| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular portraits of human breast tumours | Nature | 2000 | 13,397 |
| 2 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,060 |
| 3 | The validity of the Hospital Anxiety and Depression Scale | Journal of Psychosomatic Research | 2002 | 7,759 |
| 4 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 5 | Periodontal Disease in Pregnancy I. Prevalence and Severity | Acta Odontologica Scandinavica | 1963 | 5,958 |
| 6 | Plešovice zircon — A new natural reference material for U–Pb and Hf isotopic microanalysis | Chemical Geology | 2008 | 3,858 |
| 7 | Axonal Transection in the Lesions of Multiple Sclerosis | New England Journal of Medicine | 1998 | 3,776 |
| 8 | A Non-Local Algorithm for Image Denoising | | 0 | 3,513 |
| 9 | Qualitative research: standards, challenges, and guidelines | Lancet, The | 2001 | 3,182 |
| 10 | Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest | New England Journal of Medicine | 2013 | 2,805 |
| 11 | Assembly, configuration, and break-up history of Rodinia: A synthesis | Precambrian Research | 2008 | 2,747 |
| 12 | ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) | European Heart Journal | 2008 | 2,656 |
| 13 | Microbial biogeography: putting microorganisms on the map | Nature Reviews Microbiology | 2006 | 2,434 |
| 14 | The accessible chromatin landscape of the human genome | Nature | 2012 | 2,434 |
| 15 | Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma | Clinical Cancer Research | 2004 | 2,393 |
| 16 | The Precision-Recall Plot Is More Informative than the ROC Plot When Evaluating Binary Classifiers on Imbalanced Datasets | PLoS ONE | 2015 | 2,354 |
| 17 | The New Institutionalism: Organizational Factors in Political Life | American Political Science Review | 1983 | 2,343 |
| 18 | A standard protocol for describing individual-based and agent-based models | Ecological Modelling | 2006 | 2,219 |
| 19 | Archaea predominate among ammonia-oxidizing prokaryotes in soils | Nature | 2006 | 2,144 |
| 20 | Whole genomes redefine the mutational landscape of pancreatic cancer | Nature | 2015 | 2,132 |
| 21 | Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study | European Urology | 2006 | 2,119 |
| 22 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 23 | The formalin test: an evaluation of the method | Pain | 1992 | 1,932 |
| 24 | Homocysteine and Cardiovascular Disease | Annual Review of Medicine | 1998 | 1,924 |
| 25 | The ODD protocol: A review and first update | Ecological Modelling | 2010 | 1,913 |
| 26 | Processing Fluency and Aesthetic Pleasure: Is Beauty in the Perceiver's Processing Experience? | Personality and Social Psychology Review | 2004 | 1,896 |
| 27 | ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008‡ | European Journal of Heart Failure | 2008 | 1,893 |
| 28 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 29 | Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome | New England Journal of Medicine | 2015 | 1,856 |
| 30 | International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study | Lancet, The | 2007 | 1,818 |
| 31 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,760 |
| 32 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial | Lancet, The | 2008 | 1,759 |
| 33 | The formalin test in mice: dissociation between inflammatory and non-inflammatory pain | Pain | 1987 | 1,731 |
| 34 | High-quality health systems in the Sustainable Development Goals era: time for a revolution | The Lancet Global Health | 2018 | 1,721 |
| 35 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 36 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,634 |
| 37 | Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency | New England Journal of Medicine | 2009 | 1,633 |
| 38 | Processes and patterns of oceanic nutrient limitation | Nature Geoscience | 2013 | 1,627 |
| 39 | Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease | New England Journal of Medicine | 1997 | 1,626 |
| 40 | Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis | New England Journal of Medicine | 2012 | 1,594 |
| 41 | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder | Nature Genetics | 2019 | 1,594 |
| 42 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 43 | A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules | Journal of Experimental Medicine | 2015 | 1,543 |
| 44 | AD Model Builder: using automatic differentiation for statistical inference of highly parameterized complex nonlinear models | Optimization Methods and Software | 2012 | 1,494 |
| 45 | Tunicates and not cephalochordates are the closest living relatives of vertebrates | Nature | 2006 | 1,488 |
| 46 | Microbial diversity and function in soil: from genes to ecosystems | Current Opinion in Microbiology | 2002 | 1,466 |
| 47 | Why invest, and what it will take to improve breastfeeding practices? | Lancet, The | 2016 | 1,455 |
| 48 | High abundance of viruses found in aquatic environments | Nature | 1989 | 1,448 |
| 49 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 50 | Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization | Science | 2007 | 1,423 |
