| # | Title | Journal | Year | Citations |
|---|
| 1 | Finding the missing heritability of complex diseases | Nature | 2009 | 7,490 |
| 2 | Structure validation by Cα geometry: ϕ,ψ and Cβ deviation | Proteins: Structure, Function and Bioinformatics | 2003 | 4,134 |
| 3 | Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations | Journal of Pain | 2008 | 2,564 |
| 4 | Development of the asthma control test☆A survey for assessing asthma control | Journal of Allergy and Clinical Immunology | 2004 | 2,249 |
| 5 | Type I interferons in infectious disease | Nature Reviews Immunology | 2015 | 1,902 |
| 6 | The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids | Journal of Biological Chemistry | 2003 | 1,866 |
| 7 | Principles of early drug discovery | British Journal of Pharmacology | 2011 | 1,689 |
| 8 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial | Lancet, The | 2004 | 1,435 |
| 9 | Genes mirror geography within Europe | Nature | 2008 | 1,287 |
| 10 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,166 |
| 11 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial | Lancet, The | 2007 | 1,153 |
| 12 | A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ | Nature | 2005 | 1,125 |
| 13 | Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 | Nature | 2018 | 1,115 |
| 14 | The Salmeterol Multicenter Asthma Research Trial | Chest | 2006 | 1,091 |
| 15 | Restless Legs Syndrome Prevalence and Impact | Archives of Internal Medicine | 2005 | 1,046 |
| 16 | Data quality control in genetic case-control association studies | Nature Protocols | 2010 | 1,030 |
| 17 | Swine as Models in Biomedical Research and Toxicology Testing | Veterinary Pathology | 2012 | 1,026 |
| 18 | A selective peroxisome proliferator-activated receptor agonist promotes reverse cholesterol transport | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 1,009 |
| 19 | An analysis of the attrition of drug candidates from four major pharmaceutical companies | Nature Reviews Drug Discovery | 2015 | 996 |
| 20 | Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists | Journal of Allergy and Clinical Immunology | 2006 | 984 |
| 21 | A six-item short-form survey for measuring headache impact: the HIT-6 | Quality of Life Research | 2003 | 954 |
| 22 | Characterisation of COPD heterogeneity in the ECLIPSE cohort | Respiratory Research | 2010 | 952 |
| 23 | HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin | Nature Genetics | 2009 | 950 |
| 24 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits | Nature Genetics | 2009 | 937 |
| 25 | Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial | Lancet, The | 2016 | 929 |
| 26 | Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases | Nature Reviews Drug Discovery | 2019 | 849 |
| 27 | Calcium Absorption Varies within the Reference Range for Serum 25-Hydroxyvitamin D | Journal of the American College of Nutrition | 2003 | 821 |
| 28 | Tracking cancer drugs in living cells by thermal profiling of the proteome | Science | 2014 | 812 |
| 29 | DNA sensing by the cGAS–STING pathway in health and disease | Nature Reviews Genetics | 2019 | 801 |
| 30 | Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants | New England Journal of Medicine | 2010 | 800 |
| 31 | The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism | Endocrine Reviews | 2002 | 798 |
| 32 | Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition | Cell | 2002 | 747 |
| 33 | Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial | Lancet, The | 2008 | 744 |
| 34 | The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity | Science | 2001 | 743 |
| 35 | TRPV3 is a temperature-sensitive vanilloid receptor-like protein | Nature | 2002 | 743 |
| 36 | Development and cross-sectional validation of the Childhood Asthma Control Test | Journal of Allergy and Clinical Immunology | 2007 | 732 |
| 37 | A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses | Breast Cancer Research and Treatment | 2008 | 732 |
| 38 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B | Gastroenterology | 2003 | 724 |
| 39 | Alternatives to antibiotics—a pipeline portfolio review | Lancet Infectious Diseases, The | 2016 | 720 |
| 40 | Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides | Nature Medicine | 1997 | 716 |
| 41 | The promise and peril of chemical probes | Nature Chemical Biology | 2015 | 698 |
| 42 | The Incidence of Congestive Heart Failure in Type 2 Diabetes: An update | Diabetes Care | 2004 | 685 |
| 43 | Type IIA topoisomerase inhibition by a new class of antibacterial agents | Nature | 2010 | 672 |
| 44 | Variants in MTNR1B influence fasting glucose levels | Nature Genetics | 2009 | 662 |
| 45 | Updating and further expanding GSK's solvent sustainability guide | Green Chemistry | 2016 | 656 |
| 46 | Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease | Pharmacogenomics Journal | 2006 | 649 |
| 47 | Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways | Science | 2007 | 643 |
| 48 | Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors | Journal of Biological Chemistry | 2002 | 637 |
| 49 | Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype | PLoS ONE | 2012 | 633 |
| 50 | An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People | Science | 2012 | 626 |
