| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) | Lancet, The | 2009 | 1,324 |
| 5 | Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure | European Respiratory Journal | 2017 | 1,014 |
| 6 | Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease | Endocrine Reviews | 2009 | 889 |
| 7 | Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells | Molecular and Cellular Biology | 1999 | 804 |
| 8 | Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era | European Heart Journal | 2020 | 716 |
| 9 | Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation | Nature Medicine | 2019 | 602 |
| 10 | The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent | Gastroenterology | 2016 | 506 |
| 11 | Mutations in Col4a1 Cause Perinatal Cerebral Hemorrhage and Porencephaly | Science | 2005 | 474 |
| 12 | Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair | Cell | 2013 | 469 |
| 13 | Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2 | Nature Genetics | 2000 | 462 |
| 14 | Neratinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (ExteNET): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2016 | 444 |
| 15 | Chronic wound infections: the role ofPseudomonas aeruginosaandStaphylococcus aureus | Expert Review of Anti-Infective Therapy | 2015 | 434 |
| 16 | From endothelial dysfunction to atherosclerosis | Autoimmunity Reviews | 2010 | 432 |
| 17 | Formation of stacked ER cisternae by low affinity protein interactions | Journal of Cell Biology | 2003 | 420 |
| 18 | Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved | Journal of Biological Chemistry | 2002 | 413 |
| 19 | Niosomes from 80s to present: The state of the art | Advances in Colloid and Interface Science | 2014 | 371 |
| 20 | MR Imaging Index for Differentiation of Progressive Supranuclear Palsy from Parkinson Disease and the Parkinson Variant of Multiple System Atrophy | Radiology | 2008 | 369 |
| 21 | The role of insulin receptors and IGF-I receptors in cancer and other diseases | Archives of Physiology and Biochemistry | 2008 | 365 |
| 22 | Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans | FASEB Journal | 1999 | 358 |
| 23 | A Newly Identified Role for Superoxide in Inflammatory Pain | Journal of Pharmacology and Experimental Therapeutics | 2004 | 350 |
| 24 | Psychological impact of coronavirus disease 2019 in pregnant women | American Journal of Obstetrics and Gynecology | 2020 | 307 |
| 25 | Clinical Behavior and Outcome of Papillary Thyroid Cancers Smaller than 1.5 cm in Diameter: Study of 299 Cases | Journal of Clinical Endocrinology and Metabolism | 2004 | 299 |
| 26 | High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans | Diabetes | 2001 | 296 |
| 27 | Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice | Neurosurgical Focus | 2010 | 296 |
| 28 | PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells | Human Molecular Genetics | 2014 | 293 |
| 29 | Inhibition of toll‐like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis | Arthritis and Rheumatism | 2007 | 281 |
| 30 | MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo | Circulation Research | 2011 | 280 |
| 31 | Insulin Receptor Isoforms in Physiology and Disease: An Updated View | Endocrine Reviews | 2017 | 270 |
| 32 | MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches | Journal of Hematology and Oncology | 2018 | 268 |
| 33 | Advantages and limits of robot-assisted laparoscopic surgery: preliminary experience | Surgical Endoscopy and Other Interventional Techniques | 2005 | 267 |
| 34 | Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: The CADDementia challenge | NeuroImage | 2015 | 266 |
| 35 | Finite-Time Stability of Linear Time-Varying Systems: Analysis and Controller Design | IEEE Transactions on Automatic Control | 2010 | 254 |
| 36 | Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death | Cells | 2020 | 253 |
| 37 | Erectile Dysfunction as a Predictor of Cardiovascular Events and Death in Diabetic Patients With Angiographically Proven Asymptomatic Coronary Artery Disease | Journal of the American College of Cardiology | 2008 | 251 |
| 38 | A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy | Nature Genetics | 2015 | 245 |
| 39 | Asymmetric Dimethylarginine, L-Arginine, and Endothelial Dysfunction in Essential Hypertension | Journal of the American College of Cardiology | 2005 | 239 |
| 40 | Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity | Environmental Toxicology and Pharmacology | 2013 | 237 |
| 41 | Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib | Oxidative Medicine and Cellular Longevity | 2018 | 237 |
| 42 | Turbiscan Lab® Expert analysis of the stability of ethosomes® and ultradeformable liposomes containing a bilayer fluidizing agent | Colloids and Surfaces B: Biointerfaces | 2009 | 233 |
| 43 | Insulin receptor and cancer | Endocrine-Related Cancer | 2011 | 233 |
| 44 | Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro | Journal of Hepatology | 2012 | 232 |
| 45 | Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial | Lancet Diabetes and Endocrinology,the | 2017 | 231 |
| 46 | The Role of Insulin Receptor Isoforms and Hybrid Insulin/IGF-I Receptors in Human Cancer | Current Pharmaceutical Design | 2007 | 230 |
| 47 | Increased activation of p38 MAPK in COPD | European Respiratory Journal | 2008 | 230 |
| 48 | Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart | Journal of the American College of Cardiology | 2011 | 227 |
| 49 | Determinants of health-related quality of life in pharmacoresistant epilepsy: Results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments | Epilepsia | 2011 | 227 |
| 50 | Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers | International Journal of Surgery | 2016 | 223 |
