| # | Title | Journal | Year | Citations |
|---|
| 1 | Virological assessment of hospitalized patients with COVID-2019 | Nature | 2020 | 5,822 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 4 | Pathobiology of ischaemic stroke: an integrated view | Trends in Neurosciences | 1999 | 3,484 |
| 5 | Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany | New England Journal of Medicine | 2020 | 3,343 |
| 6 | MutationTaster2: mutation prediction for the deep-sequencing age | Nature Methods | 2014 | 3,203 |
| 7 | Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis | New England Journal of Medicine | 2002 | 3,048 |
| 8 | 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2010 | 2,994 |
| 9 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 10 | Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors | Science | 2020 | 2,527 |
| 11 | Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution | Nature | 2001 | 2,388 |
| 12 | CADD: predicting the deleteriousness of variants throughout the human genome | Nucleic Acids Research | 2019 | 2,360 |
| 13 | The single-cell transcriptional landscape of mammalian organogenesis | Nature | 2019 | 2,292 |
| 14 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper | Journal of the American College of Cardiology | 2009 | 2,055 |
| 15 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 16 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 17 | Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis | Lancet Respiratory Medicine,the | 2019 | 1,866 |
| 18 | Biodegradable metals | Materials Science and Engineering Reports | 2014 | 1,816 |
| 19 | Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions | Cell | 2015 | 1,725 |
| 20 | Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation | New England Journal of Medicine | 2009 | 1,655 |
| 21 | Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency | New England Journal of Medicine | 2009 | 1,633 |
| 22 | Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions | Nature Neuroscience | 2019 | 1,589 |
| 23 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 24 | Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer | PLoS ONE | 2013 | 1,502 |
| 25 | Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial | Lancet, The | 2019 | 1,494 |
| 26 | Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction | New England Journal of Medicine | 2019 | 1,485 |
| 27 | Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis | New England Journal of Medicine | 2016 | 1,467 |
| 28 | Rheumatoid arthritis | Nature Reviews Disease Primers | 2018 | 1,441 |
| 29 | Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer | Journal of Clinical Oncology | 2010 | 1,438 |
| 30 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs | Annals of the Rheumatic Diseases | 2010 | 1,429 |
| 31 | 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy | European Heart Journal | 2018 | 1,396 |
| 32 | Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy | Lancet Oncology, The | 2018 | 1,327 |
| 33 | The Assessment of SpondyloArthritis international Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general | Annals of the Rheumatic Diseases | 2011 | 1,302 |
| 34 | Unconscious determinants of free decisions in the human brain | Nature Neuroscience | 2008 | 1,297 |
| 35 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 | JAMA Oncology | 2018 | 1,260 |
| 36 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,230 |
| 37 | Genome-wide association study identifies 74 loci associated with educational attainment | Nature | 2016 | 1,204 |
| 38 | Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment | Cell | 2020 | 1,162 |
| 39 | Walking the Interactome for Prioritization of Candidate Disease Genes | American Journal of Human Genetics | 2008 | 1,111 |
| 40 | Oncogene-induced senescence as an initial barrier in lymphoma development | Nature | 2005 | 1,089 |
| 41 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 42 | Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease | Nature Reviews Neuroscience | 2014 | 1,069 |
| 43 | TFOS DEWS II pathophysiology report | Ocular Surface | 2017 | 1,049 |
| 44 | Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A | Environmental Health Perspectives | 2010 | 1,038 |
| 45 | Crystal structure of opsin in its G-protein-interacting conformation | Nature | 2008 | 1,019 |
| 46 | Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death | Cell Metabolism | 2008 | 1,009 |
| 47 | Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 | Nature Medicine | 2002 | 1,008 |
| 48 | In vivo effects of bisphenol A in laboratory rodent studies | Reproductive Toxicology | 2007 | 1,000 |
| 49 | Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 | Nature Neuroscience | 2021 | 991 |
| 50 | Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization | PLoS ONE | 2012 | 983 |
