| HMG-1 as a late mediator of endotoxin lethality in mice | Science | 1999 | 3.4K |
| Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma | New England Journal of Medicine | 1999 | 2.5K |
| Identification of a neural stem cell in the adult mammalian central nervous system | Cell | 1999 | 1.6K |
| Actions of caffeine in the brain with special reference to factors that contribute to its widespread use | Pharmacological Reviews | 1999 | 1.5K |
| Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure | Kidney International | 1999 | 1.2K |
| Notch signalling controls pancreatic cell differentiation | Nature | 1999 | 980 |
| Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 858 |
| Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines | Atherosclerosis | 1999 | 770 |
| Building neural representations of habits | Science | 1999 | 713 |
| Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway | Journal of Biological Chemistry | 1999 | 600 |
| Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis | Multiple Sclerosis Journal | 1999 | 598 |
| Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers | Molecular Psychiatry | 1999 | 586 |
| Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 584 |
| Nephrin is specifically located at the slit diaphragm of glomerular podocytes | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 575 |
| Different modes of expression of AMPA and NMDA receptors in hippocampal synapses | Nature Neuroscience | 1999 | 552 |
| Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness | Nature Genetics | 1999 | 551 |
| Vaginal changes and sexuality in women with a history of cervical cancer | New England Journal of Medicine | 1999 | 536 |
| Angiogenesis inhibited by drinking tea | Nature | 1999 | 510 |
| Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis | Journal of Pathology | 1999 | 500 |
| Association between body mass and adenocarcinoma of the esophagus and gastric cardia | Annals of Internal Medicine | 1999 | 498 |
| Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins | Nucleic Acids Research | 1999 | 488 |
| Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed | Science | 1999 | 454 |
| Novel mutations of the MET proto-oncogene in papillary renal carcinomas | Oncogene | 1999 | 438 |
| Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity | Biochemical Journal | 1999 | 418 |
| Distribution, biochemistry and function of striatal adenosine A2A receptors | Progress in Neurobiology | 1999 | 416 |
