| Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 6.9K |
| Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 3.8K |
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| Defeating Alzheimer's disease and other dementias: a priority for European science and society | Lancet Neurology, The | 2016 | 921 |
| Genome-wide association study identifies 74 loci associated with educational attainment | Nature | 2016 | 850 |
| Integrative approaches for large-scale transcriptome-wide association studies | Nature Genetics | 2016 | 843 |
| Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria | Alzheimer's and Dementia | 2016 | 832 |
| One-pot Synthesis of Metal-Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery | Journal of the American Chemical Society | 2016 | 809 |
| The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013 | Lancet, The | 2016 | 791 |
| Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy | JAMA - Journal of the American Medical Association | 2016 | 780 |
| Suicide prevention strategies revisited: 10-year systematic review | Lancet Psychiatry,the | 2016 | 773 |
| A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score | European Urology | 2016 | 762 |
| Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes | Cell Metabolism | 2016 | 730 |
| REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants | American Journal of Human Genetics | 2016 | 722 |
| Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults | JAMA Internal Medicine | 2016 | 692 |
| Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages | Blood | 2016 | 675 |
| Registers of the Swedish total population and their use in medical research | European Journal of Epidemiology | 2016 | 631 |
| Gene expression elucidates functional impact of polygenic risk for schizophrenia | Nature Neuroscience | 2016 | 622 |
| The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013 | Injury Prevention | 2016 | 611 |
| Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses | Nature Genetics | 2016 | 602 |
| Origin, fate and dynamics of macrophages at central nervous system interfaces | Nature Immunology | 2016 | 572 |
