| # | Title | Journal | Year | Citations |
|---|
| 1 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1 | Advanced Drug Delivery Reviews | 2001 | 11,703 |
| 2 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings | Advanced Drug Delivery Reviews | 1997 | 8,880 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage | Nature | 2000 | 3,895 |
| 5 | Crizotinib versus Chemotherapy in AdvancedALK-Positive Lung Cancer | New England Journal of Medicine | 2013 | 3,181 |
| 6 | An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Nature | 2005 | 3,157 |
| 7 | First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer | New England Journal of Medicine | 2014 | 2,808 |
| 8 | Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction | International Journal of Impotence Research | 1999 | 2,460 |
| 9 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial | Lancet, The | 2011 | 1,663 |
| 10 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals | Regulatory Toxicology and Pharmacology | 2000 | 1,602 |
| 11 | The Future of Peptide‐based Drugs | Chemical Biology and Drug Design | 2013 | 1,483 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 13 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings | Advanced Drug Delivery Reviews | 2012 | 1,407 |
| 14 | Anidulafungin versus Fluconazole for Invasive Candidiasis | New England Journal of Medicine | 2007 | 1,344 |
| 15 | Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults | Nature | 2020 | 1,197 |
| 16 | What is the true solubility advantage for amorphous pharmaceuticals? | Nature | 2000 | 1,186 |
| 17 | Sexual problems among women and men aged 40–80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors | International Journal of Impotence Research | 2005 | 1,167 |
| 18 | PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro | Breast Cancer Research | 2009 | 1,131 |
| 19 | The prevalence of pituitary adenomas | Cancer | 2004 | 1,126 |
| 20 | Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? | Environmental Health Perspectives | 2012 | 1,033 |
| 21 | Estimates of Current and Future Incidence and Prevalence of Atrial Fibrillation in the U.S. Adult Population | American Journal of Cardiology | 2013 | 1,032 |
| 22 | Current and Emerging Azole Antifungal Agents | Clinical Microbiology Reviews | 1999 | 960 |
| 23 | HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin | Nature Genetics | 2009 | 950 |
| 24 | Diagnostic evaluation of the erectile function domain of the international index of erectile function | Urology | 1999 | 921 |
| 25 | A potent nonpeptide antagonist of the substance P (NK1) receptor | Science | 1991 | 888 |
| 26 | The International Index of Erectile Function (IIEF): a state-of-the-science review | International Journal of Impotence Research | 2002 | 871 |
| 27 | Clinical Trials in Head Injury | Journal of Neurotrauma | 2002 | 868 |
| 28 | In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth | Journal of Neurotrauma | 1997 | 856 |
| 29 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis | Lancet Oncology, The | 2011 | 847 |
| 30 | Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. | Journal of Clinical Investigation | 1996 | 833 |
| 31 | Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review | Cancer Treatment Reviews | 2008 | 832 |
| 32 | Altered Cytokine Production in Mice Lacking P2X7Receptors | Journal of Biological Chemistry | 2001 | 830 |
| 33 | Interpreting Indirect Treatment Comparisons and Network Meta-Analysis for Health-Care Decision Making: Report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: Part 1 | Value in Health | 2011 | 822 |
| 34 | Prevalence of the metabolic syndrome and overweight among adults in China | Lancet, The | 2005 | 813 |
| 35 | Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta | Science | 1989 | 795 |
| 36 | Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction | BJU International | 2011 | 790 |
| 37 | Pharmaco-metabonomic phenotyping and personalized drug treatment | Nature | 2006 | 787 |
| 38 | Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3 | Journal of Experimental Medicine | 1998 | 784 |
| 39 | Neuropsychiatric symptoms in Alzheimer's disease | Alzheimer's and Dementia | 2011 | 752 |
| 40 | Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer | Nature Communications | 2017 | 743 |
| 41 | Recombinant Protein Expression in Pichia pastoris | Molecular Biotechnology | 2000 | 732 |
| 42 | The pharmacokinetics of azithromycin in human serum and tissues | Journal of Antimicrobial Chemotherapy | 1990 | 724 |
| 43 | Cellular Cholesterol Efflux Mediated by Cyclodextrins | Journal of Biological Chemistry | 1995 | 723 |
| 44 | Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease | Health and Quality of Life Outcomes | 2004 | 722 |
| 45 | Core Outcome Domains and Measures for Pediatric Acute and Chronic/Recurrent Pain Clinical Trials: PedIMMPACT Recommendations | Journal of Pain | 2008 | 718 |
| 46 | Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals | Cell Metabolism | 2008 | 708 |
| 47 | The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well‐being in men and women: results from the EPIC study | BJU International | 2008 | 700 |
| 48 | Large-Scale Oxidations in the Pharmaceutical Industry | Chemical Reviews | 2006 | 682 |
| 49 | Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial | Journal of Clinical Oncology | 2013 | 678 |
| 50 | Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 665 |
