| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Features and development of Coot | Acta Crystallographica Section D: Biological Crystallography | 2010 | 24,068 |
| 2 | A New Depression Scale Designed to be Sensitive to Change | British Journal of Psychiatry | 1979 | 11,935 |
| 3 | Tissue-based map of the human proteome | Science | 2015 | 11,537 |
| 4 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,364 |
| 5 | Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 9,271 |
| 6 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 7,596 |
| 7 | Inflammation, Atherosclerosis, and Coronary Artery Disease | New England Journal of Medicine | 2005 | 7,560 |
| 8 | CHARMM: The biomolecular simulation program | Journal of Computational Chemistry | 2009 | 7,384 |
| 9 | MultiQC: summarize analysis results for multiple tools and samples in a single report | Bioinformatics | 2016 | 5,410 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 11 | Alternative isoform regulation in human tissue transcriptomes | Nature | 2008 | 4,609 |
| 12 | Global prevalence of dementia: a Delphi consensus study | Lancet, The | 2005 | 4,560 |
| 13 | The nuclear RNase III Drosha initiates microRNA processing | Nature | 2003 | 4,519 |
| 14 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,451 |
| 15 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,441 |
| 16 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,397 |
| 17 | Cloning of a novel receptor expressed in rat prostate and ovary. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 4,385 |
| 18 | Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science | Lancet Psychiatry,the | 2020 | 4,332 |
| 19 | HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis | Pediatric Blood and Cancer | 2007 | 4,177 |
| 20 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,158 |
| 21 | Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment | Journal of Internal Medicine | 2004 | 4,132 |
| 22 | ILAE Official Report: A practical clinical definition of epilepsy | Epilepsia | 2014 | 4,054 |
| 23 | Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β | Endocrinology | 1997 | 4,039 |
| 24 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,992 |
| 25 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,915 |
| 26 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,886 |
| 27 | External review and validation of the Swedish national inpatient register | BMC Public Health | 2011 | 3,882 |
| 28 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,872 |
| 29 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,872 |
| 30 | Host-Gut Microbiota Metabolic Interactions | Science | 2012 | 3,839 |
| 31 | Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B | Annals of Neurology | 2004 | 3,835 |
| 32 | Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies | Science Translational Medicine | 2014 | 3,832 |
| 33 | The global prevalence of dementia: A systematic review and metaanalysis | Alzheimer's and Dementia | 2013 | 3,784 |
| 34 | The global prevalence of dementia: A systematic review and metaanalysis | Alzheimer's and Dementia | 2013 | 3,784 |
| 35 | Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β | Endocrinology | 1998 | 3,781 |
| 36 | ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 3,720 |
| 37 | Worldwide Epidemiology of Atrial Fibrillation | Circulation | 2014 | 3,712 |
| 38 | Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland | New England Journal of Medicine | 2000 | 3,618 |
| 39 | International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma | Lancet Oncology, The | 2014 | 3,566 |
| 40 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys | Lancet, The | 2006 | 3,559 |
| 41 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,455 |
| 42 | Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain* | Acta Physiologica Scandinavica | 1971 | 3,395 |
| 43 | Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 | Nature | 1998 | 3,379 |
| 44 | Antibiotic resistance—the need for global solutions | Lancet Infectious Diseases, The | 2013 | 3,343 |
| 45 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,300 |
| 46 | Molecular basis of agonism and antagonism in the oestrogen receptor | Nature | 1997 | 3,160 |
| 47 | Progress and challenges in translating the biology of atherosclerosis | Nature | 2011 | 3,160 |
| 48 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 49 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 50 | International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma | European Respiratory Journal | 2014 | 3,015 |
