| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice | Nature | 2006 | 3,539 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study | Lancet Neurology, The | 2013 | 2,382 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | The application of GIS-based logistic regression for landslide susceptibility mapping in the Kakuda-Yahiko Mountains, Central Japan | Geomorphology | 2005 | 1,388 |
| 7 | Molecular diversity of the NMDA receptor channel | Nature | 1992 | 1,318 |
| 8 | DMY is a Y-specific DM-domain gene required for male development in the medaka fish | Nature | 2002 | 1,311 |
| 9 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 10 | Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA) | Nature Genetics | 1994 | 1,134 |
| 11 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2020 | 1,123 |
| 12 | Theory of Tunneling Spectroscopy ofd-Wave Superconductors | Physical Review Letters | 1995 | 1,094 |
| 13 | Neuronal Subtype-Specific Genes that Control Corticospinal Motor Neuron Development In Vivo | Neuron | 2005 | 1,046 |
| 14 | The medaka draft genome and insights into vertebrate genome evolution | Nature | 2007 | 1,037 |
| 15 | Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity | Science | 2001 | 1,035 |
| 16 | Four-component scattering model for polarimetric SAR image decomposition | IEEE Transactions on Geoscience and Remote Sensing | 2005 | 1,035 |
| 17 | In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses | Nature | 2009 | 1,002 |
| 18 | The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats | Gastroenterology | 2002 | 957 |
| 19 | The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition | Nucleic Acids Research | 2017 | 860 |
| 20 | Genome evolution in the allotetraploid frog Xenopus laevis | Nature | 2016 | 849 |
| 21 | Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit | Nature | 1995 | 835 |
| 22 | Time-dependent local-density approximation in real time | Physical Review B | 1996 | 829 |
| 23 | The main auxin biosynthesis pathway in Arabidopsis | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 827 |
| 24 | Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA | Living Reviews in Relativity | 2018 | 808 |
| 25 | Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene | Nature Genetics | 1994 | 800 |
| 26 | Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs | Nature | 1992 | 791 |
| 27 | Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT | Nature Genetics | 1996 | 773 |
| 28 | Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial | Lancet, The | 2017 | 753 |
| 29 | Non-Abelian Discrete Symmetries in Particle Physics | Progress of Theoretical Physics Supplement | 2010 | 736 |
| 30 | Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction | Cell Metabolism | 2007 | 735 |
| 31 | Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ | Cell | 2001 | 725 |
| 32 | Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts | American Journal of Pathology | 2004 | 702 |
| 33 | Developmental changes in distribution of NMDA receptor channel subunit mRNAs | NeuroReport | 1992 | 690 |
| 34 | Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation | Nature Genetics | 2000 | 685 |
| 35 | Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency | Science | 2006 | 674 |
| 36 | Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice | Cell | 1995 | 661 |
| 37 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2012 | 658 |
| 38 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 652 |
| 39 | Molecular Catalysts for Water Oxidation | Chemical Reviews | 2001 | 641 |
| 40 | Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease | Nature Medicine | 2020 | 641 |
| 41 | p62/SQSTM1 functions as a signaling hub and an autophagy adaptor | FEBS Journal | 2015 | 626 |
| 42 | A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1 | Annals of Neurology | 2002 | 608 |
| 43 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study | Journal of Gastroenterology | 2004 | 603 |
| 44 | Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2019 | 594 |
| 45 | α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy | Neuroscience Letters | 1998 | 581 |
| 46 | Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells | Cell | 2003 | 563 |
| 47 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer | International Journal of Clinical Oncology | 2015 | 548 |
| 48 | Observation of a small atmospheric vμ/ve ratio in Kamiokande | Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | 1992 | 522 |
| 49 | Relationship between periodontal infections and systemic disease | Clinical Microbiology and Infection | 2007 | 519 |
| 50 | The formation and transformation mechanism of calcium carbonate in water | Geochimica Et Cosmochimica Acta | 1987 | 518 |
