| # | Title | Journal | Year | Citations |
|---|
| 1 | Global Biodiversity Scenarios for the Year 2100 | Science | 2000 | 7,077 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 5 | How does foreign direct investment affect economic growth? | Journal of International Economics | 1998 | 3,626 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 7 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond | Nature Reviews Molecular Cell Biology | 2012 | 3,080 |
| 8 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales | Ophthalmology | 2003 | 2,664 |
| 9 | The Diagnosis of Polycystic Ovary Syndrome during Adolescence | Hormone Research in Paediatrics | 2015 | 2,130 |
| 10 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study | Lancet Oncology, The | 2010 | 2,093 |
| 11 | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases | Frontiers in Immunology | 2019 | 1,956 |
| 12 | Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis | New England Journal of Medicine | 2006 | 1,677 |
| 13 | Autopoiesis: The organization of living systems, its characterization and a model | BioSystems | 1974 | 1,459 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 15 | Mesenchymal progenitor cells in human umbilical cord blood | British Journal of Haematology | 2000 | 1,371 |
| 16 | Geometry of the 2+1 black hole | Physical Review D | 1993 | 1,336 |
| 17 | Mechanics of the Mammalian Cochlea | Physiological Reviews | 2001 | 1,259 |
| 18 | Chronic Inflammation and Cytokines in the Tumor Microenvironment | Journal of Immunology Research | 2014 | 1,246 |
| 19 | The Impact of Conservation on the Status of the World’s Vertebrates | Science | 2010 | 1,209 |
| 20 | The High‐Z Supernova Search: Measuring Cosmic Deceleration and Global Curvature of the Universe Using Type Ia Supernovae | Astrophysical Journal | 1998 | 1,194 |
| 21 | Present-day South American climate | Palaeogeography, Palaeoclimatology, Palaeoecology | 2009 | 1,156 |
| 22 | Mechanisms, regulation and functions of the unfolded protein response | Nature Reviews Molecular Cell Biology | 2020 | 1,129 |
| 23 | Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe | Astronomical Journal | 2017 | 1,100 |
| 24 | The genome of woodland strawberry (Fragaria vesca) | Nature Genetics | 2011 | 1,091 |
| 25 | Human resources for health: overcoming the crisis | Lancet, The | 2004 | 1,086 |
| 26 | Teacher professional development in Teaching and Teacher Education over ten years | Teaching and Teacher Education | 2011 | 1,071 |
| 27 | Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase | Nature Genetics | 2006 | 1,046 |
| 28 | TRY plant trait database – enhanced coverage and open access | Global Change Biology | 2020 | 1,038 |
| 29 | A terrestrial planet candidate in a temperate orbit around Proxima Centauri | Nature | 2016 | 1,033 |
| 30 | The high-quality draft genome of peach (Prunus persica) identifies unique patterns of genetic diversity, domestication and genome evolution | Nature Genetics | 2013 | 1,031 |
| 31 | Finitely correlated states on quantum spin chains | Communications in Mathematical Physics | 1992 | 1,028 |
| 32 | The Atlantic salmon genome provides insights into rediploidization | Nature | 2016 | 1,021 |
| 33 | Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome†‡ | Human Reproduction | 2018 | 1,015 |
| 34 | Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells | Nature | 2003 | 1,010 |
| 35 | The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients? | Nutrients | 2020 | 997 |
| 36 | Food, livestock production, energy, climate change, and health | Lancet, The | 2007 | 956 |
| 37 | Normalized Mutual Information Feature Selection | IEEE Transactions on Neural Networks | 2009 | 931 |
| 38 | Searching in metric spaces | ACM Computing Surveys | 2001 | 929 |
| 39 | Spectroscopic Target Selection for the Sloan Digital Sky Survey: The Luminous Red Galaxy Sample | Astronomical Journal | 2001 | 856 |
| 40 | Essentiality of copper in humans | American Journal of Clinical Nutrition | 1998 | 852 |
| 41 | Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0 | Nature Protocols | 2019 | 833 |
| 42 | Quantitative characterization of the global electrophilicity power of common diene/dienophile pairs in Diels–Alder reactions | Tetrahedron | 2002 | 832 |
| 43 | Plant diversity in mediterranean-climate regions | Trends in Ecology and Evolution | 1996 | 823 |
| 44 | The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment | Astrophysical Journal, Supplement Series | 2018 | 796 |
| 45 | The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation | ISME Journal | 2013 | 785 |
| 46 | Mesenchymal Stem Cells | Experimental Biology and Medicine | 2001 | 776 |
| 47 | A Microgrid Energy Management System Based on the Rolling Horizon Strategy | IEEE Transactions on Smart Grid | 2013 | 775 |
| 48 | Targeting the unfolded protein response in disease | Nature Reviews Drug Discovery | 2013 | 765 |
| 49 | Practice guidelines for performance of the routine mid‐trimester fetal ultrasound scan | Ultrasound in Obstetrics and Gynecology | 2011 | 760 |
| 50 | Cold Dark Clouds: The Initial Conditions for Star Formation | Annual Review of Astronomy and Astrophysics | 2007 | 757 |
