| # | Title | Journal | Year | Citations |
|---|
| 1 | Identification of stem cells in small intestine and colon by marker gene Lgr5 | Nature | 2007 | 4,753 |
| 2 | Wnt/β-Catenin Signaling and Disease | Cell | 2012 | 4,658 |
| 3 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities | Cell | 2017 | 2,998 |
| 4 | Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium | Gastroenterology | 2011 | 2,835 |
| 5 | The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes | Journal of Molecular Biology | 2016 | 2,071 |
| 6 | Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts | Nature | 2011 | 2,054 |
| 7 | Cancer stem cells revisited | Nature Medicine | 2017 | 1,895 |
| 8 | Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients | Cell | 2015 | 1,710 |
| 9 | The cancer stem cell: premises, promises and challenges | Nature Medicine | 2011 | 1,691 |
| 10 | Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells | Cell | 2010 | 1,679 |
| 11 | Organoid Models of Human and Mouse Ductal Pancreatic Cancer | Cell | 2015 | 1,584 |
| 12 | Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer | Journal of Experimental Medicine | 2017 | 1,582 |
| 13 | The Human Cell Atlas | ELife | 2017 | 1,547 |
| 14 | Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium | Annual Review of Physiology | 2009 | 1,452 |
| 15 | SARS-CoV-2 productively infects human gut enterocytes | Science | 2020 | 1,347 |
| 16 | A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity | Cell | 2018 | 1,201 |
| 17 | Organoid Cultures Derived from Patients with Advanced Prostate Cancer | Cell | 2014 | 1,184 |
| 18 | Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE | Science | 2010 | 1,124 |
| 19 | An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control | Science | 2014 | 1,060 |
| 20 | ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation | Nature | 2012 | 1,035 |
| 21 | Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas | Science | 2012 | 991 |
| 22 | The Intestinal Crypt, A Prototype Stem Cell Compartment | Cell | 2013 | 929 |
| 23 | Sequential cancer mutations in cultured human intestinal stem cells | Nature | 2015 | 853 |
| 24 | Lgr5 marks cycling, yet long-lived, hair follicle stem cells | Nature Genetics | 2008 | 846 |
| 25 | Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting | Nature Cell Biology | 2010 | 820 |
| 26 | Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors | Nature | 2012 | 791 |
| 27 | Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex | Cell | 2012 | 747 |
| 28 | Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer | Cancer Discovery | 2018 | 676 |
| 29 | Mammalian Mirtron Genes | Molecular Cell | 2007 | 675 |
| 30 | Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish | Developmental Cell | 2015 | 666 |
| 31 | Evolution of microRNA diversity and regulation in animals | Nature Reviews Genetics | 2011 | 645 |
| 32 | Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids | Cell | 2018 | 644 |
| 33 | Self-Renewal and Cancer of the Gut: Two Sides of a Coin | Science | 2005 | 642 |
| 34 | The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension | Cell | 2017 | 636 |
| 35 | The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers | EMBO Journal | 2012 | 634 |
| 36 | Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures | Cell | 2014 | 609 |
| 37 | Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli | Nature | 2020 | 587 |
| 38 | A systematic genome-wide analysis of zebrafish protein-coding gene function | Nature | 2013 | 579 |
| 39 | Disease Modeling in Stem Cell-Derived 3D Organoid Systems | Trends in Molecular Medicine | 2017 | 575 |
| 40 | Reparative inflammation takes charge of tissue regeneration | Nature | 2016 | 570 |
| 41 | Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner | Journal of Cell Biology | 2010 | 569 |
| 42 | Wnt signalling induces maturation of Paneth cells in intestinal crypts | Nature Cell Biology | 2005 | 555 |
| 43 | Risk factors for incident age-related macular degeneration | Ophthalmology | 2004 | 547 |
| 44 | Interrogating open issues in cancer precision medicine with patient-derived xenografts | Nature Reviews Cancer | 2017 | 527 |
| 45 | Development of microRNA therapeutics is coming of age | EMBO Molecular Medicine | 2014 | 526 |
| 46 | Stem-cell-based therapy and lessons from the heart | Nature | 2008 | 523 |
| 47 | HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction | Nature Neuroscience | 2009 | 517 |
| 48 | The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength | Genes and Development | 2014 | 510 |
| 49 | Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids | Cell | 2018 | 505 |
| 50 | Organoid culture systems for prostate epithelial and cancer tissue | Nature Protocols | 2016 | 487 |
