| # | Title | Journal | Year | Citations |
|---|
| 1 | A New Equation to Estimate Glomerular Filtration Rate | Annals of Internal Medicine | 2009 | 19,025 |
| 2 | Multilineage Potential of Adult Human Mesenchymal Stem Cells | Science | 1999 | 18,830 |
| 3 | DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs | IEEE Transactions on Pattern Analysis and Machine Intelligence | 2018 | 11,963 |
| 4 | Bioconductor: open software development for computational biology and bioinformatics | Genome Biology | 2004 | 10,796 |
| 5 | Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2015 | 10,755 |
| 6 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data | Biostatistics | 2003 | 9,603 |
| 7 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 8 | A model of saliency-based visual attention for rapid scene analysis | IEEE Transactions on Pattern Analysis and Machine Intelligence | 1998 | 9,026 |
| 9 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling | Nature | 2000 | 8,977 |
| 10 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads | Nature Biotechnology | 2015 | 8,385 |
| 11 | An interactive web-based dashboard to track COVID-19 in real time | Lancet Infectious Diseases, The | 2020 | 8,302 |
| 12 | The Sloan Digital Sky Survey: Technical Summary | Astronomical Journal | 2000 | 8,099 |
| 13 | The Clavien-Dindo Classification of Surgical Complications | Annals of Surgery | 2009 | 8,080 |
| 14 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,696 |
| 15 | Human papillomavirus is a necessary cause of invasive cervical cancer worldwide | New England Journal of Medicine | 1999 | 7,095 |
| 16 | The Compressibility of Media under Extreme Pressures | Proceedings of the National Academy of Sciences of the United States of America | 1944 | 7,006 |
| 17 | Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer | New England Journal of Medicine | 2012 | 6,820 |
| 18 | Intensities of Crystal Spectra of Rare‐Earth Ions | Journal of Chemical Physics | 1962 | 6,660 |
| 19 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype | Nature Biotechnology | 2019 | 6,567 |
| 20 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 21 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors | Advances in Enzyme Regulation | 1984 | 6,213 |
| 22 | Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2009 | 6,039 |
| 23 | Maternal and child undernutrition and overweight in low-income and middle-income countries | Lancet, The | 2013 | 5,719 |
| 24 | Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee | Arthritis and Rheumatism | 1986 | 5,701 |
| 25 | Whole-genome random sequencing and assembly of Haemophilus influenzae Rd | Science | 1995 | 5,619 |
| 26 | Why Don't Physicians Follow Clinical Practice Guidelines? | JAMA - Journal of the American Medical Association | 1999 | 5,548 |
| 27 | Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2006 | 5,525 |
| 28 | Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer | New England Journal of Medicine | 2010 | 5,481 |
| 29 | Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems | Lancet, The | 2019 | 5,421 |
| 30 | IDH1andIDH2Mutations in Gliomas | New England Journal of Medicine | 2009 | 5,285 |
| 31 | Three‐Year Wilkinson Microwave Anisotropy Probe ( WMAP ) Observations: Implications for Cosmology | Astrophysical Journal, Supplement Series | 2007 | 5,244 |
| 32 | Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure | New England Journal of Medicine | 2004 | 5,193 |
| 33 | A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure | New England Journal of Medicine | 1997 | 4,957 |
| 34 | Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer | New England Journal of Medicine | 2005 | 4,956 |
| 35 | The fundamental role of epigenetic events in cancer | Nature Reviews Genetics | 2002 | 4,872 |
| 36 | affy--analysis of Affymetrix GeneChip data at the probe level | Bioinformatics | 2004 | 4,830 |
| 37 | Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown | Nature Protocols | 2016 | 4,743 |
| 38 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 39 | Dementia prevention, intervention, and care: 2020 report of the Lancet Commission | Lancet, The | 2020 | 4,658 |
| 40 | Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities | Human Heredity | 2013 | 4,646 |
| 41 | Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions | The Cochrane Library | 2019 | 4,644 |
| 42 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 43 | Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival | Nature Medicine | 2004 | 4,442 |
| 44 | Summaries of Affymetrix GeneChip probe level data | Nucleic Acids Research | 2003 | 4,372 |
| 45 | An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU | New England Journal of Medicine | 2006 | 4,369 |
| 46 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 47 | Dementia prevention, intervention, and care | Lancet, The | 2017 | 4,228 |
| 48 | Prevalence of Chronic Kidney Disease in the United States | JAMA - Journal of the American Medical Association | 2007 | 4,121 |
| 49 | Current Concepts in Mild Cognitive Impairment | Archives of Neurology | 2001 | 4,117 |
| 50 | FIVE-YEARWILKINSON MICROWAVE ANISOTROPY PROBEOBSERVATIONS: COSMOLOGICAL INTERPRETATION | Astrophysical Journal, Supplement Series | 2009 | 4,114 |
