| Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells | Cancer Research | 2006 | 743 |
| Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease | Pharmacogenomics Journal | 2006 | 563 |
| Polymeric micelles for drug delivery | Current Pharmaceutical Design | 2006 | 415 |
| Development of a pharmacokinetic/pharmacodynamic model for carvedilol to predict beta1-blockade in patients with congestive heart failure | American Journal of Cardiology | 2006 | 357 |
| Crystal structure of human cytochrome P450 2D6 | Journal of Biological Chemistry | 2006 | 351 |
| COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord | BMC Neurology | 2006 | 344 |
| Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules | British Journal of Pharmacology | 2006 | 320 |
| A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 308 |
| Large-conductance, calcium-activated potassium channels: structural and functional implications | | 2006 | 259 |
| Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents | Pediatrics | 2006 | 255 |
| Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells | Journal of Immunology | 2006 | 252 |
| Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine | Journal of Lipid Research | 2006 | 247 |
| Applications of fMRI in translational medicine and clinical practice | Nature Reviews Neuroscience | 2006 | 244 |
| In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates | Drug Metabolism and Disposition | 2006 | 235 |
| Role of macromolecular assembly of enamel matrix proteins in enamel formation | Journal of Dental Research | 2006 | 231 |
| Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 | Cancer Research | 2006 | 229 |
| Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care | BMJ, The | 2006 | 228 |
| The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity | Journal of Neuroscience | 2006 | 227 |
| Minimal clinically important change on the unified Parkinson's disease rating scale | Movement Disorders | 2006 | 218 |
| Evolution of multi-drug resistant hepatitis B virus during sequential therapy | Hepatology | 2006 | 210 |
| The American College of Rheumatology response criteria for proliferative and membranous renal disease in systemic lupus erythematosus clinical trials | Arthritis and Rheumatism | 2006 | 204 |
| Spirituality and religion in patients with HIV/AIDS | Journal of General Internal Medicine | 2006 | 204 |
| GABA and glycine as neurotransmitters: a brief history | British Journal of Pharmacology | 2006 | 203 |
| Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations | Pain | 2006 | 202 |
| Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration study | Arthritis and Rheumatism | 2006 | 200 |
