| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction | New England Journal of Medicine | 2019 | 4,108 |
| 4 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 5 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 7 | Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis | New England Journal of Medicine | 2007 | 2,536 |
| 8 | Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma | Nature | 2012 | 2,129 |
| 9 | Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles | Journal of Extracellular Vesicles | 2014 | 2,110 |
| 10 | Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments | Diabetes Care | 2010 | 1,963 |
| 11 | Standardization of sample collection, isolation and analysis methods in extracellular vesicle research | Journal of Extracellular Vesicles | 2013 | 1,837 |
| 12 | Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles | Cellular and Molecular Life Sciences | 2011 | 1,719 |
| 13 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 14 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Lancet, The | 2019 | 1,625 |
| 15 | Catheter Ablation for Atrial Fibrillation with Heart Failure | New England Journal of Medicine | 2018 | 1,611 |
| 16 | Common variants conferring risk of schizophrenia | Nature | 2009 | 1,572 |
| 17 | Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma | Cancer Cell | 2012 | 1,551 |
| 18 | Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction | New England Journal of Medicine | 2019 | 1,485 |
| 19 | Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial | Lancet, The | 2008 | 1,442 |
| 20 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 21 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 22 | Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders | Journal of Crohn's and Colitis | 2017 | 1,324 |
| 23 | Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial | Lancet, The | 2019 | 1,274 |
| 24 | 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis | Annals of the Rheumatic Diseases | 2017 | 1,220 |
| 25 | Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection | JAMA - Journal of the American Medical Association | 2010 | 1,206 |
| 26 | Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis | British Journal of Psychiatry | 2009 | 1,200 |
| 27 | Suicide prevention strategies revisited: 10-year systematic review | Lancet Psychiatry,the | 2016 | 1,160 |
| 28 | The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosis | European Heart Journal | 2003 | 1,154 |
| 29 | A Calcium Antagonist vs a Non–Calcium Antagonist Hypertension Treatment Strategy for Patients With Coronary Artery Disease | JAMA - Journal of the American Medical Association | 2003 | 1,107 |
| 30 | Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels | Journal of Cell Biology | 2006 | 1,107 |
| 31 | Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation | PLoS Biology | 2012 | 1,064 |
| 32 | Revised nomenclature for avian telencephalon and some related brainstem nuclei | Journal of Comparative Neurology | 2004 | 1,054 |
| 33 | Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper | Journal of Extracellular Vesicles | 2015 | 1,020 |
| 34 | ESPEN Guidelines on Enteral Nutrition: Surgery including Organ Transplantation | Clinical Nutrition | 2006 | 988 |
| 35 | Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol | Pharmacological Reviews | 2006 | 984 |
| 36 | ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents | Journal of Pediatric Gastroenterology and Nutrition | 2014 | 961 |
| 37 | The 90-kDa Molecular Chaperone Family | Journal of Pediatric Gastroenterology and Nutrition | 1998 | 933 |
| 38 | EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research | Nature Methods | 2017 | 886 |
| 39 | Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma | New England Journal of Medicine | 2016 | 861 |
| 40 | Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation | Journal of Medical Internet Research | 2021 | 852 |
| 41 | Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease | New England Journal of Medicine | 2016 | 843 |
| 42 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 836 |
| 43 | Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease | Journal of Crohn's and Colitis | 2014 | 825 |
| 44 | Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients | Oncotarget | 2016 | 821 |
| 45 | Synchronized renal tubular cell death involves ferroptosis | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 801 |
| 46 | Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence | Nature | 2009 | 799 |
| 47 | Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5—a population-based study | Lancet Oncology, The | 2014 | 799 |
| 48 | Strict Blood-Pressure Control and Progression of Renal Failure in Children | New England Journal of Medicine | 2009 | 798 |
| 49 | The burden of inflammatory bowel disease in Europe | Journal of Crohn's and Colitis | 2013 | 781 |
| 50 | Structure and dynamics of molecular networks: A novel paradigm of drug discovery | Journal of Crohn's and Colitis | 2013 | 779 |
