| # | Title | Journal | Year | Citations |
|---|
| 1 | Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol | Lancet, The | 2002 | 4,917 |
| 2 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 3 | Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome | Diabetes Care | 2001 | 4,086 |
| 4 | Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment | Journal of Internal Medicine | 2004 | 4,039 |
| 5 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 6 | Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies | American Journal of Human Genetics | 2003 | 3,105 |
| 7 | Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis | Lancet Neurology, The | 2015 | 2,776 |
| 8 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 9 | Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels | Science | 2007 | 2,623 |
| 10 | Clues to the Pathogenesis of Familial Colorectal Cancer | Science | 1993 | 2,563 |
| 11 | Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases | European Heart Journal | 2013 | 2,436 |
| 12 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 13 | Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials | Lancet, The | 2014 | 1,971 |
| 14 | Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial | Lancet, The | 1999 | 1,938 |
| 15 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,937 |
| 16 | Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor | New England Journal of Medicine | 2001 | 1,926 |
| 17 | Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP | Nature Immunology | 2002 | 1,847 |
| 18 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 19 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 20 | Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial | Lancet, The | 2002 | 1,621 |
| 21 | Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol | Lancet, The | 2002 | 1,520 |
| 22 | EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision | European Journal of Neurology | 2010 | 1,499 |
| 23 | Gut microbiota are related to Parkinson's disease and clinical phenotype | Movement Disorders | 2015 | 1,457 |
| 24 | Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study | Lancet, The | 2005 | 1,447 |
| 25 | Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial | Lancet, The | 1998 | 1,336 |
| 26 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 27 | Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for Breast Cancer | New England Journal of Medicine | 2006 | 1,317 |
| 28 | In vivo amplification of the androgen receptor gene and progression of human prostate cancer | Nature Genetics | 1995 | 1,316 |
| 29 | Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network | Science | 2002 | 1,305 |
| 30 | Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes | Cell | 1999 | 1,271 |
| 31 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 | JAMA Oncology | 2018 | 1,260 |
| 32 | Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer | Gastroenterology | 2000 | 1,259 |
| 33 | Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. | Circulation | 1992 | 1,249 |
| 34 | Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) | Blood | 2007 | 1,243 |
| 35 | Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer | Lancet, The | 1998 | 1,195 |
| 36 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 37 | Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: The Task Force on Acute Heart Failure of the European Society of Cardiology | European Heart Journal | 2005 | 1,114 |
| 38 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 39 | Language-specific phoneme representations revealed by electric and magnetic brain responses | Nature | 1997 | 1,091 |
| 40 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 41 | Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy | JAMA - Journal of the American Medical Association | 2016 | 1,076 |
| 42 | A new definition of neuropathic pain | Pain | 2011 | 1,074 |
| 43 | EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population | European Heart Journal | 2006 | 1,063 |
| 44 | Cancer risk in mutation carriers of DNA-mismatch-repair genes | International Journal of Cancer | 1999 | 1,061 |
| 45 | Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients | Lancet, The | 1998 | 1,054 |
| 46 | Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial | Annals of Oncology | 2014 | 1,022 |
| 47 | Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome†‡ | Human Reproduction | 2018 | 1,015 |
| 48 | Prevalence of aortic valve abnormalities in the elderly: An echocardiographic study of a random population sample | Journal of the American College of Cardiology | 1993 | 1,002 |
| 49 | Risk stratification of patients diagnosed with gastrointestinal stromal tumor | Human Pathology | 2008 | 977 |
| 50 | A Review of Indocyanine Green Fluorescent Imaging in Surgery | International Journal of Biomedical Imaging | 2012 | 972 |
