| # | Title | Journal | Year | Citations |
|---|
| 1 | MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model Space | Systematic Biology | 2012 | 20,458 |
| 2 | The value of the world's ecosystem services and natural capital | Nature | 1997 | 15,321 |
| 3 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation | Journal of Chemical Theory and Computation | 2008 | 13,875 |
| 4 | GROMACS: Fast, flexible, and free | Journal of Computational Chemistry | 2005 | 13,676 |
| 5 | Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen | Journal of Molecular Biology | 2001 | 11,404 |
| 6 | Tissue-based map of the human proteome | Science | 2015 | 10,802 |
| 7 | A safe operating space for humanity | Nature | 2009 | 8,638 |
| 8 | SignalP 4.0: discriminating signal peptides from transmembrane regions | Nature Methods | 2011 | 8,521 |
| 9 | Planetary boundaries: Guiding human development on a changing planet | Science | 2015 | 7,124 |
| 10 | The Chemical Composition of the Sun | Annual Review of Astronomy and Astrophysics | 2009 | 6,648 |
| 11 | Improved Prediction of Signal Peptides: SignalP 3.0 | Journal of Molecular Biology | 2004 | 6,015 |
| 12 | Solutions for a cultivated planet | Nature | 2011 | 5,821 |
| 13 | Catastrophic shifts in ecosystems | Nature | 2001 | 5,656 |
| 14 | Pfam: the protein families database | Nucleic Acids Research | 2014 | 5,425 |
| 15 | Brown Adipose Tissue: Function and Physiological Significance | Physiological Reviews | 2004 | 5,263 |
| 16 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 17 | MultiQC: summarize analysis results for multiple tools and samples in a single report | Bioinformatics | 2016 | 4,633 |
| 18 | Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase | Nature | 2005 | 4,382 |
| 19 | Predicting Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence | Journal of Molecular Biology | 2000 | 4,166 |
| 20 | New tools for automated high-resolution cryo-EM structure determination in RELION-3 | ELife | 2018 | 3,965 |
| 21 | The Pfam protein families database in 2019 | Nucleic Acids Research | 2019 | 3,937 |
| 22 | Planetary Boundaries: Exploring the Safe Operating Space for Humanity | Ecology and Society | 2009 | 3,867 |
| 23 | Plešovice zircon — A new natural reference material for U–Pb and Hf isotopic microanalysis | Chemical Geology | 2008 | 3,858 |
| 24 | ADAPTIVE GOVERNANCE OF SOCIAL-ECOLOGICAL SYSTEMS | Annual Review of Environment and Resources | 2005 | 3,712 |
| 25 | Infrared spectroscopy of proteins | Biochimica Et Biophysica Acta - Bioenergetics | 2007 | 3,547 |
| 26 | The complete genome sequence of the gastric pathogen Helicobacter pylori | Nature | 1997 | 3,405 |
| 27 | SignalP 5.0 improves signal peptide predictions using deep neural networks | Nature Biotechnology | 2019 | 3,317 |
| 28 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2020 | 3,177 |
| 29 | Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver | Biochimica Et Biophysica Acta - General Subjects | 1979 | 3,149 |
| 30 | Climate Change, Human Impacts, and the Resilience of Coral Reefs | Science | 2003 | 3,124 |
| 31 | Pfam: The protein families database in 2021 | Nucleic Acids Research | 2021 | 3,068 |
| 32 | Locating proteins in the cell using TargetP, SignalP and related tools | Nature Protocols | 2007 | 2,940 |
| 33 | Assembly, configuration, and break-up history of Rodinia: A synthesis | Precambrian Research | 2008 | 2,747 |
| 34 | The Lancet Commission on pollution and health | Lancet, The | 2018 | 2,747 |
| 35 | Complexity of Coupled Human and Natural Systems | Science | 2007 | 2,705 |
| 36 | Confronting the coral reef crisis | Nature | 2004 | 2,695 |
| 37 | The Last Glacial Maximum | Science | 2009 | 2,678 |
| 38 | Regime Shifts, Resilience, and Biodiversity in Ecosystem Management | Annual Review of Ecology, Evolution, and Systematics | 2004 | 2,674 |
| 39 | The causes of land-use and land-cover change: moving beyond the myths | Global Environmental Change | 2001 | 2,639 |
| 40 | Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins | Integrated Environmental Assessment and Management | 2011 | 2,567 |
| 41 | An overview of brominated flame retardants in the environment | Chemosphere | 2002 | 2,412 |
| 42 | Status and Ecological Effects of the World’s Largest Carnivores | Science | 2014 | 2,390 |
| 43 | Identification of influential spreaders in complex networks | Nature Physics | 2010 | 2,386 |
| 44 | Climate change and the permafrost carbon feedback | Nature | 2015 | 2,369 |
| 45 | A blueprint for blue carbon: toward an improved understanding of the role of vegetated coastal habitats in sequestering CO2 | Frontiers in Ecology and the Environment | 2011 | 2,354 |
| 46 | AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA | Journal of Cell Biology | 1967 | 2,322 |
| 47 | Effect of aquaculture on world fish supplies | Nature | 2000 | 2,310 |
| 48 | The trajectory of the Anthropocene: The Great Acceleration | Infrastructure Asset Management | 2015 | 2,231 |
| 49 | ENVIRONMENT AND DEVELOPMENT: Sustainability Science | Science | 2001 | 2,169 |
| 50 | Ecosystem services in urban areas | Ecological Economics | 1999 | 2,101 |
