Research | Journal of Medicinal Chemistry | 1996 | 292 |
37 | Expression and possible function of nerve growth factor receptors on Schwann cells | Trends in Neurosciences | 1988 | 289 |
38 | A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments | Journal of Biomolecular NMR | 1993 | 285 |
39 | Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737 | Cancer Research | 2007 | 283 |
40 | Structure-activity relationships of the fluoroquinolones | Antimicrobial Agents and Chemotherapy | 1989 | 278 |
41 | Visual Acuity, Erythrocyte Fatty Acid Composition, and Growth in Term Infants Fed Formulas with Long Chain Polyunsaturated Fatty Acids for One Year | Pediatric Research | 1997 | 270 |
42 | Fragment-Based Drug Design: How Big Is Too Big? | Journal of Medicinal Chemistry | 2006 | 264 |
43 | Modulation of the Immune System by Human Milk and Infant Formula Containing Nucleotides | Pediatrics | 1998 | 255 |
44 | The Resurgence of Breastfeeding in the United States | Pediatrics | 1997 | 248 |
45 | Navigating the kinome | Nature Chemical Biology | 2011 | 241 |
46 | Solution structure of a pleckstrin-homology domain | Nature | 1994 | 240 |
47 | Engineered biosynthesis of a complete macrolactone in a heterologous host | Science | 1994 | 236 |
48 | Prediction of stature from knee height for black and white adults and children with application to mobility-impaired or handicapped persons | Journal of the American Dietetic Association | 1994 | 228 |
49 | Postnatal growth in preterm infants and later health outcomes: a systematic review | Acta Paediatrica, International Journal of Paediatrics | 2015 | 227 |
50 | Kringle 5 of Human Plasminogen Induces Apoptosis of Endothelial and Tumor Cells through Surface-Expressed Glucose-Regulated Protein 78 | Cancer Research | 2005 | 226 |