| # | Title | Journal | Year | Citations |
|---|
| 1 | Multiplex Genome Engineering Using CRISPR/Cas Systems | Science | 2013 | 12,725 |
| 2 | The Sequence of the Human Genome | Science | 2001 | 12,623 |
| 3 | Positional cloning of the mouse obese gene and its human homologue | Nature | 1994 | 12,218 |
| 4 | Human malaria parasites in continuous culture | Science | 1976 | 7,213 |
| 5 | Genome sequencing in microfabricated high-density picolitre reactors | Nature | 2005 | 6,669 |
| 6 | The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity | Science | 1998 | 6,408 |
| 7 | Surfing the p53 network | Nature | 2000 | 6,352 |
| 8 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins | Science | 1994 | 5,565 |
| 9 | Protective and Damaging Effects of Stress Mediators | New England Journal of Medicine | 1998 | 5,166 |
| 10 | Stochastic Gene Expression in a Single Cell | Science | 2002 | 4,817 |
| 11 | Effects of stress throughout the lifespan on the brain, behaviour and cognition | Nature Reviews Neuroscience | 2009 | 4,771 |
| 12 | Leptin and the regulation of body weight in mammals | Nature | 1998 | 4,702 |
| 13 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 14 | The Dendritic Cell System and its Role in Immunogenicity | Annual Review of Immunology | 1991 | 4,442 |
| 15 | Weight-reducing effects of the plasma protein encoded by the obese gene | Science | 1995 | 4,369 |
| 16 | Combinatorial microRNA target predictions | Nature Genetics | 2005 | 4,258 |
| 17 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 18 | Complement Factor H Polymorphism in Age-Related Macular Degeneration | Science | 2005 | 4,018 |
| 19 | DNA targeting specificity of RNA-guided Cas9 nucleases | Nature Biotechnology | 2013 | 3,953 |
| 20 | CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein | Science | 1990 | 3,786 |
| 21 | Minimum information about a microarray experiment (MIAME)—toward standards for microarray data | Nature Genetics | 2001 | 3,750 |
| 22 | Silencing of microRNAs in vivo with ‘antagomirs’ | Nature | 2005 | 3,706 |
| 23 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,688 |
| 24 | Identification of a major co-receptor for primary isolates of HIV-1 | Nature | 1996 | 3,667 |
| 25 | STATs and Gene Regulation | Science | 1997 | 3,637 |
| 26 | Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain | Cell | 1999 | 3,557 |
| 27 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 3,486 |
| 28 | Stress, Adaptation, and Disease: Allostasis and Allostatic Load | Annals of the New York Academy of Sciences | 1998 | 3,440 |
| 29 | Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects | Nature Medicine | 1995 | 3,427 |
| 30 | A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing | Cell | 2007 | 3,390 |
| 31 | Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain | Physiological Reviews | 2007 | 3,375 |
| 32 | HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 | Nature | 1996 | 3,257 |
| 33 | Human MicroRNA Targets | PLoS Biology | 2004 | 3,253 |
| 34 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 35 | MicroRNA targets in Drosophila | Genome Biology | 2003 | 3,023 |
| 36 | STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES | Journal of Experimental Medicine | 1944 | 2,969 |
| 37 | The Population Biology of Invasive Species | Annual Review of Ecology, Evolution, and Systematics | 2001 | 2,968 |
| 38 | Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection | Cell | 1996 | 2,964 |
| 39 | In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles | Science | 2002 | 2,961 |
| 40 | TOLEROGENICDENDRITICCELLS | Annual Review of Immunology | 2003 | 2,868 |
| 41 | Limiting Laws and Counterion Condensation in Polyelectrolyte Solutions I. Colligative Properties | Journal of Chemical Physics | 1969 | 2,866 |
| 42 | Comparative Protein Structure Modeling of Genes and Genomes | Annual Review of Biophysics and Biomolecular Structure | 2000 | 2,811 |
| 43 | SH2 domains recognize specific phosphopeptide sequences | Cell | 1993 | 2,735 |
| 44 | Stat3 as an Oncogene | Cell | 1999 | 2,610 |
| 45 | Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP | Cell | 2010 | 2,604 |
| 46 | Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia | Nature | 1987 | 2,558 |
| 47 | Shelterin: the protein complex that shapes and safeguards human telomeres | Genes and Development | 2005 | 2,547 |
| 48 | The concept of allostasis in biology and biomedicine | Hormones and Behavior | 2003 | 2,524 |
| 49 | Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets | Nature Medicine | 2000 | 2,515 |
| 50 | Production of high-titer helper-free retroviruses by transient transfection. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 2,463 |
