| # | Title | Journal | Year | Citations |
|---|
| 1 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling | Nature | 2000 | 8,977 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis | Lancet Infectious Diseases, The | 2018 | 3,672 |
| 4 | Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis | Lancet, The | 2014 | 3,224 |
| 5 | Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations | Journal of Pain | 2008 | 2,564 |
| 6 | The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements | Nature Biotechnology | 2006 | 1,927 |
| 7 | Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials | Lancet, The | 2010 | 1,871 |
| 8 | Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report | Journal of Allergy and Clinical Immunology | 2010 | 1,614 |
| 9 | Applications of nanotechnology in food packaging and food safety: Barrier materials, antimicrobials and sensors | Journal of Colloid and Interface Science | 2011 | 1,588 |
| 10 | Mechanisms of nanotoxicity: Generation of reactive oxygen species | Journal of Food and Drug Analysis | 2014 | 1,061 |
| 11 | A call for transparent reporting to optimize the predictive value of preclinical research | Nature | 2012 | 1,055 |
| 12 | EULAR recommendations for the management of primary small and medium vessel vasculitis | Annals of the Rheumatic Diseases | 2009 | 889 |
| 13 | Sarcopenia With Limited Mobility: An International Consensus | Journal of the American Medical Directors Association | 2011 | 884 |
| 14 | American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials | Arthritis and Rheumatism | 2011 | 864 |
| 15 | A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus | Nature Genetics | 2013 | 843 |
| 16 | Demyelination occurring during anti-tumor necrosis factor ? therapy for inflammatory arthritides | Arthritis and Rheumatism | 2001 | 813 |
| 17 | The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models | Nature Biotechnology | 2010 | 795 |
| 18 | A tetrahedral modeling method for electromagnetic scattering by arbitrarily shaped inhomogeneous dielectric bodies | IEEE Transactions on Antennas and Propagation | 1984 | 775 |
| 19 | Case Definition and Phenotype Standardization in Drug-Induced Liver Injury | Clinical Pharmacology and Therapeutics | 2011 | 773 |
| 20 | The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia | Blood | 2011 | 746 |
| 21 | Animal models for COVID-19 | Nature | 2020 | 705 |
| 22 | Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society | Journal of Clinical Endocrinology and Metabolism | 2000 | 703 |
| 23 | American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials | Annals of the Rheumatic Diseases | 2011 | 657 |
| 24 | Tumor necrosis factor antagonist therapy and lymphoma development: Twenty-six cases reported to the Food and Drug Administration | Arthritis and Rheumatism | 2002 | 655 |
| 25 | Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation | EMBO Journal | 2011 | 655 |
| 26 | Design and methods of the Population Assessment of Tobacco and Health (PATH) Study | Tobacco Control | 2017 | 642 |
| 27 | The BioPAX community standard for pathway data sharing | Nature Biotechnology | 2010 | 613 |
| 28 | Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers | Journal of the American Chemical Society | 2016 | 611 |
| 29 | Single-Cell RNA-Seq Technologies and Related Computational Data Analysis | Frontiers in Genetics | 2019 | 611 |
| 30 | e-Cigarette Use Among Youth in the United States, 2019 | JAMA - Journal of the American Medical Association | 2019 | 602 |
| 31 | EULAR recommendations for the management of large vessel vasculitis | Annals of the Rheumatic Diseases | 2009 | 596 |
| 32 | Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV | Journal of Virological Methods | 2004 | 591 |
| 33 | Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products | Journal of Immunological Methods | 2004 | 576 |
| 34 | Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency | Nature Immunology | 2014 | 575 |
| 35 | Velcade ® : U.S. FDA Approval for the Treatment of Multiple Myeloma Progressing on Prior Therapy | Oncologist | 2003 | 562 |
| 36 | Potential integrals for uniform and linear source distributions on polygonal and polyhedral domains | IEEE Transactions on Antennas and Propagation | 1984 | 560 |
| 37 | Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events | Nature Biotechnology | 2008 | 559 |
| 38 | Evaluation of DNA microarray results with quantitative gene expression platforms | Nature Biotechnology | 2006 | 558 |
| 39 | Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease | Blood | 2014 | 555 |
| 40 | Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies | Nature Biotechnology | 2010 | 552 |
| 41 | Tobacco-Product Use by Adults and Youths in the United States in 2013 and 2014 | New England Journal of Medicine | 2017 | 545 |
| 42 | Development and initial validation of an expanded and revised version of the Short-form McGill Pain Questionnaire (SF-MPQ-2) | Pain | 2009 | 539 |
| 43 | Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations | Pain | 2009 | 524 |
| 44 | Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 517 |
| 45 | Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys | Neurotoxicology and Teratology | 2011 | 516 |
| 46 | Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: A review | Gastroenterology | 1996 | 515 |
| 47 | Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols | JAMA - Journal of the American Medical Association | 2018 | 507 |
| 48 | Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality | Journal of Pharmaceutical Sciences | 2009 | 492 |
| 49 | Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration | BMJ: British Medical Journal | 2009 | 479 |
| 50 | United States Food and Drug Administration Drug Approval Summary | Clinical Cancer Research | 2004 | 474 |
